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Cancer: Breast Carcinoma

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Total 244 results found since Jan 2013.

The prognostic value of DAAM2 in lower grade glioma, liver cancer, and breast cancer
CONCLUSION: DAAM2 had a specific value in foretelling the prognosis of LGG, LIHC, and BRCA. High expression level of DAAM2 has longer survival rates in LGG and LIHC. The knockdown of DAAM2 retards the proliferation, invasion, and migration of BRCA cells. This study provides a novel sight of DAAM2 into the exploration of a potential biomarker in pan-cancer.PMID:36790676 | DOI:10.1007/s12094-023-03111-x
Source: Clinical Genitourinary Cancer - February 15, 2023 Category: Cancer & Oncology Authors: Zeying Li Xiao Wei Yichao Zhu Source Type: research

CCN6 Knockdown Disrupts Acinar Organization of Breast Cells in Three-dimensional Cultures through Up-regulation of Type III TGF-β Receptor.
Abstract While normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) disrupts breast epithelial cell polarity and organization into acini through up-regulation of the type III transforming growth factor-β receptor (TβRIII or betaglycan). Down-regulation of CCN6 in benign breast cells led to loss of tissue polarity and resulted in cellular disorganization with l...
Source: Neoplasia - November 1, 2012 Category: Cancer & Oncology Authors: Pal A, Huang W, Toy KA, Kleer CG Tags: Neoplasia Source Type: research

Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Abstract Matrix metalloproteinase-9 (MMP-9) plays a crucial role in tumor metastasis. Previous studies showed that polyunsaturated fatty acids exhibit an anti-cancer effect in various human carcinoma cells, but the effect of docosahexaenoic acid (DHA) and linoleic acid (LA) on metastasis of breast cancer cells is not fully clarified. We studied the anti-metastasis potential of DHA and LA in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MCF-7 cells. We found that TPA (100 ng/ml) induced MMP-9 enzyme activity both dose- and time-dependently, and 200 μM DHA and LA significantly inhibited MMP-9 mRNA and protei...
Source: Archives of Toxicology - January 4, 2013 Category: Toxicology Authors: Chen HW, Chao CY, Lin LL, Lu CY, Liu KL, Lii CK, Li CC Tags: Arch Toxicol Source Type: research

CCL20 induces migration and proliferation on breast epithelial cells
Abstract The communication between the tumour cells and the surrounding cells helps drive the process of tumour progression. Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology of healthy breast epithelial cells in areas adjacent to the tumour. Therefore, primary cultures of mammary cells taken from normal peritumoral areas were used. We assessed that breast cells expressed CCR6 CCL20 receptor. Using molecular (siRNA) and pharmacological (inhibitors) techniques we found multiple signalling kinases to be activated by CCR6 and...
Source: Journal of Cellular Physiology - March 4, 2013 Category: Cytology Authors: Santo Marsigliante, Carla Vetrugno, Antonella Muscella Tags: Original Research Article Source Type: research

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins
In conclusion, our data demonstrate a role for ADAM12 in ectodomain shedding of several membrane-anchored endothelial proteins. We speculate that this process may have importance in tumour neovascularization or/and tumour-cell extravasation.
Source: BJ Cell - March 5, 2013 Category: Biochemistry Authors: C Fröhlich, M Klitgaard, J B Noer, A Kotzsch, C Nehammer, P Kronqvist, J Berthelsen, C Blobel, M Kveiborg, R Albrechtsen, U M Wewer Tags: BJ Cell Source Type: research

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
In conclusion, the results of the present study demonstrate a role for ADAM12 in ectodomain shedding of several membrane-anchored endothelial proteins. We speculate that this process may have importance in tumour neovascularization or/and tumour cell extravasation. PMID: 23458101 [PubMed - in process]
Source: The Biochemical Journal - May 15, 2013 Category: Biochemistry Authors: Fröhlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM Tags: Biochem J Source Type: research

Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.
Abstract Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by enhancing cancer cell migration and invasion. Phosphatidylinositol 3-kinase γ (PI3Kγ) is specifically activated by GPCRs. The goal of the present study was to determine the role of PI3Kγ in breast cancer cell migration and invasion. Immunohistochemical staining showed that the expression of PI3Kγ protein was significantly increased in invasive human breast carcinoma when compared to adjacent benign breast tissue or ductal carcinom...
Source: Biochemical Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, Wolff DW, Toews ML, Tu Y Tags: Biochem Pharmacol Source Type: research

Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance.
CONCLUSION: Our findings indicated that Annexin A3 might be a novel and potential prognostic marker for patients with breast cancer and be involved in regulating apoptosis by affecting Bcl-2/Bax balance. PMID: 23631820 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - April 28, 2013 Category: Pathology Authors: Zeng C, Ke Z, Song Y, Yao Y, Hu X, Zhang M, Li H, Yin J Tags: Exp Mol Pathol Source Type: research

