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Cancer: Squamous Cell Carcinoma

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Total 783 results found since Jan 2013.

Transgelin Inhibits the Malignant Progression of Esophageal Squamous Cell Carcinomas by Regulating Epithelial –Mesenchymal Transition
ConclusionTransgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT.
Source: Frontiers in Oncology - September 6, 2021 Category: Cancer & Oncology Source Type: research

LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells
Aging (Albany NY). 2021 Aug 30;13(undefined). doi: 10.18632/aging.203416. Online ahead of print.ABSTRACTTo explore the effects of lncRNA GACAT1/miR-149 molecular axis on the proliferation, apoptosis, migration and autophagy of oral squamous cell carcinoma (OSCC) cells, and to explore its molecular mechanism. The expressions of lncRNA GACAT1 and miR-149 in tissues and cell lines of patients with OSCC were detected by qRT-PCR. Si-control, GACAT1-siRNA, inhibitor NC and miR-149 inhibitors were transfected into OSCC cells separately or in combination with Lipofectamine 2000. The binding sites between lncRNA GACAT1 and miR-149 ...
Source: Aging - August 30, 2021 Category: Biomedical Science Authors: Jingxin Chen Xubin Chen Liangbin Fu Jimin Chen Yang Chen Feng Liu Source Type: research

Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
In this study, we performed a comprehensive transcriptome-based computational analysis on hundreds of HNSCC patients from TCGA and GEO databases, and found that DCLK1 expression positively correlates with NOTCH signaling pathway activation. Since NOTCH signaling has a recognized role in HNSCC tumorigenesis, we next performed a series of in vitro experiments in a collection of HNSCC cell lines to investigate the role of DCLK1 in NOTCH pathway regulation. Our analyses revealed that DCLK1 inhibition, using either a pharmacological inhibitor or siRNA, resulted in substantially decreased proliferation, invasion, migration, and ...
Source: Frontiers in Oncology - July 16, 2021 Category: Cancer & Oncology Source Type: research

FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation
CONCLUSION: FosL1 plays a crucial role in promoting cell migration, invasion, and proliferation in HNSCC.PMID:34230127 | DOI:10.21873/anticanres.15119
Source: Cell Research - July 7, 2021 Category: Cytology Authors: Hiroshi Hyakusoku Kae Sawakuma Daisuke Sano Hideaki Takahashi Takashi Hatano Kaname Sato Yasuhiro Isono Shoko Shimada Kentaro Takada Tatsu Kuwahara Yoshihiro Aizawa Nobuhiko Oridate Source Type: research

USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation
Ionizing radiation (IR) principally acts through induction of DNA damage that promotes cell death, although the biological effects of IR are more broad ranging. In fact, the impact of IR of higher-linear energy transfer (LET) on cell biology is generally not well understood. Critically, therefore, the cellular enzymes and mechanisms responsible for enhancing cell survival following high-LET IR are unclear. To this effect, we have recently performed siRNA screening to identify deubiquitylating enzymes that control cell survival specifically in response to high-LET α-particles and protons, in comparison to low-LET X-rays an...
Source: Frontiers in Oncology - July 1, 2021 Category: Cancer & Oncology Source Type: research

Trichostatin A promotes esophageal squamous cell carcinoma cell migration and EMT through BRD4/ERK1/2 ‐dependent pathway
ConclusionsOur data indicate the existence of at least two separable ERK1/2-dependent signaling pathways in TSA-mediated ESCC cell migration: an ERK1/2 –Slug branch and an ERK1/2-PAI-1 branch. Both branches of TSA-induced ESCC cell migration appear to favor the EMT process, while BRD4 is responsible for two separable ERK1/2-dependent signaling pathways in TSA-mediated ESCC cell migration.
Source: Cancer Medicine - June 23, 2021 Category: Cancer & Oncology Authors: Danhui Liu, Yuzhen Liu, Bo Qi, Chengwei Gu, Shuhua Huo, Baosheng Zhao Tags: ORIGINAL RESEARCH Source Type: research

GSE178669 Next Generation Sequencing Facilitates Quantitative Analysis of Control siRNA, RAB11A siRNA1 and RAB11A siRNA2 suppressed EBC-1 cell's Transcriptomes
This study aims to find cellular pathway changes in RAB11A suppressed in lung squamous cell carcinoma cell line EBC-1 compared to control and to evaluate downregulating genes by RAB11A suppression by siRNA. Total RNA was extracted from EBC-1 transfected with control siRNA and RAB11A specific siRNAs using the RNeasy mini kit (Qiagen, Hilden, Germany). CAGE library preparation, sequencing, mapping, and gene expression and motif discovery analysis were performed by DNAFORM (Yokohama, Japan). In brief, RNA quality was assessed by Bioanalyzer (Agilent) to ensure that RIN (RNA integrity number) is over 7.0 and A260/280 and 260/2...
Source: GEO: Gene Expression Omnibus - June 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma
J Cell Mol Med. 2021 May 27. doi: 10.1111/jcmm.16652. Online ahead of print.ABSTRACTMounting data have shown that long non-coding RNAs (lncRNAs) widely participate in tumour initiation, development, progression and glycolysis in a variety of tumours. However, the clinical prognosis and molecular mechanisms of TMEM161B-AS1 in oesophageal squamous cell carcinoma (ESCC) remain still unknown. Here, TMEM161B-AS1 and HIF1AN were significantly lower in ESCC tissues than in normal samples, and their low expressions were both related to TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Functionally, TMEM161B-AS1...
Source: J Cell Mol Med - May 28, 2021 Category: Molecular Biology Authors: Zuxuan Shi Guanghui Li Zhen Li Junhao Liu Yu Tang Source Type: research

Downregulated hsa_circ_0036988 promotes proliferation and metastasis in oral squamous cell carcinoma
CONCLUSIONS: Our findings indicated that hsa_circ_0036988 may affect cell proliferation, migration and invasion by regulating EMT progress, which might provide a therapeutic strategy for the treatment of OSCC.PMID:33896837 | DOI:10.3233/CBM-210082
Source: Cancer Biomarkers : Section A of Disease Markers - April 26, 2021 Category: Cancer & Oncology Authors: Hanyu Zhang Biru Zhang Ying Zhang Min Qian Yuehong Shen Hongyu Yang Source Type: research