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Cancer: Astrocytoma

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Total 44 results found since Jan 2013.

Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1
In conclusion, Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity.
Source: Tumor Biology - February 20, 2016 Category: Cancer & Oncology Source Type: research

Up-Regulation of microRNA-183 Promotes Cell Proliferation and Invasion in Glioma By Directly Targeting NEFL.
This study revealed that miR-183 promotes glioma cell proliferation by targeting NEFL, and also demonstrated that miR-183 could be a potential target for GBM treatment. PMID: 26879754 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - February 15, 2016 Category: Cytology Authors: Wang ZY, Xiong J, Zhang SS, Wang JJ, Gong ZJ, Dai MH Tags: Cell Mol Neurobiol Source Type: research

Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma
Conclusions: The upregulation of KIF14 in astrocytoma is associated with disease severity, and suppression of KIF14 inhibits cell proliferation and induces apoptosis through a mechanism involving the inactivation of AKT signaling, suggesting that KIF14 plays an important role in astrocytoma tumorigenesis and could be a promising molecular target for anticancer therapy.Cell Physiol Biochem 2015;37:1659-1670
Source: Cellular Physiology and Biochemistry - November 5, 2015 Category: Cytology Source Type: research

Abstract 66: CD99 functional analysis in glioblastoma by RNAseq
CD99 is a membrane protein expressed in a wide variety of normal tissues and implicated in several cellular physiologic processes, including haematopoietic cell differentiation, proliferation, diapedesis, cell-cell adhesion, migration, apoptosis induction, cellular architecture maintenance and transmembrane protein transport. Additionally, aberrant CD99 expression has been associated with numerous malignancies, including astrocytomas. Amongst astrocytomas of different malignant grades, glioblastoma (GBM) is the most aggressive and common of central nervous system tumors. Despite current multimodal therapies, including surg...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Oba-Shinjo, S. M., Cardoso, L. C., Silva, R. d., Lerario, A. M., Uno, M., Marie, S. S. K. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3047: Mitochondrial DNA copy variation and TFAM expression in astrocytoma
Mitochondrial dysfunction plays a role in determining the phenotype through bioenergetic depletion and increased production of ROS in several diseases, including cancer. We have previously demonstrated a relevant reduction of mitochondrial DNA (mtDNA) copy number in astrocytoma of different grades of malignancy, predominantly in grade IV-glioblastoma (GBM). We observed a stepwise increase of TFAM in parallel to the increase of malignancy, and TFAM expression was higher in GBM patients with overall survival longer than 24 months than less than 12 months. TFAM is codified in the nucleus and transported into mitochondria, whe...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Marie, S. K., Silva, R., Lerario, A., Uno, M., Oba-Shinjo, S. M. Tags: Molecular and Cellular Biology Source Type: research

miR-25 promotes glioblastoma cell proliferation and invasion by directly targeting NEFL.
In this study, we demonstrated that miR-25 was significantly up-regulated in astrocytoma tissues and glioblastoma cell lines. In vitro studies further demonstrated that overexpressed miR-25 was able to promote, while its antisense oligos inhibited cell proliferation and invasion in U251 cells. Moreover, we identified neurofilament light polypeptide (NEFL) as a novel target molecule of miR-25. Also of note was the fact that NEFL was down-regulated with increased levels of miR-25 expression in human astrocytoma clinical specimens. In addition, via the mTOR signaling pathway, NEFL-siRNA could significantly attenuate the inhib...
Source: Molecular and Cellular Biochemistry - July 26, 2015 Category: Biochemistry Authors: Peng G, Yuan X, Yuan J, Liu Q, Dai M, Shen C, Ma J, Liao Y, Jiang W Tags: Mol Cell Biochem Source Type: research

Down-regulation of 14-3-3β exerts anti-cancer effects through inducing ER stress in human glioma U87 cells: Involvement of CHOP-Wnt pathway.
Abstract We previously identified 14-3-3β as a tumor-specific isoform of 14-3-3 protein in astrocytoma, but its functional role in glioma cells and underlying mechanisms are poorly understood. In the present study, we investigated the effects of 14-3-3β inhibition in human glioma U87 cells using specific targeted small interfering RNA (siRNA). The results showed that 14-3-3β is highly expressed in U87 cells but not in normal astrocyte SVGp12 cells. Knockdown of 14-3-3β by Si-14-3-3β transfection significantly decreased the cell viability but increased the LDH release in a time-dependent fashion in U87 cells, ...
Source: Biochemical and Biophysical Research communications - May 14, 2015 Category: Biochemistry Authors: Cao L, Lei H, Chang MZ, Liu ZQ, Bie XH Tags: Biochem Biophys Res Commun Source Type: research

