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Cancer: Squamous Cell Carcinoma
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Total 783 results found since Jan 2013.
CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells
J Cell Mol Med. 2023 Apr 21. doi: 10.1111/jcmm.17750. Online ahead of print.ABSTRACTHuman oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased ...
Source: J Cell Mol Med - April 21, 2023 Category: Molecular Biology Authors: Chia-Yu Wu Pei-Wen Peng Ting-Yi Renn Chia-Jung Lee Tsung-Ming Chang Augusta I-Chin Wei Ju-Fang Liu Source Type: research
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway
Conclusion: The findings of this study reveal that Carbon ion knockdown was shown to downregulate LIF in ESCC cells. LIF is involved in ESCC proliferation and inhibited the ESCC cell proliferation by activating the STAT3 signaling pathways.PMID:37057285 | PMC:PMC10088534 | DOI:10.7150/jca.81222
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Hongtao Luo Zhen Yang Qiuning Zhang Tingdong Li Ruifeng Liu Shuangwu Feng Zhiqiang Liu Shilong Sun Junru Chen Xiaohu Wang Xiaoling Xie Source Type: research
CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
CONCLUSION: CCT6A facilitates ESCC malignant activities by activating the TGF-β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.PMID:37017854 | DOI:10.1007/s11845-023-03357-y
Source: Cancer Control - April 5, 2023 Category: Cancer & Oncology Authors: Xiuli Xia Shushan Zhao Wenting Chen Chao Xu Dongqiang Zhao Source Type: research
Cancers, Vol. 15, Pages 2005: CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Conclusion: Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.
Source: Cancers - March 28, 2023 Category: Cancer & Oncology Authors: Nitisha Shrivastava Claudia Gutierrez Chavez Daniel Li Vikas Mehta Carlos Thomas Cory D. Fulcher Nicole Kawachi Danielle M. Bottalico Michael B. Prystowsky Indranil Basu Chandan Guha Thomas J. Ow Tags: Article Source Type: research
BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway
Int J Oncol. 2023 Apr;62(4):54. doi: 10.3892/ijo.2023.5502. Epub 2023 Mar 17.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the main types of head and neck squamous cell carcinoma. Although progress has been made in treating OSCC, it remains a threat to human health, and novel therapeutic strategies are needed to extend the lifespan of patients with OSCC. The present study, evaluated whether bone marrow stromal antigen 2 (BST2) and STAT1 were potential therapeutic targets in OSCC. Small interfering RNA (siRNA) or overexpression plasmids were used to regulate BST2 or STAT1 expression. Western blotting and reverse tra...
Source: International Journal of Oncology - March 17, 2023 Category: Cancer & Oncology Authors: Fayu Shan Si Shen Xinxing Wang Gang Chen Source Type: research
GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
CONCLUSIONS: This research indicated that targeting LCN2 could be a promising strategy for the treatment of OSCC.PMID:36899380 | DOI:10.1186/s13046-023-02618-z
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Zixian Huang Xi Rui Chen Yi Yongju Chen Rui Chen Yancan Liang Yan Wang Weicheng Yao Xiaoding Xu Zhiquan Huang Source Type: research
Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma
AbstractEukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed in many cancers and affects their occurrence and development. However, the effect of EIF4G1 on the prognosis, biological function and the relevant mechanism in lung squamous cell carcinoma (LSCC) is unclear. Through clinical cases, Cox ’s proportional hazard model and Kaplan–Meier plotter survival analysis, we find the expression levels of EIF4G1 are dependent on age and clinical stage, high expression of EIF4G1 could be used to predict the overall survival of LSCC patients. LSCC cell line NCI-H1703, NCI-H226 and SK-MES-1infec ted w...
Source: Human Cell - March 10, 2023 Category: Cytology Source Type: research
