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Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia
CONCLUSIONS: Overall, the current findings demonstrate that EVI-1 overexpression converges on the regulation of miR-124 promoter methylation and activation of the RAS/ERK pathway in AML carcinogenesis, and suggest EVI-1 and/or miR-124 as therapeutic targets for this dismal disease.PMID:35835333 | DOI:10.1016/j.cellsig.2022.110402
Source: Cellular Signalling - July 14, 2022 Category: Cytology Authors: Wenjing Lang Xiaofeng Han Jiayi Cai Fangyuan Chen Lan Xu Hua Zhong Jihua Zhong Source Type: research

TANK-binding kinase 1 inhibitor GSK8612 enhances daunorubicin sensitivity in acute myeloid leukemia cells via the AKT-CDK2 pathway
CONCLUSION: TBK1 is a potential prognostic factor for AML, and its inhibition may improve the sensitivity of AML cells to daunorubicin. This regulatory effect is predicted to involve the TBK1-AKT-CDK2 pathway.PMID:35035703 | PMC:PMC8748083
Source: Cell Research - January 17, 2022 Category: Cytology Authors: Siyu Chen Ming Ni Tianzhen Hu Yangguang Gu Cheng Feng Chengyun Pan Siyu Zhang Shuangshuang Wen Naiqin Zhao Weili Wang Lihong Dai Jishi Wang Source Type: research

LINC00265/miR-4500 Axis Accelerates Acute Lymphoblastic Leukemia Progression by Enhancing STAT3 Signals
CONCLUSION: Mechanistically, LncRNA LINC00265 can competitively interact with miR-4500 and thereby up-regulates STAT3 signaling and enhances the malignancy of tumors.PMID:34737643 | PMC:PMC8560060 | DOI:10.2147/CMAR.S274590
Source: Cell Research - November 5, 2021 Category: Cytology Authors: Donglu Zhao Qi Xing Hang Song Yan Zhao Guiying Guo Source Type: research

Aberrant TRPM4 expression in MLL-rearranged acute myeloid leukemia and its blockade induces cell cycle arrest via AKT/GLI1/Cyclin D1 pathway.
In conclusion, TRPM4 is overexpressed in MLL-rearranged AML and blockade of TRPM4 may be an alternative therapeutic approach in AML patients with high TRPM4 expression. PMID: 32320859 [PubMed - as supplied by publisher]
Source: Cellular Signalling - April 18, 2020 Category: Cytology Authors: Wang F, Wu P, Gong S, Chen Y, Gao J, Wang S, Shen Q, Tao H, Hua F, Zhou Z, Zou Z, Ma T, Jia Y Tags: Cell Signal Source Type: research

Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells.
This study aimed to examine the effect of decitabine (DAC) on FLT3-ITD positive AML. In our study, we found that expression of FLT3 and its downstream targets was decreased in FLT3-ITD mutant cell lines treated with DAC. DAC treatment could increase the percentage of apoptotic cells and CD11b positive cells tested by flow cytometry and upregulate the expression of cleaved caspase3, cleaved PARP, C/EBPa and PU.1 detected by western blot. To explore the effect of increased expression of PU.1 on FLT3 protein, we transiently transfected MOLM13 and MV4-11 cells with siRNA against PU.1 and a siRNA control. In both FLT3-ITD posit...
Source: Cellular Signalling - August 30, 2019 Category: Cytology Authors: Hu X, Cai J, Zhu J, Lang W, Zhong J, Zhong H, Chen F Tags: Cell Signal Source Type: research

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome
Conclusions: To our knowledge, this report is the first to demonstrate that lncRNAKcnq1ot1 downregulation is responsible for QT interval prolongation induced by ATO at least partially by repressingKcnq1 expression. lncRNAKcnq1ot1 has important pathophysiological functions in the heart and could become a novel antiarrhythmic target.Cell Physiol Biochem 2018;45:192 –202
Source: Cellular Physiology and Biochemistry - January 16, 2018 Category: Cytology Source Type: research