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors.
In this study, we employed two-dimensional fluorescence differential gel electrophoresis (2-D DIGE) and MALDI-TOF/TOF-MS/MS to identify 27 differentially expressed proteins, including the significantly upregulated neurofilament light polypeptide (NEFL), in glioblastoma cells in which miR-381 expression was inhibited. We identified NEFL as a novel target molecule of miR-381 and a tumor suppressor gene. In human astrocytoma clinical specimens, NEFL was downregulated with increased levels of miR-381 expression. Either suppressing miR-381 or enforcing NEFL expression dramatically sensitized glioblastoma cells to temozolomide (...
Source: Oncotarget - January 27, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The doppel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells.
In this study, we aimed to investigate in vitro the potential involvement of Dpl in the tumor cell migration: to this purpose, Dpl expression was reduced in the IPDDC-A2 astrocytoma-derived cell line, by means of antisense and siRNA approaches; migration rates were then evaluated by means of a scratch wound healing assay. As a result, the cellular migration was sensibly reduced after Dpl silencing. Following a complementary approach, in HeLa cells, showing very low endogenous Dpl expression, the protein expression was induced by transfection and stabilization of an eukaryotic expression vector containing the doppel gene co...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research

Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death
Publication date: Available online 21 November 2014 Source:FEBS Open Bio Author(s): Jayashree C. Jagtap , Parveen D , Reecha D. Shah , Aarti Desai , Dipali Bhosale , Ashish Chugh , Deepak Ranade , Swapnil Karnik , Bhushan Khedkar , Aaishwarya Mathur , Kumar Natesh , Goparaju Chandrika , Padma Shastry Glioblastoma multiforme (GBM) is the most malignant form of brain tumor and is associated with resistance to conventional therapy and poor patient survival. Prostate apoptosis response (Par)-4, a tumor suppressor, is expressed as both an intracellular and secretory/extracellular protein. Though secretory Par-4 induces apopto...
Source: FEBS Open Bio - November 22, 2014 Category: Molecular Biology Source Type: research

Abstract 4607: Stathmin is involved in the maternal embryonic leucine zipper kinase pathway and impacts in the outcome of glioblastoma
This study aim to analyze proteins and/or genes involved in the MELK pathway in the tumorigenesis of gliomas. MATERIAL AND METHODS: Analysis of the expression profile of a panel of protein relevant to the process of tumorigenesis that MELK is involved was performed by Proteomic analysis by two dimensional electrophoresis and mass spectrometry for human glioma cell line U87MG transfected with siRNA for the MELK compared to U87MG transfected with non-target control (NTC) cells. Analysis and validation of gene expression was performed by Quantitative real time PCR (qRT-PCR) using SYBR Green method in a series of 153 astrocyto...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Uno, M., Oba-Shinjo, S. M., Silva, R., Gimenez, M., Rosa, J. C., Marie, S. K. N. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 3945: Inhibition of MMP2 expression enhances the efficacy of radiation therapy for a murine astrocytoma
This study provides a new treatment option for treating invasive brain tumors. (This study was supported by NHRI-EX103-10132BI and NSC 102-2314-B-007-003-MY3 grants) Citation Format: Ching-Fang Yu, Ying-Chieh Yang, Ji-Hong Hong, Chi-Shiun Chiang. Inhibition of MMP2 expression enhances the efficacy of radiation therapy for a murine astrocytoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3945. doi:10.1158/1538-7445.AM2014-3945
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yu, C.-F., Yang, Y.-C., Hong, J.-H., Chiang, C.-S. Tags: Tumor Biology Source Type: research

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
CONCLUSIONS: These data are the first to link PID1 to cancer and suggest that PID1 may have a tumor inhibitory function in these pediatric and adult brain tumors. PMID: 24300787 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - December 3, 2013 Category: Cancer & Oncology Authors: Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol A, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S Tags: Clin Cancer Res Source Type: research

Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.
Abstract The aim of the present study was to investigate whether silencing of Hsp27 or Hsp72 expression in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells increase their sensitivity to programmed cell death induction upon temozolomide and /or quercetin treatment. Transfection with specific siRNA was performed for the Hsp gene silencing. As revealed by microscopic observation and flow cytometry, the inhibition of Hsp expression was correlated with severe apoptosis induction upon the drug treatment studied. No signs of autophagy were detected. This was correlated with a decreased mitochondrial ...
Source: Toxicology and Applied Pharmacology - October 11, 2013 Category: Toxicology Authors: Jakubowicz-Gil J, Langner E, Bądziul D, Wertel I, Rzeski W Tags: Toxicol Appl Pharmacol Source Type: research