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Cancer: Melanoma

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& lt;i & lt;FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation
Mol Biol (Mosk). 2021 Jul-Aug;55(4):667-675. doi: 10.31857/S0026898421030058.ABSTRACTMicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to ...
Source: Molekuliarnaia Biologiia - August 25, 2021 Category: Molecular Biology Authors: I Yu Dubovtseva M B Aksenenko E D Nikolaeva A S Averchuk A V Moshev A A Savchenko S V Markova T G Ruksha Source Type: research

Cancers, Vol. 14, Pages 4776: Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia
Conclusion: Our results suggest that CAXII and the Hh pathway are relevant in melanoma invasion and may be novel and promising therapeutical targets for melanoma clinical management.
Source: Cancers - September 29, 2022 Category: Cancer & Oncology Authors: Gaia Giuntini Federica Coppola Alessandro Falsini Irene Filippi Sara Monaci Antonella Naldini Fabio Carraro Tags: Article Source Type: research

Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy
The objective of this study was to discover novel nodal autoantibodies in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We screened for autoantibodies that bind to mouse sciatic nerves and dorsal root ganglia (DRG) using indirect immunofluorescence (IFA) assays with sera from 113 patients with CIDP seronegative for anti-neurofascin 155 and anticontactin-1 antibodies and 127 controls. Western blotting, IFA assays using HEK293T cells transfected with relevant antigen expression plasmids, and cell-based RNA interference assays were used to identify target antigens. Krox20 and Periaxin expression, both of ...
Source: Neurology Neuroimmunology and Neuroinflammation - January 11, 2023 Category: Neurology Authors: Zhang, X., Kira, J.-I., Ogata, H., Imamura, T., Mitsuishi, M., Fujii, T., Kobayashi, M., Kitagawa, K., Namihira, Y., Ohya, Y., Maimaitijiang, G., Yamasaki, R., Fukata, Y., Fukata, M., Isobe, N., Nakamura, Y. Tags: Research Article Source Type: research

SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
CONCLUSION: SOX10 has a role in the intrinsic immune suppressive mechanisms of melanoma through expression of PD-L1.PMID:36974807 | DOI:10.21873/anticanres.16296
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Kenta Sasaki Yoshihiko Hirohashi Kenji Murata Tomoyuki Minowa Munehide Nakatsugawa Aiko Murai Yuka Mizue Terufumi Kubo Takayuki Kanaseki Tomohide Tsukahara Sadahiro Iwabuchi Shinichi Hashimoto Hisashi Uhara Akemi Ishida-Yamamoto Toshihiko Torigoe Source Type: research

3-deazaneplanocin A, a histone methyltransferase inhibitor, improved the chemoresistance induced under hypoxia in melanoma cells
In conclusion, a histone methyltransferase EZH2 inhibitor, DZNep was capable of tackling acquired chemoresistance via the suppression of histone methylation induced under hypoxic tumor microenvironment.PMID:37542772 | DOI:10.1016/j.bbrc.2023.08.003
Source: Biochemical and Biophysical Research communications - August 5, 2023 Category: Biochemistry Authors: Mika Hosokawa Sekai Tetsumoto Mirano Yasui Yusuke Kono Ken-Ichi Ogawara Source Type: research