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Total 130 results found since Jan 2013.

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced overexpr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

LncRNA CCAT1 sponges miR-218-5p to promote EMT, cellular migration and invasion of retinoblastoma by targeting MTF2
In conclusion, here we identified the lncRNA CCAT1/miR-218-5p/MTF2 axis in RB cell lines. Our investigations on the function of lncRNA CCAT1 hint a novel biomarker and therapeutic option to facilitate RB diagnosis and treatment.PMID:34265414 | DOI:10.1016/j.cellsig.2021.110088
Source: Cellular Signalling - July 15, 2021 Category: Cytology Authors: Xiangbo Meng Yixia Zhang Yongping Hu Jianguang Zhong Chunming Jiang Hongxu Zhang Source Type: research

Delayed manipulation of regeneration within injured peripheral axons
Neurobiol Dis. 2021 May 1:105383. doi: 10.1016/j.nbd.2021.105383. Online ahead of print.ABSTRACTWhile several new translational strategies to enhance regrowth of peripheral axons have been identified, combined approaches with different targets are rare. Moreover, few have been studied after a significant delay when growth programs are already well established and regeneration-related protein expression has waned. Here we study two approaches, Rb1 (Retinoblastoma 1) knockdown that targets overall neuron plasticity, and near nerve insulin acting as a growth factor. Both are validated to boost regrowth only at the outset of r...
Source: Neurobiology of Disease - May 4, 2021 Category: Neurology Authors: P Komirishetty K Zubkow A Areti H Ong D W Zochodne Source Type: research

Antiangiogenic and Antitumor Therapy for Retinoblastoma with Hypoxia-Inducible Factor-1 & #945; siRNA and Celastrol Co-Delivery Nanomicelles
Source: Journal of Biomedical Nanotechnology - January 11, 2021 Category: Nanotechnology Authors: Yang, Fan Guo, Zhihua Shi, Liuqi Li, Zhanrong Zhang, Junjie Chai, Chang Li, Jingguo Tags: Research Articles Source Type: research

Functional Genomic Analysis of a RUNX3 Polymorphism Associated with Ankylosing Spondylitis
ConclusionsThe findings suggest that the association ofrs4648889 with AS reflects allele ‐specific binding of this enhancer‐like region to certain TFs, including IRF5, IKZF3 and members of the NuRD complex. IRF5 may have crucial influences on CD8+ lymphocyte function that could reveal new therapeutic targets in AS.
Source: Arthritis and Rheumatology - December 26, 2020 Category: Rheumatology Authors: Matteo Vecellio, Liye Chen, Carla J Cohen, Adrian Cortes, Yan Li, Sarah Bonham, Carlo Selmi, Matthew A Brown, Roman Fischer, Julian C Knight, B Paul Wordsworth Tags: FULL LENGTH Source Type: research

MiR-26a inhibits proliferation and apoptosis of uveal melanoma cells via regulating p53/MDM2 pathway.
CONCLUSIONS: Highly expressed miR-26a can inhibit the proliferation and promote apoptosis of SP6.5 cells, whose potential mechanism may be related to the regulation on the p53/MDM2 pathway. PMID: 33277871 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Analysis of the expression and association of retinoblastoma binding protein 6 (RBBP6) with the JNK signaling pathway in prostate cancers.
This study aims to investigate the expression of retinoblastoma binding protein 6 (RBBP6) in prostate cancer (PCa) and its association with the c-Jun N-terminal kinase (JNK) pathway. Immunohistochemistry was used to detect RBBP6 and JNK1/2 expression in PCa and benign prostatic hyperplasia (BPH) tissues. RBBP6 expression in PCa cells (LNCap, PC3 and DU145) and noncancerous prostate epithelial cells (RWPE-1) was determined by qRT-PCR and Western blotting. PC3 and DU145 cells were transfected with RBBP6 siRNAs to examine the biological characteristics. Anisomycin (a JNK activator) with/without RBBP6 siRNA was used to treat P...
Source: Cell Biology International - July 13, 2020 Category: Cytology Authors: Guan WY, Zhao S, Luo YN Tags: Cell Biol Int Source Type: research