Acute myotube protein synthesis regulation by IL-6-related cytokines
IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the involvement of the ...
Source: AJP: Cell Physiology - November 1, 2017 Category: Cytology Authors: Gao, S., Durstine, J. L., Koh, H.-J., Carver, W. E., Frizzell, N., Carson, J. A. Tags: RESEARCH ARTICLE Source Type: research

Acute myotube protein synthesis regulation by IL-6-related cytokines.
Abstract IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the i...
Source: Am J Physiol Cell Ph... - November 1, 2017 Category: Cytology Authors: Gao S, Durstine JL, Koh HJ, Carver WE, Frizzell N, Carson JA Tags: Am J Physiol Cell Physiol Source Type: research

LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen.
Authors: Liu W, Li T, Wang P, Liu W, Liu F, Mo X, Liu Z, Song Q, Lv P, Ruan G, Han W Abstract Leukocyte differentiation antigens (LDAs) play important roles in the immune system, by serving as surface markers and participating in multiple biological activities, such as recognizing pathogens, mediating membrane signals, interacting with other cells or systems, and regulating cell differentiation and activation. Data mining is a powerful tool used to identify novel LDAs from whole genome. LRRC25 (leucine rich repeat-containing 25) was predicted to have a role in the function of myeloid cells by a large-scale "omics" ...
Source: Protein and Cell - May 26, 2017 Category: Cytology Tags: Protein Cell Source Type: research

Targeting AMPK-ULK1-mediated autophagy for combating BET inhibitor resistance in acute myeloid leukemia stem cells.
In this study, we evaluated the mechanisms underlying LSC resistance to the BET inhibitor JQ1. We evaluated the levels of apoptosis and macroautophagy/autophagy induced by JQ1 in LSC-like leukemia cell lines and primary CD34(+) CD38(-) leukemic blasts obtained from AML cases with normal karyotype without recurrent mutations. JQ1 effectively induced apoptosis in a concentration-dependent manner in JQ1-sensitive AML cells. However, in JQ1-resistant AML LSCs, JQ1 induced little apoptosis and led to upregulation of BECN1/beclin-1, increased LC3 lipidation, formation of autophagosomes, and downregulation of SQSTM1/p62. Inhibiti...
Source: Autophagy - January 23, 2017 Category: Cytology Authors: Jang JE, Eom JI, Jeung HK, Cheong JW, Lee JY, Kim JS, Min YH Tags: Autophagy Source Type: research

Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts
Conclusion: These data suggest that PML sumoylation is required for ATO-induced collagen synthesis in osteoblasts.Cell Physiol Biochem 2015;37:1581-1591
Source: Cellular Physiology and Biochemistry - October 31, 2015 Category: Cytology Source Type: research

The Association between p38 MAPK‐Mediated TNF‐α/TNFR2 Up‐Regulation and 2‐(4‐Aminophenyl)‐7‐Methoxybenzothiazole‐Induced Apoptosis in Human Leukemia U937 Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - June 8, 2015 Category: Cytology Authors: Chia‐Hui Huang, Ying‐Jung Chen, Tzu‐Yu Chao, Wen‐Hsin Liu, Jung‐Jung Changchien, Wan‐Ping Hu, Long‐Sen Chang Tags: Original Research Article Source Type: research

ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells
This study was performed using established cell lines HL60 and U937, and primary cultures of blasts from 10 patients with ML. We found that ERK5 and its direct downstream target transcription factor MEF2C are upregulated by 1,25D in parallel with monocytic differentiation. Further, inhibition of ERK5 activity by specific pharmacological agents BIX02189 and XMD8‐92 alters the phenotype of these cells by reducing the abundance of the VDD‐induced surface monocytic marker CD14, and concomitantly increasing surface expression of the general myeloid marker CD11b. Similar results were obtained when the expression of ERK5 was ...
Source: Journal of Cellular Physiology - November 22, 2013 Category: Cytology Authors: Xuening Wang, Stella Pesakhov, Jonathan S Harrison, Michael Danilenko, George P Studzinski Tags: Original Research Article Source Type: research