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Inhibition of CDK7-dependent transcriptional addiction is a potential therapeutic target in synovial sarcoma
Biomed Pharmacother. 2022 Mar 31;149:112888. doi: 10.1016/j.biopha.2022.112888. Online ahead of print.ABSTRACTSynovial sarcoma is typical aggressive malignant without satisfactory treatment outcome in adult series. Cyclin-dependent kinases (CDKs) in transcription have been considered promising molecular targets in cancer. Among these, CDK7 has been shown to play important roles in the pathogenesis of malignancies. However, the modulation mechanism of CDK7-regulated transcription in synovial sarcoma is unknown. In the present study, we aim to determine the expression and function of CDK7 in the transcription cycle of RNA po...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2022 Category: Drugs & Pharmacology Authors: Xiaoyang Li Dylan C Dean Jin Yuan Thomas H Temple Jonathan C Trent Andrew E Rosenberg Shengji Yu Francis J Hornicek Zhenfeng Duan Source Type: research

Cancers, Vol. 12, Pages 1258: Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
This study revealed for the first time the therapeutic potential of TNIK inhibition in synovial sarcoma.
Source: Cancers - May 15, 2020 Category: Cancer & Oncology Authors: Tetsuya Sekita Tesshi Yamada Eisuke Kobayashi Akihiko Yoshida Toru Hirozane Akira Kawai Yuko Uno Hideki Moriyama Masaaki Sawa Yuichi Nagakawa Akihiko Tsuchida Morio Matsumoto Masaya Nakamura Robert Nakayama Mari Masuda Tags: Article Source Type: research

1182PDA novel affinity-enhanced NY-ESO-1-targeting TCR-redirected T cell transfer exhibited early-onset cytokine release syndrome and subsequent tumour responses in synovial sarcoma patients
ConclusionsThe affinity-enhanced NY-ESO-1/TCR-T cell transfer exhibited early-onset CRS in association with in vivo cell proliferation and sequential tumor responses in the patients with high-NY-ESO-1-expressing synovial sarcoma.Clinical trial identificationNCT02366546.Legal entity responsible for the studyThe authors.FundingJapan Agency for Medical Research and Development.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy ‑dependent pathway in human synovial sarcoma cells.
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells. Oncol Rep. 2018 Jul 25;: Authors: Zhu J, Cai Y, Xu K, Ren X, Sun J, Lu S, Chen J, Xu P Abstract Beclin1 is an important autophagy‑related prot-ein, which is involved in both autophagy and apoptosis. In recent years, the antitumor effect of Beclin1 has received increased attention. In the present study, we established a stable Beclin1‑overexpressing cell line with SW982 human synovial sarcoma cells. We found that Beclin1 overexpression decreased the cell viabi...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Down-regulation of miR-10a-5p promotes proliferation and restricts apoptosis via targeting T-box transcription factor 5 in inflamed synoviocytes.
The objective of this study was to observe the role of miR-10a-5p targeting TBX5 gene on synoviocyte proliferation and apoptosis in RA. Human synovial sarcoma cell line, SW982 cells stimulating with IL-1β were transfected with miR-10a-5p mimic and siRNA of TBX5. The real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting analysis were used to evaluate the expression level of miR-10a-5p and TBX5 in SW982 cells, respectively. Further, the proliferation and apoptosis of SW982 cells after treatment were determined by cell counting kit (CCK-8) and flow cytometry analysis respectively. We found that the ...
Source: Bioscience Reports - March 15, 2018 Category: Biomedical Science Authors: Hussain N, Zhu W, Jiang C, Xu J, Geng M, Wu X, Hussain S, Wang B, Rajoka MSR, Li Y, Tian J, Meng L, Lu S Tags: Biosci Rep Source Type: research

Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation.
Abstract MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR-10a-5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR-10a-5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW982 stimulated by IL-1β was determined by RT-qPCR and Western blotting. The direct interaction between miR-10a-5p and TBX5 3'UTR was determined by dual-luciferase reporter assay in HeLa cells. Mimics and inhibitors ...
Source: J Cell Mol Med - August 7, 2017 Category: Molecular Biology Authors: Hussain N, Zhu W, Jiang C, Xu J, Wu X, Geng M, Hussain S, Cai Y, Xu K, Xu P, Han Y, Sun J, Meng L, Lu S Tags: J Cell Mol Med Source Type: research

Down ‐regulation of miR‐10a‐5p in synoviocytes contributes to TBX5‐controlled joint inflammation
Abstract MicroRNAs are considered to play critical roles in the pathogenesis of human inflammatory arthritis, including rheumatoid arthritis (RA). The purpose of this study was to determine the relationship between miR‐10a‐5p and TBX5 in synoviocytes and evaluate their contribution to joint inflammation. The expression of miR‐10a‐5p and TBX5 in the synovium of RA and human synovial sarcoma cell line SW982 stimulated by IL‐1β was determined by RT‐qPCR and Western blotting. The direct interaction between miR‐10a‐5p and TBX5 3′UTR was determined by dual‐luciferase reporter assay in HeLa cells. Mimics and ...
Source: Journal of Cellular and Molecular Medicine - August 7, 2017 Category: Molecular Biology Authors: Nazim Hussain, Wenhua Zhu, Congshan Jiang, Jing Xu, Xiaoying Wu, Manman Geng, Safdar Hussain, Yongsong Cai, Ke Xu, Peng Xu, Yan Han, Jian Sun, Liesu Meng, Shemin Lu Tags: Original Article Source Type: research

EPHB4 tyrosine‐kinase receptor expression and biological significance in soft tissue sarcoma
Abstract Soft tissue sarcomas (STS) are heterogeneous malignant tumors of mesenchymal origin. Due to low incidence and high number of different histological subtypes, their pathogenesis and thus potential targets for their therapy remain barely investigated. Several studies revealed significant higher EPHB4 expression in malignancies such as prostate and colorectal cancer showing survival advantages for these tumor cells. Therefore we studied the expression of EPHB4 in a total of 46 clinical human specimens of different STS and human fibroblasts. EPHB4 mRNA and protein expression were significantly increased in synovial sa...
Source: International Journal of Cancer - October 1, 2014 Category: Cancer & Oncology Authors: M Becerikli, B Merwart, MC Lam, P Suppelna, A Rittig, A Mirmohammedsadegh, I Stricker, C Theiss, B.B. Singer, F Jacobsen, L Steinstraesser Tags: Carcinogenesis Source Type: research