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Centromere protein J is overexpressed in human glioblastoma and promotes cell proliferation and migration
AbstractGlioblastoma is the most common and malignant type of primary brain tumor. Previous studies have shown that alterations in centrosome amplification and its components are frequently found in treatment-resistant tumors and may be associated with tumor progression. A centrosome protein essential for centrosome biogenesis is the centromere protein J (CENPJ), known to control the proliferation of neural progenitors and hepatocarcinoma cells, and also neuronal migration. However, it remains unknown the role of CENPJ in glioblastoma. Here we show that CENPJ is overexpressed in human glioblastoma cell lines in comparison ...
Source: Journal of Neurochemistry - July 7, 2022 Category: Neuroscience Authors: Gabriella P. A. de Freitas, Luiz Henrique M. Geraldo, Bruna M. Faria, Soniza Vieira Alves ‐Leon, Jorge Marcondes de Souza, Vivaldo Moura‐Neto, Bruno Pontes, Luciana F. Romão, Patrícia P. Garcez Tags: ORIGINAL ARTICLE Source Type: research

Regulation of temozolomide resistance in glioma cells via the RIP2/NF- κB/MGMT pathway.
CONCLUSION: We report that the RIP2/NF-κB/MGMT signaling pathway is involved in the regulation of TMZ resistance. Interference with NF-κB or MGMT activity could constitute a novel strategy for the treatment of RIP2-positive TMZ-resistant glioma. PMID: 33460245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 18, 2021 Category: Neuroscience Authors: Hu YH, Jiao BH, Wang CY, Wu JL Tags: CNS Neurosci Ther Source Type: research

Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migration and Invasion and the Implications for the Regulation of Tumorigenesis
AbstractMinichromosome maintenance 10 (MCM10) plays an important role in DNA replication and is expressed in a variety of tumors, including glioma. However, its role and mechanism in glioma remain elusive. The purpose of this study was to examine the molecular function of MCM10 in glioblastoma cell lines in vitro and to further investigate the molecular mechanisms in the network mediated by MCM10. Cell proliferation, invasion, and migration were investigated in the absence of MCM10 mediated by RNA interference (RNAi) in U87 and U251 cell lines. Microarray data were obtained from U87 cells infected with a lentivirus express...
Source: Journal of Molecular Neuroscience - February 5, 2020 Category: Neuroscience Source Type: research

microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3.
CONCLUSION: Taken together, the miR cluster MC-let-7a-1 ~ let-7d promotes glioma cell autophagy and apoptosis by repressing STAT3. The current study highlights the potential of the miR cluster MC-let-7a-1 ~ let-7d as biomarkers and promising treatment strategies for glioma. PMID: 31868319 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 22, 2019 Category: Neuroscience Authors: Yang ZY, Wang Y, Liu Q, Wu M Tags: CNS Neurosci Ther Source Type: research

TGF ‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities
AbstractFollowing peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and remodel the extracellular matrix allowing axonal regrowth. Although much evidence has demonstrated that TGF ‐β1 promotes glioma cell motility and induces the expression of extracellular matrix proteins, the effects of TGF‐β1 on Schwann cell migration has not yet been studied. We therefore investigated the cellular effects and the signal transduction pathways evoked by TGF‐β1 inrattus norvegicus neuronal Schwann RSC96 cell. TGF ‐β1 significantly increased migration and invasion of Schwann cells assessed by wound‐he...
Source: Journal of Neurochemistry - November 14, 2019 Category: Neuroscience Authors: Antonella Muscella, Carla Vetrugno, Luca Giulio Cossa, Santo Marsigliante Tags: Original Article Source Type: research

LncRNA FOXD1-AS1 acts as a potential oncogenic biomarker in glioma.
CONCLUSIONS: These data indicated that FOXD1-AS1, a miR339/342 target, affected biological processes via protein eIF5a; thus, it might be considered as a new therapeutic target for glioblastoma. PMID: 31102349 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 16, 2019 Category: Neuroscience Authors: Gao YF, Liu JY, Mao XY, He ZW, Zhu T, Wang ZB, Li X, Yin JY, Zhang W, Zhou HH, Liu ZQ Tags: CNS Neurosci Ther Source Type: research

Downregulation of AIF-2 Inhibits Proliferation, Migration, and Invasion of Human Glioma Cells via Mitochondrial Dysfunction
In conclusion, we found that AIF-2 plays a key role in promoting cell proliferation, invasion, and migration via regulating AIF-1-related mitochondrial cascades. Downregulation of the candidate oncogene AIF-2 might constitute a strategy to kill human glioma cells.
Source: Journal of Molecular Neuroscience - April 12, 2019 Category: Neuroscience Source Type: research

MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway.
CONCLUSION: MicroRNA-21 might promote cell proliferation and inhibit cell senescence and apoptosis of human glioma cells by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. PMID: 29316313 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 5, 2018 Category: Neuroscience Authors: Chai C, Song LJ, Han SY, Li XQ, Li M Tags: CNS Neurosci Ther Source Type: research

Effect of pannexin-1 on the release of glutamate and cytokines in astrocytes
Publication date: Available online 16 September 2015 Source:Journal of Clinical Neuroscience Author(s): Li Wei, Hanmiao Sheng, Long Chen, Bin Hao, Xiaohong Shi, Yinghui Chen We investigated the effect of pannexin-1 (PANX-1) on the release of glutamate and cytokines in U87 human malignant glioma (U87-MG) cells using small interfering RNA (siRNA) transfection and adenosine triphosphate/lipopolysaccharide treatment. PANX-1 is a new family member of the gap junction proteins, and is permeable to ions, metabolic molecules, second messengers, and neurotransmitters, among other factors. PANX-1 plays an important role in t...
Source: Journal of Clinical Neuroscience - September 18, 2015 Category: Neuroscience Source Type: research

The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells
Publication date: Available online 26 July 2015 Source:Neurochemistry International Author(s): Xin Yang, Qiu-Feng Dong, Li-Wen Li, Jun-Li Huo, Peng-Qi Li, Zhou Fei, Hai-Ning Zhen Translation initiation factors (eIFs) are over-activated in many human cancers and may contribute to their progression. The small molecule 4EGI-1, a potent inhibitor of translation initiation through disrupting eIF4E/eIF4G interaction, has been shown to exert anti-cancer effects in human cancer cells. The goal of the present study was to evaluate the anti-cancer effects of 4EGI-1 in human glioma U251 cells. We found that 4EGI-1 impaired t...
Source: Neurochemistry International - July 27, 2015 Category: Neuroscience Source Type: research

Cytoprotection against beta-amyloid (Aβ) peptide-mediated oxidative damage and autophagy by Keap1 RNAi in human glioma U87mg cells
Publication date: Available online 20 January 2015 Source:Neuroscience Research Author(s): Pilju Youn , Yizhe Chen , Darin Y. Furgeson Extensive oxidative stress has been considered a primary pathological factor for many neurodegenerative disorders (NDDs). We speculated that the oxidative damage to brain cells can be managed by promoting the endogenous cellular antioxidants through the RNA interference (RNAi) against Keap1 (kelch-like ECH-associated protein). Keap1 acts as a negative regulator of Nrf2 (NF-E2-related factor 2) that represses the activation of the antioxidant responsive element (ARE). Here, we investigated...
Source: Neuroscience Research - January 30, 2015 Category: Neuroscience Source Type: research

FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/β-catenin Complex Formation
In this study, we found that FRK over-expression increased the protein level of N-cadherin, but not E-cadherin. Meanwhile, FRK over-expression promoted β-catenin translocation to the plasma membrane, where it formed complex with N-cadherin, while decreased β-catenin level in the nuclear fraction. In addition, down-regulation of N-cadherin by siRNA promoted the migration and invasion of glioma U251 and U87 cells and abolished the inhibitory effect of FRK on glioma cell migration and invasion. In summary, these results indicate that FRK inhibits migration and invasion of human glioma cells by promoting N-cadherin/β-catenin complex formation.
Source: Journal of Molecular Neuroscience - January 1, 2015 Category: Neuroscience Source Type: research

Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells.
CONCLUSION: We demonstrate that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells. TRPM7 channel may represent a novel and promising target for therapeutic intervention of malignant glioma. PMID: 25438992 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 1, 2014 Category: Neuroscience Authors: Leng TD, Li MH, Shen JF, Liu ML, Li XB, Sun HW, Branigan D, Zeng Z, Si HF, Li J, Chen J, Xiong ZG Tags: CNS Neurosci Ther Source Type: research

miR‐193b promotes cell proliferation by targeting Smad3 in human glioma
In conclusion, these results suggest that miR‐193b regulated cell growth in glioma through the TGF‐β pathway by regulating Smad3. Thus, our study indicates that miR‐193b promotes cell proliferation by targeting Smad3 in human glioma, which may serve as a potentially useful target for development of miRNA‐based therapies in the future. © 2014 Wiley Periodicals, Inc.
Source: Journal of Neuroscience Research - February 5, 2014 Category: Neuroscience Authors: Qisheng Zhong, Tongli Wang, Peigang Lu, Rongwei Zhang, Jianan Zou, Shaoji Yuan Tags: Research Article Source Type: research