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Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to Helicobacter pylori
Helicobacter pylori (H. pylori) is one of the gram-negative bacteria that mainly colonize the stomach mucosa and cause many gastrointestinal diseases, such as gastritis, peptic ulcer, and gastric cancer. Macrophages play a key role in eradicating H. pylori. Recent data have shown that Notch signaling could modulate the activation and bactericidal activities of macrophages. However, the role of Notch signaling in macrophages against H. pylori remains unclear. In the present study, in the co-culture model of macrophages with H. pylori, the inhibition of Notch signaling using γ-secretase decreased the expression of inducible...
Source: Frontiers in Microbiology - July 8, 2021 Category: Microbiology Source Type: research

Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells.
Conclusion: The present study demonstrated that HOTAIR was highly expressed in GC tissues and may serve as a potential diagnostic and prognostic biomarker for GC. And HOTAIR promoted GC cell proliferation. PMID: 31281803 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - July 11, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Activation of FXR promotes intestinal metaplasia of gastric cells via SHP-dependent upregulation of the expression of CDX2.
Authors: Zhou H, Ni Z, Li T, Su L, Zhang L, Liu N, Shi Y Abstract Gastric intestinal metaplasia (IM) induced by bile acid is a precancerous lesion of gastric adenocarcinoma and is associated with the expression of caudal-related homeobox 2 (CDX2). In the present study, the role of farnesoid X receptor (FXR) on the regulation of CDX2 in gastric cells was investigated and the underlying molecular mechanisms were examined. Human gastric cell lines were treated with chenodeoxycholic acid (CDCA) or FXR agonist GW4064. Cells were treated with CDCA in the presence or absence of the FXR antagonist or FXR siRNA transfection...
Source: Oncology Letters - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA ‐329 inhibits cell proliferation and tumor growth while facilitates apoptosis via negative regulation of KDM1A in gastric cancer
Conclusion: We conclude that miRNA‐329 functions as a tumor suppressor in GC, which could be achieved via transcriptional suppression of KDM1A. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - November 11, 2017 Category: Biochemistry Authors: Lisheng Cai, Qiuxian Chen, Shunyong Fang, Mingqiao Lian, Mingzhi Cai Tags: Article Source Type: research

MicroRNA ‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3
ConclusionsTaken all together, Tip‐α might activate NF‐κB to promote inflammation and carcinogenesis by inhibiting miR‐3178 expression, which directly targeting TRAF3, during H. pylori infection in gastric mucosal epithelial cells.
Source: Helicobacter - July 31, 2016 Category: Gastroenterology Authors: Meijuan Zou, Fang Wang, Aiqin Jiang, Anliang Xia, Siya Kong, Chun Gong, Mingxia Zhu, Xin Zhou, Jun Zhu, Wei Zhu, Wenfang Cheng Tags: Original Article Source Type: research

TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling.
Authors: Peng Y, Zhao Q, Zhang H, Han B, Liu S, Han M, Liu S Abstract Targeted inhibition of specific toll-like receptor (TLR) pathways may provide an effective strategy to prevent the development of selected gastric malignancies. Tumor necrosis factor (TNF)-α-induced protein 8-like-2 (TIPE2) was identified as a novel negative regulator of TLR signaling. Our previous study identified TIPE2 as an inhibitor of gastric cancer cell growth; it promotes p27 expression, which leads to restored control of the cell cycle and cell division. However, the molecular mechanism by which TIPE2 regulates p27 remains unclear. In th...
Source: Oncology Reports - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research