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Total 71193 results found since Jan 2013.
Management of chemotherapy hypersensitivity reactions and desensitization: An SGO clinical practice statement
CONCLUSION: Incorporating a review of the literature and clinical experience from the SGO Education Committee, this paper provides an overview of current approaches for prevention and management of reactions to commonly used chemotherapy agents for gynecologic cancers.PMID:37717346 | DOI:10.1016/j.ygyno.2023.08.017
Source: Gynecologic Oncology - September 17, 2023 Category: Cancer & Oncology Authors: T R Hall J E MacDonald K M Bylinowski E A Alvarez M M Hardesty J A Smith Source Type: research
Carboplatin-induced upregulation of pan β-tubulin and class III β-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer
Cell Mol Life Sci. 2023 Sep 17;80(10):294. doi: 10.1007/s00018-023-04943-0.ABSTRACTResistance to platinum- and taxane-based chemotherapy represents a major obstacle to long-term survival in ovarian cancer (OC) patients. Here, we studied the interplay between acquired carboplatin (CBP) resistance using two OC cell models, MES-OV CBP and SK-OV-3 CBP, and non-P-glycoprotein-mediated cross-resistance to paclitaxel (TAX) observed only in MES-OV CBP cells. Decreased platination, mesenchymal-like phenotype, and increased expression of α- and γ-tubulin were observed in both drug-resistant variants compared with parental cells. B...
Source: Cellular and Molecular Life Sciences : CMLS - September 17, 2023 Category: Cytology Authors: Margareta Pernar Kova č Vanja Tadi ć Juran Kralj George E Duran Alessia Stefanelli Darija Stupin Polan čec Sanja Dabeli ć Niko Ba čić Maja T Tomicic Petra Heffeter Branimir I Sikic Anamaria Brozovic Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
Biomarkers-Based Cost-Effectiveness of Toripalimab Plus Chemotherapy for Patients with Treatment-Naive Advanced Non-Small Cell Lung Cancer
CONCLUSION: From the perspective of the Chinese healthcare system, this study's findings suggested that first-line TC represents a cost-effective strategy for patients with advanced NSCLC. However, the cost-effectiveness of first-line TC varied across different subgroups when considering predictive biomarkers.PMID:37715852 | DOI:10.1007/s12325-023-02679-8
Source: Adv Data - September 16, 2023 Category: Epidemiology Authors: Huixian Zhang Lanfang Li Lei Feng Zhen Zhou Xin Zhang Jianbo Feng Qiao Liu Source Type: research
Adult Laryngeal Pleomorphic Rhabdomyosarcoma: A Rare Entity
Ear Nose Throat J. 2023 Sep 16:1455613231198986. doi: 10.1177/01455613231198986. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is a rare and aggressive cancerous tumor that arises from embryonal mesenchymal cells with skeletal muscle differentiation, and it is exceedingly rare that occurs specifically in the larynx. To date, only 22 instances of laryngeal pleomorphic RMSs have been documented in adults. Consequently, there is limited information available to assist healthcare professionals in effectively handling RMS in the larynx of adult patients. Here, we present an uncommon occurrence involving a 45-year-old man...
Source: Ear, Nose and Throat Journal - September 16, 2023 Category: ENT & OMF Authors: Hua Cai Shan Chen Zhuo-Ya Zhang Bei-Bei Gao Yan-Yan Ding Bang-Hua Liu Wen-Wen Wang Source Type: research
Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3 β/β-catenin signaling in Wistar rats
This study aimed at investigating the effects of chronic treatment with amisulpride (5 mg/kg/day) in the management of 5-fluorouracil (5-FU)-induced cognitive deficits in Wistar rats. Rats received 5 intraperitoneal injections of 5-FU (25 mg/kg every 3 days). 5-FU treatment induced impairments in spatial learning (reduction in object location discrimination ratio) and non-spatial learning (reduction in novel object recognition discrimination ratio). Moreover, 5-FU induced a decrease in the activity of the Wnt/GSK-3β/β-catenin pathway with a decrease in brain-derived neurotrophic factor (BDNF) level in the hippocampus. Th...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Radwa S Raafat Mohamed Z Habib Amany A AbdElfattah Nouran K Olama Sahar M Abdelraouf Nevien Hendawy Khaled A Kamal Salwa A Nawishy Sawsan Aboul-Fotouh Source Type: research
Reirradiation with advanced brachytherapy techniques in recurrent GYN cancers
CONCLUSION: The use of advanced BT approach in reirradiation setting is a feasible and safe option in treatment of post-treatment recurrent cervical, endometrial, and vaginal cancers.PMID:37716821 | DOI:10.1016/j.brachy.2023.07.004
