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lncRNA OGFRP1 promotes tumor progression by activating the AKT/mTOR pathway in human gastric cancer
Aging (Albany NY). 2021 Mar 19;13. doi: 10.18632/aging.202731. Online ahead of print.ABSTRACTAs biomolecules of great clinical value, lncRNAs play a crucial role as regulators in the processes of tumor origin, metastasis, and recurrence. Thus, lncRNAs are urgently needed for research in gastric cancer. We elucidated the specific function of OGFRP1, both in vitro and in vivo. OGFRP1 was expressed at abnormally high levels in gastric cancer samples (n = 408) compared to normal samples (n = 211). Similar results were obtained in 30 clinical case samples. Interference of OGFRP1 markedly blocked cell proliferation and migration...
Source: Aging - March 21, 2021 Category: Biomedical Science Authors: Jingzhou Zhang Xiujuan Xu Junfeng Yin Jiaqi Tang Nan Hu Yidong Hong Ziyan Song Baoxiang Bian Fenglei Wu Source Type: research

Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer.
Abstract HOXA6 gene plays a role of the oncogene in various cancers. Nonetheless, its effect on gastric cancer (GC) occurrence and development is still unclear. We analysed whether HOXA6 interacts with the PBX2 protein using the STRING database. The molecular mechanism by which HOXA6 synergizes with PBX2 in GC metastasis is not fully understood. Here, we found that the expression of HOXA6 was increased in GC tissues and cell lines. The upregulation of HOXA6 was closely associated with differentiation, lymph node metastasis, AJCC stage, TNM stage, and poor survival outcome in GC patients based on tissue microarray ...
Source: Aging - February 1, 2021 Category: Biomedical Science Authors: Lin J, Zhu H, Hong L, Tang W, Wang J, Hu H, Wu X, Chen Y, Liu G, Yang Q, Li J, Wang Y, Lin Z, Xiao Y, Dai W, Huang M, Li G, Li A, Wang J, Xiang L, Liu S Tags: Aging (Albany NY) Source Type: research

Circular RNA hsa-circ-0007766 modulates the progression of Gastric Carcinoma via miR-1233-3p/GDF15 axis.
This study unveils a mechanism by which hsa-circ-0007766 regulates GDF15 via hsa-circ-0007766/miR-1233-3p/GDF15 axis, which may provide new insight for GC therapeutic strategies. PMID: 32669960 [PubMed - in process]
Source: International Journal of Medical Sciences - July 17, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

RON and RON Δ160 promote gastric cancer cell proliferation, migration, and adaption to hypoxia via interaction with β-catenin.
RON and RONΔ160 promote gastric cancer cell proliferation, migration, and adaption to hypoxia via interaction with β-catenin. Aging (Albany NY). 2019 May 13;: Authors: Zhou D, Huang L, Zhou Y, Wei T, Yang L, Li C Abstract Aberrant accumulation of the receptor tyrosine kinase recepteur d'origine nantais (RON) has been verified in gastric adenocarcinoma. Upregulation of RON and its splice variant RONΔ160 contribute to the growth and migration in gastric cancer cells in vitro. However, the mechanisms of RON/RONΔ160-mediated gastric cancer growth and metastasis remain vague. We therefore examined the ...
Source: Aging - May 12, 2019 Category: Biomedical Science Authors: Zhou D, Huang L, Zhou Y, Wei T, Yang L, Li C Tags: Aging (Albany NY) Source Type: research

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and  mechanism in gastric cancer cell growth and metastasis.
CONCLUSION: Collectively, our study highlights that the high expression of miR-27a indicates the poor efficacy and prognosis of neoadjuvant chemotherapy in GC patients. Down-regulation of miR-27a can inhibit the growth and metastasis of GC cells via up-regulation of SFRP1. PMID: 30902884 [PubMed - as supplied by publisher]
Source: Bioscience Reports - March 21, 2019 Category: Biomedical Science Authors: Xu C, Cheng H, Li N, Zhou N, Tang X Tags: Biosci Rep Source Type: research

Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm
This study indicates that the acquisition of TFF1 expression is an early event in pancreatic carcinogenesis and that TFF1 might act as a tumor suppressor to prevent EMT and the invasive transformation of PanIN.
Source: Journal of Clinical Investigation - July 23, 2018 Category: Biomedical Science Authors: Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Tomoki Ebata, Atsushi Enomoto, Masato Nagino Source Type: research

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase {alpha}, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521 RESEARCH ARTICLE
ABSTRACT Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific receptors. Recently, we found that VacA induced the phosphorylation of cellular Src kinase (Src) at Tyr418 in AZ-521 cells. Silencing of receptor protein tyrosine phosphatase (RPTP)α, a VacA receptor, reduced VacA-induced Src phosphorylation. Src is responsible for tyrosine phosphorylation of CagA at its Glu-Pro-Ile-Tyr-Ala (EPIYA) variant C (EPIYA-C) m...
Source: DMM Disease Models and Mechanisms - December 6, 2016 Category: Biomedical Science Authors: Nakano, M., Yahiro, K., Yamasaki, E., Kurazono, H., Akada, J., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T., Moss, J., Isomoto, H., Hirayama, T. Tags: RESEARCH ARTICLE Source Type: research

Down-regulation of anti-apoptotic genes in tumor cell lines is facilitated by suppression of OCT4B1
Conclusions It may possibly be concluded that suppression of OCT4B1 can lead to apoptosis in tumor cell lines and this is at least facilitated via down-regulation of examined anti-apoptotic genes. Accordingly, suppression of OCT4B1 may probably be considered as useful tool in cancer therapy and research.
Source: Advances in Medical Sciences - May 10, 2016 Category: Biomedical Science Source Type: research

BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells.
In conclusion, siRNA-mediated BARF1 down-regulation induces caspase-dependent apoptosis via the mitochondrial pathway through modulation of Bcl-2/BAX ratio in AG876 and Hone-Akata cells. Targeting BARF1 using siRNA has the potential to be developed as a novel therapeutic strategy in the treatment of EBV-associated malignancies. PMID: 25740140 [PubMed - as supplied by publisher]
Source: Journal of Biosciences - March 1, 2015 Category: Biomedical Science Authors: Mohidin TB, Ng CC Tags: J Biosci Source Type: research

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/Erk-dependent pathways.
In conclusion, these results indicate that PAK4 confers CDDP resistance via activation of MEK/Erk and PI3K/Akt pathways. PAK4 and PI3K/Akt pathways can reciprocally activate each other. Therefore, PAK4 may be a potential target for overcoming CDDP resistance in gastric cancer. PMID: 24471762 [PubMed - as supplied by publisher]
Source: Bioscience Reports - January 29, 2014 Category: Biomedical Science Authors: Fu X, Feng J, Zeng D, Ding Y, Yu C, Yang B Tags: Biosci Rep Source Type: research