In Vitro and In Vivo Effects of Phenethyl Isothiocyanate Treatment on Vimentin Protein Expression in Cancer Cells.
Abstract We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression. Because suppression of E-cadherin protein concomitant with induction of mesenchymal markers (e.g., vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. Contrary to this prediction, exposure of human breast (MDA-MB-231) and prostate...
Source: Nutrition and Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Sakao K, Hahm ER, Singh SV Tags: Nutr Cancer Source Type: research

In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cells.
Abstract We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression. Because suppression of E-cadherin protein concomitant with induction of mesenchymal markers (e.g., vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. Contrary to this prediction, exposure of human breast (MDA-MB-231) and prostate...
Source: Nutrition and Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Sakao K, Hahm ER, Singh SV Tags: Nutr Cancer Source Type: research

Novel XBP1-regulated Endoplasmic Stress Response Element Gene Regulation
Understanding the regulatory mechanisms mediating PRNP gene expression is highly relevant to elucidating normal cellular prion protein (PrP) function(s) and the transmissibility of prion protein neurodegenerative diseases. Here, luciferase reporter assays showed that an endoplasmic reticulum stress element (ERSE)-like element, CCAAT-N26-CCACG in the human PRNP promoter, is regulated by ER stress and X-box-binding protein 1 (XBP1) but not by activating transcription factor 6 α (ATF6α). Bioinformatics identified the ERSE-26 motif in 37 other human genes in the absence of canonical ERSE sites except for three genes. Several...
Source: Journal of Biological Chemistry - July 12, 2013 Category: Chemistry Authors: Misiewicz, M., Dery, M., Foveau, B., Jodoin, J., Ruths, D., LeBlanc, A. C. Tags: Gene Regulation Source Type: research

WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells
Abstract: An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show that recombinant WNT-5A activates the Cdc42 in breast cancer cells (lines MDA-MB468 and MDA-MB231) in a time-dependent manner. Activation of Cdc42 was also observed in MDA-MB468 cells that were stably transfected with a...
Source: Molecular Oncology - May 3, 2013 Category: Cancer & Oncology Authors: Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, Lena Axelsson, Tommy Andersson Tags: Research Articles Source Type: research

Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells.
Abstract The Eph and Ephrin proteins, which constitute the largest family of receptor tyrosine kinases, are involved in normal tissue development and cancer progression. Here, we examined the expression and role of the B-type Eph receptor EphB2 in breast cancers. By immunohistochemistry using a progression tissue microarray of human clinical samples, we found EphB2 to be expressed in benign tissues, but strongly increased in cancers particularly in invasive and metastatic carcinomas. Subsequently, we found evidence that EphB2, whose expression varies in established cell breast lines, possesses multiple functions. ...
Source: Experimental Cell Research - November 6, 2013 Category: Cytology Authors: Chukkapalli S, Amessou M, Kumar Dilly A, Dekhil H, Zhao J, Liu Q, Bejna A, Thomas RD, Bandyopadhyay S, Bismar TA, Neill D, Azoulay L, Batist G, Kandouz M Tags: Exp Cell Res Source Type: research

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis.
Abstract Guanine nucleotide-binding protein (G protein), alpha activating activity polypeptide O (GNAO1) encodes an alpha subunit of the heterotrimeric guanine nucleotide-binding proteins (Gαo), which plays a significant role in the development of various types of cancer, including breast cancer and hepatocellular carcinoma. However, its role in gastric cancer (GC) has not yet been elucidated. In the current study, the expression of Gαo was analyzed by immunohistochemistry in paraffin-embedded tissue sections from 70 patients with GC and its cellular role was examined by small interfering RNA (siRNA)-mediated...
Source: International Journal of Molecular Medicine - December 20, 2013 Category: Molecular Biology Authors: Liu Z, Zhang J, Wu L, Liu J, Zhang M Tags: Int J Mol Med Source Type: research

Early animal research into blocking breast cancer
"'An injection that prevents breast cancer is being developed by scientists," is the news on the Mail Online website. This news seems a heartening way to start the year, but a caveat is that the research is in the very early stages – as yet only tested in mice. The researchers were interested in a type of breast cancer known as ductal carcinoma in situ (DCIS). In DCIS the cancerous cells are contained within the ducts in the breast, and not spread to other breast tissue. The problem with DCIS is that it is currently impossible to predict whether the cancer will remain inside the duct (so will not require tr...
Source: NHS News Feed - January 2, 2014 Category: Consumer Health News Tags: Cancer Source Type: news