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Specialty: Cardiology
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Total 109613 results found since Jan 2013.
Single-Cell RNA Sequencing Reveals Cellular Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress
CONCLUSIONS: We showed that flow shear stress modulates the cellular capacity of ECs to respond to paclitaxel and rapamycin administration, suggesting that while responding to different flow patterns, ECs experience an impairment in their transcriptional adaptation to other stimuli.PMID:37732484 | DOI:10.1161/ATVBAHA.123.319283
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Antonio G Salazar-Mart ín Aditya S Kalluri Martin A Villanueva Travis K Hughes Marc H Wadsworth Ii Tyler T Dao Mercedes Balcells Farhad R Nezami Alex K Shalek Elazer R Edelman Source Type: research
Aging Is Associated With Organ-Specific Alterations in the Level and Expression Pattern of von Willebrand Factor
CONCLUSIONS: Aging elicits a heterogenic response in endothelial cells with regard to VWF expression, leading to organ-specific increase in VWF levels and alterations in vascular tree pattern of expression. This is concomitant with increased platelet aggregate formation. The age-associated increase in VWF expression may be modulated through the process of cell senescence, and p53 transcription factor contributes to its regulation.PMID:37732483 | DOI:10.1161/ATVBAHA.123.319255
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Parnian Alavi Radya Yousef Abdualla Douglas Brown Anahita Mojiri Jayan Nagendran John Lewis Stephane L Bourque Nadia Jahroudi Source Type: research
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
medRxiv. 2023 Sep 7:2023.09.05.23295093. doi: 10.1101/2023.09.05.23295093. Preprint.ABSTRACTClonal hematopoiesis (CH), characterized by blood cells predominantly originating from a single mutated hematopoietic stem cell, is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CH is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk in Communities Study (ARIC) participants over a me...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Md Mesbah Uddin Seyedmohammad Saadatagah Abhishek Niroula Bing Yu Whitney Hornsby Shriienidhie Ganesh Kim Lannery Art Shuermans Michael C Honigberg Alexander G Bick Peter Libby Benjamin L Ebert Christie M Ballantyne Pradeep Natarajan Source Type: research
Cardiac microRNAs: diagnostic and therapeutic potential
Arch Med Sci. 2023 Aug 25;19(5):1360-1381. doi: 10.5114/aoms/169775. eCollection 2023.ABSTRACTMicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. In cardiovascular disease pathophysiology, there are several cells that produce microRNAs, including endothelial cells, vascular smooth muscle cells, macrophages, platelets, and cardiomyocytes. There is a constant crosstalk between microRNAs derived from variou...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Anna Kab łak-Ziembicka Rafa ł Badacz Micha ł Okarski Magdalena Wawak Tadeusz Przew łocki Jakub Podolec Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Smoking, immunity, and cardiovascular prognosis: a study of plasma IgE concentration in patients with acute myocardial infarction
CONCLUSION: Cotinine exhibits a positive association with AMI, wherein IgE plays a mediating role. Elevated plasma levels of IgE was positively associated with AMI and poor prognosis, which further confirms the adverse role of smoking on the incidence of AMI and prognosis. (Clinical trial registration: ChiCTR2100053000).PMID:37731521 | PMC:PMC10508960 | DOI:10.3389/fcvm.2023.1174081
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Lili Zhang Yanrong Zhu Xin Meng Yifan Zhang Qian Ren Dong Huang Zhong Chen Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
AI diagnosis of heart sounds differentiated with super StethoScope
J Cardiol. 2023 Sep 19:S0914-5087(23)00229-0. doi: 10.1016/j.jjcc.2023.09.007. Online ahead of print.ABSTRACTIn the aging global society, heart failure and valvular heart diseases, including aortic stenosis, are affecting millions of people and healthcare systems worldwide. Although the number of effective treatment options has increased in recent years, the lack of effective screening methods is provoking continued high mortality and rehospitalization rates. Appropriately, auscultation has been the primary option for screening such patients, however, challenges arise due to the variability in auscultation skills, the obje...
Source: Journal of Cardiology - September 21, 2023 Category: Cardiology Authors: Shimpei Ogawa Fuminori Namino Tomoyo Mori Ginga Sato Toshitaka Yamakawa Shumpei Saito Source Type: research
Prevalence of atrial septal defects and patent foramen ovale in a cohort of sudden cardiac death patients undergoing autopsy
CONCLUSIONS: The combined rate of PFO and ASD in a cohort of 517 patients undergoing autopsy was 7.9 %. None of these patients had experienced a cerebrovascular accident. This rate of PFOs appears lower than earlier reports and raises the possibility that the relative risk of an associated stroke could be higher than previously estimated.PMID:37734655 | DOI:10.1016/j.jjcc.2023.09.006
Source: Journal of Cardiology - September 21, 2023 Category: Cardiology Authors: Louise Fahy Stephanie Rowe Ziad Nehme Dion Stub Dominica Zentner Paul James Andreas Pflaumer Vanessa Connell Christopher Semsarian Jodie Ingles Andre La Gerche Elizabeth D Paratz Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
CONCLUSIONS: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use.PMID:37732457 | DOI:10.1161/CIRCULATIONAHA.122.060315
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Stuart J Connolly Jeff S Healey Emilie P Belley-Cote Kumar Balasubramanian Domenico Paparella Katheryn Brady Wilko Reents Bernhard C Danner P J Devereaux Mukul Sharma Chinthanie Ramasundarahettige Salim Yusuf Richard P Whitlock Source Type: research
Existing Nongated CT Coronary Calcium Predicts Operative Risk in Patients Undergoing Noncardiac Surgeries (ENCORES)
CONCLUSIONS: Prevalence and severity of coronary calcium obtained from existing nongated chest CT imaging improve preoperative clinical risk stratification before nongated surgery.PMID:37732454 | DOI:10.1161/CIRCULATIONAHA.123.064398
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Y Choi Dena Hayes Samuel D Maidman Nehal Dhaduk Jill E Jacobs Anna Shmukler Jeffrey S Berger Germaine Cuff David Rehe Mitchell Lee Robert Donnino Nathaniel R Smilowitz Source Type: research
Cardiovascular Imaging in Contemporary Cardio-Oncology: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 21. doi: 10.1161/CIR.0000000000001174. Online ahead of print.ABSTRACTAdvances in cancer therapeutics have led to dramatic improvements in survival, now inclusive of nearly 20 million patients and rising. However, cardiovascular toxicities associated with specific cancer therapeutics adversely affect the outcomes of patients with cancer. Advances in cardiovascular imaging have solidified the critical role for robust methods for detecting, monitoring, and prognosticating cardiac risk among patients with cancer. However, decentralized evaluations have led to a lack of consensus on the optimal uses of ima...
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Addison Tomas G Neilan Ana Barac Marielle Scherrer-Crosbie Tochi M Okwuosa Juan C Plana Kerryn W Reding Viviany R Taqueti Eric H Yang Vlad G Zaha American Heart Association Council on Cardiovascular Radiology and Intervention; Cardio-Oncology Commi Source Type: research
The importance of baseline fractional flow reserve to detect significant coronary artery stenosis in different patient populations
CONCLUSION: The baseline FFR value could be used to predict critical coronary stenosis in our patients and had similar value for predicting lesion severity in all the subgroups.PMID:37733043 | DOI:10.5830/CVJA-2023-045
Source: Cardiovascular Journal of Africa - September 21, 2023 Category: Cardiology Authors: Ismet Zengin Alper Karakus Source Type: research
