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CX3CL1 induces cell migration and invasion through ICAM-1 expression in oral squamous cell carcinoma cells
J Cell Mol Med. 2023 Apr 21. doi: 10.1111/jcmm.17750. Online ahead of print.ABSTRACTHuman oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis. C-X3-C motif chemokine ligand 1 (CX3CL1) has been involved in advanced migratory cells. Overexpressed CX3CL1 promotes several cellular responses related to cancer metastasis, including cell movement, migration and invasion in tumour cells. However, CX3CL1 controls the migration ability, and its molecular mechanism in OSCC remains unknown. The present study confirmed that CX3CL1 increased ...
Source: J Cell Mol Med - April 21, 2023 Category: Molecular Biology Authors: Chia-Yu Wu Pei-Wen Peng Ting-Yi Renn Chia-Jung Lee Tsung-Ming Chang Augusta I-Chin Wei Ju-Fang Liu Source Type: research

Clear cell squamous cell carcinoma of the tongue exhibits characteristics as an undifferentiated squamous cell carcinoma
Pathol Res Pract. 2022 Apr 26;235:153909. doi: 10.1016/j.prp.2022.153909. Online ahead of print.ABSTRACTClear cell squamous cell carcinoma (CCSCC), where cells show abundant clear cytoplasm, -is a variant of squamous cell carcinoma (SCC) and a rare entity in the oral cavity. The characteristics of CCSCC, especially in immunohistochemical features, remain unclear. We characterized a case of CCSCC arising from the oral mucosal epithelium of tongue, where the clear cell lesion accounted for a predominant portion of the tumor. This CCSCC, which was partially surrounded by conventional SCC, exhibited cellular atypia immunohisto...
Source: Pathology, Research and Practice - May 13, 2022 Category: Pathology Authors: Kana Hasegawa Shinsuke Fujii Kari J Kurppa Takashi Maehara Kazunari Oobu Seiji Nakamura Tamotsu Kiyoshima Source Type: research

HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC ‑3 cells.
HIKESHI silencing can enhance mild hyperthermia sensitivity in human oral squamous cell carcinoma HSC‑3 cells. Int J Mol Med. 2020 Apr 28;: Authors: Tabuchi Y, Maekawa K, Torigoe M, Furusawa Y, Hirano T, Minagawa S, Yunoki T, Hayashi A Abstract Hyperthermia (HT) is considered to be of value as a treatment modality in various cancers. However, the acquisition of thermotolerance in cancer cells due to the induction of heat shock proteins (HSPs) makes HT less effective. Recent findings have indicated that heat shock protein nuclear import factor hikeshi (HIKESHI), also referred to as C11orf73, acts as ...
Source: International Journal of Molecular Medicine - April 27, 2020 Category: Molecular Biology Authors: Tabuchi Y, Maekawa K, Torigoe M, Furusawa Y, Hirano T, Minagawa S, Yunoki T, Hayashi A Tags: Int J Mol Med Source Type: research

WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating β-Catenin/MMP9-Mediated Signaling
ConclusionsThe data in this paper indicated that WNT7A could be a potential oncogene in OSCC and identified a novel PI3K/AKT/WNT7A/β-catenin/MMP9 signaling for EGF-induced migration of OSCC cells.
Source: Frontiers in Pharmacology - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 1583: CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation
Jung Sang-Jin Lee The membrane glycoprotein CD200 binds to its receptor CD200R1 and induces tolerance, mainly in cells of the myeloid lineage; however, information regarding its role in solid tumors is limited. Here, we investigated whether CD200 expression, which is enriched mainly in high-grade head and neck squamous cell carcinoma (HNSCC), correlates with cancer progression, particularly the epithelial-to-mesenchymal transition (EMT). The forced overexpression of CD200 in the HNSCC cell line, UMSCC84, not only increased the expression of EMT-related genes, but also enhanced invasiveness. The cleaved cytoplasmic do...
Source: Cancers - October 16, 2019 Category: Cancer & Oncology Authors: Seung-Phil Shin A-RA Goh Hyeon-Gu Kang Seok-Jun Kim Jong-Kwang Kim Kyung-Tae Kim John H Lee Yong-Soo Bae Yuh-Seog Jung Sang-Jin Lee Tags: Article Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

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