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Umesh Mahantshetty Sheetal R Kashid Gargee Mulye Lavanya Gurram Reena Engineer Supriya Chopra Jaya Ghosh Seema Gulia Sudeep Gupta Yogesh Ghadi Dheera A Satish Kohle Sudarshan Kadam Santosh Menon Kedar Deodhar Amita Maheswari Shylasree T S Shirley Lewis Ni Source Type: research
SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis
CONCLUSIONS: Collectively, our findings identify SRRM4 as a regulator of brain metastasis colonization, and a potential therapeutic target in breast cancer.PMID:37716001 | DOI:10.1093/neuonc/noad175
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Krutika Deshpande Vahan Martirosian Brooke N Nakamura Diganta Das Mukund Iyer Max Reed Ling Shao Daniella Bamshad Noel J Buckley Josh Neman Source Type: research
A review of recent advancements in Actinium-225 labeled compounds and biomolecules for therapeutic purposes
Chem Biol Drug Des. 2023 Sep 15. doi: 10.1111/cbdd.14311. Online ahead of print.ABSTRACTIn nuclear medicine, cancers that cannot be cured or can only be treated partially by traditional techniques like surgery or chemotherapy are killed by ionizing radiation as a form of therapeutic treatment. Actinium-225 is an alpha-emitting radionuclide that is highly encouraging as a therapeutic approach and more promising for targeted alpha therapy (TAT). Actinium-225 is the best candidate for tumor cells treatment and has physical characteristics such as high (LET) linear energy transfer (150 keV per μm), half-life (t1/2 = 9.92d), a...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Maria Hassan Tanveer Hussain Bokhari Nadeem Ahmed Lodhi Muhammad Kaleem Khosa Muhammad Usman Source Type: research
Progress in the treatment of drug-loaded nanomaterials in renal cell carcinoma
This article reviews the use of nanomaterials, such as liposomes, polymeric nanoparticles, nanocomposites, carbon nanomaterials, nanobubbles, nanomicelles, and mesoporous silica nanoparticles, for RCC treatment, and discusses their advantages and disadvantages.PMID:37716114 | DOI:10.1016/j.biopha.2023.115444
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Jianyang Li Kunzhe Wu Jinmei Zhang Huan Gao Xiaohua Xu Source Type: research
The combination of the HDC1 inhibitor SAHA and doxorubicin has synergic efficacy in triple negative breast cancer in vivo
In this study, we investigated the synergistic potential of these two drugs in combination against TNBC. Our results suggested that the combination of these two drugs could enhance the inhibitory effect on cancer cell proliferation, resulting in alterations in cell mitotic phase, and suppression of cancer cell stemness. Moreover, our in vivo study unveiled that when SAHA was combined with DOX, it not only exhibited an inhibitory effect on tumor metastasis but also played a role in regulating the immune microenvironment within tumors. Overall, the combination of DOX and SAHA presents a promising avenue for innovative combin...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Yuheng Pang Runze Shi Liujia Chan Yu Lu Di Zhu Tong Liu Meisi Yan Yuji Wang Wenjing Wang Source Type: research
Pathologic response to neoadjuvant chemotherapy in ovarian cancer and its association with outcome: A surrogate marker of survival
CONCLUSIONS: We validate a three-tier CRS for assessment of pathologic response to NACT in OC and demonstrate its prognostic independence of BRCA status or neoadjuvant bevacizumab use. Improving pR rates may be a useful goal of NACT in OC with the expectation of improved survival. The CRS may be a useful endpoint in clinical trials in OC.PMID:37716223 | DOI:10.1016/j.ygyno.2023.09.002
Source: Gynecologic Oncology - September 16, 2023 Category: Cancer & Oncology Authors: Leah A Marsh Teresa H Kim Mingyan Zhang Kari Kubalanza Charisse Liz Treece Dana Chase Sanaz Memarzadeh Ritu Salani Beth Karlan Jianyu Rao Gottfried E Konecny Source Type: research
Adoption of nanoparticle micro-infusion valve in venous port access for tumor patients and self-care analysis
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):91-97. doi: 10.14715/cmb/2023.69.7.15.ABSTRACTIt aimed to discuss the adoption of nanoparticle micro-infusion valves in the totally implantable venous access port (TIVAP) of tumor patients and analyze the self-care of patients after surgery. A total of 189 tumor patients who received TIVAP chemotherapy were selected from the day chemotherapy outpatient department of the Second People's Hospital of Lianyungang City from June to October 2021. The questionnaire survey was conducted to collect and analyze the general information about the patients and the patient's self-care ab...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lijuan Sun Hui Xu Qing Wang Source Type: research
