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MicroRNA-122 targets δ-catenin to suppress the tumorigenic potential of prostate cancer cells
Am J Cancer Res. 2022 Oct 15;12(10):4853-4864. eCollection 2022.ABSTRACTδ-Catenin is expressed abundantly in various human cancers, including prostate, brain, breast, and lung carcinomas, and is recognized as an oncogene that promotes cancer cell growth and tumorigenesis. Although several transcriptional and post-translational pathways for δ-catenin regulation have been identified in cancer cells, the potential effects of microRNA-mediated regulation remain elusive. Here, we used a δ-catenin 3'-UTR luciferase reporter assay to identify regulatory microRNAs. Subsequent bioinformatics analyses and molecular studies reveal...
Source: Cell Research - November 16, 2022 Category: Cytology Authors: So-Yeon Park Sung Jin Kim Phuong Kim To Rui Zhou Kwonseop Kim Kyung Keun Kim Chaeyong Jung Hangun Kim Source Type: research

GALNT14 promotes cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4
ConclusionGALNT14 promoted the cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4, providing a potential therapeutic target for nasopharyngeal carcinoma treatment.
Source: Molecular and Cellular Toxicology - November 17, 2021 Category: Cytology Source Type: research

KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence
CONCLUSION: The data demonstrates that KIF21A is an important regulator of breast cancer aggressiveness and may be useful in refining prognostication of this malignant disease.PMID:34698969 | DOI:10.1007/s10549-021-06426-x
Source: Cell Research - October 26, 2021 Category: Cytology Authors: Anton J Lucanus Aye Aye Thike Xing Fei Tan Kee Wah Lee Shiyuan Guo Victoria P C King Von Bing Yap Boon Huat Bay Puay Hoon Tan George W Yip Source Type: research

Fluid flow exposure promotes epithelial-to-mesenchymal transition and adhesion of breast cancer cells to endothelial cells
CONCLUSIONS: This study shows that fluid forces on the order of 1 Pa promote EMT and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations. A better understanding of how biophysical forces such as shear stress affect cellular processes involved in metastatic progression of breast cancer is important for identifying new molecular markers for disease progression, and for predicting metastatic risk.PMID:34641959 | DOI:10.1186/s13058-021-01473-0
Source: Cell Research - October 13, 2021 Category: Cytology Authors: Kenneth F Fuh Robert D Shepherd Jessica S Withell Brayden K Kooistra Kristina D Rinker Source Type: research

Prognostic and therapeutic relevance of phosphofructokinase platelet-type (PFKP) in breast cancer.
Abstract In the present study, we have explored the prognostic value of the Phosphofructokinase Platelet-type (PFKP) expression and its therapeutic relevance in metastatic breast cancer. PFKP immunohistochemistry was performed on Invasive ductal carcinomas (IDCs; n = 87) of breast, and its association with clinicopathological parameters were evaluated. Using online meta-analysis tools, PFKP's prognostic value was investigated in overall breast cancer as well as in triple negative subtype (TNBCs). For in vitro analysis, MDA-MB-231 cells model was used in order to elucidate mechanisms behind PFKP regulated gly...
Source: Experimental Cell Research - September 9, 2020 Category: Cytology Authors: Umar SM, Kashyap A, Kahol S, Mathur S, Gogia A, Deo SVS, Prasad CP Tags: Exp Cell Res Source Type: research

Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.
CONCLUSION: These results suggest that CYC1 inhibits cell proliferation, glycolytic activity and increases chemosensitivity to paclitaxel in ER-positive breast carcinoma cells and that CYC1 status is a potent favorable prognostic factor in ER-positive breast cancer patients. PMID: 31149728 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - June 4, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research

The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III
Conclusion: EGFRvIII could induce autophagy, and CH12 treatment could improve autophagy activity in EGFRvIII-positive liver cancer cells. The combination of CH12 with an autophagy inhibitor or siRNA against key proteins in the autophagy pathway displayed more significant efficacy on EGFRvIII-positive tumor cells than monotherapy, and induced cell apoptosis.Cell Physiol Biochem 2018;46:226 –237
Source: Cellular Physiology and Biochemistry - March 26, 2018 Category: Cytology Source Type: research

Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Conclusions: In this study, we found that radiation up-regulated the expression of ATF4. We used ATF4 knockdown and over-expression systems to show that ATF4 may play a role in radiation-induced cellular apoptosis.Cell Physiol Biochem 2017;41:784 –794
Source: Cellular Physiology and Biochemistry - February 10, 2017 Category: Cytology Source Type: research

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.
Abstract Adhesion G protein-coupled receptors (ADGRs) are believed to be activated by auto-proteolytic cleavage of their very large extracellular N-terminal domains normally acting as a negative regulator of the intrinsically constitutively active seven transmembrane domain. ADGRG2 (or GPR64) which originally was described to be expressed in the epididymis and studied for its potential role in male fertility, is highly up-regulated in a number of carcinomas, including breast cancer. Here, we demonstrate that ADGRG2 is a functional receptor, which in transfected HEK293 cells signals with constitutive activity throu...
Source: Cellular Signalling - August 27, 2015 Category: Cytology Authors: Peeters MC, Fokkelman M, Boogaard B, Egerod KL, van de Water B, IJzerman AP, Schwartz TW Tags: Cell Signal Source Type: research

Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells.
Abstract The Eph and Ephrin proteins, which constitute the largest family of receptor tyrosine kinases, are involved in normal tissue development and cancer progression. Here, we examined the expression and role of the B-type Eph receptor EphB2 in breast cancers. By immunohistochemistry using a progression tissue microarray of human clinical samples, we found EphB2 to be expressed in benign tissues, but strongly increased in cancers particularly in invasive and metastatic carcinomas. Subsequently, we found evidence that EphB2, whose expression varies in established cell breast lines, possesses multiple functions. ...
Source: Experimental Cell Research - November 6, 2013 Category: Cytology Authors: Chukkapalli S, Amessou M, Kumar Dilly A, Dekhil H, Zhao J, Liu Q, Bejna A, Thomas RD, Bandyopadhyay S, Bismar TA, Neill D, Azoulay L, Batist G, Kandouz M Tags: Exp Cell Res Source Type: research

CCL20 induces migration and proliferation on breast epithelial cells
Abstract The communication between the tumour cells and the surrounding cells helps drive the process of tumour progression. Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology of healthy breast epithelial cells in areas adjacent to the tumour. Therefore, primary cultures of mammary cells taken from normal peritumoral areas were used. We assessed that breast cells expressed CCR6 CCL20 receptor. Using molecular (siRNA) and pharmacological (inhibitors) techniques we found multiple signalling kinases to be activated by CCR6 and...
Source: Journal of Cellular Physiology - March 4, 2013 Category: Cytology Authors: Santo Marsigliante, Carla Vetrugno, Antonella Muscella Tags: Original Research Article Source Type: research