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Specialty: Cardiology
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Total 109613 results found since Jan 2013.
Angiography-based hemodynamic features predict recurrent ischemic events after angioplasty and stenting of intracranial vertebrobasilar atherosclerotic stenosis
CONCLUSIONS: In patients with intracranial vertebrobasilar atherosclerosis treated with PTAS, preprocedural prolonged TTP of the target vessel and shortened trans-stenotic TTP difference were associated with stroke relapse. Q-DSA-defined hemodynamic parameters provided incremental predictive value over conventional parameters for stroke recurrence.CLINICAL RELEVANCE STATEMENT: Quantitative DSA analysis enables intuitive observation and semi-quantitative evaluation of peri-therapeutic cerebral blood flow. More importantly, quantitative DSA-defined hemodynamic parameters have the potential for risk stratification of patients...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Kangmo Huang Weihe Yao Mingming Zha Shanmei Qin Yingle Li Yan Xu Rui Liu Ruidong Ye Yunfei Han Wusheng Zhu Zhongzhao Teng Juan Du Xinfeng Liu Source Type: research
Sex differences in the management of atherosclerotic cardiovascular disease
Atherosclerosis. 2023 Sep 1:117268. doi: 10.1016/j.atherosclerosis.2023.117268. Online ahead of print.ABSTRACTDisparities between women and men persist in the diagnosis, treatment, and prognosis of atherosclerotic cardiovascular disease (ASCVD). Despite growing attention to sex-based differences in cardiovascular care, there are continued disparities in short- and long-term outcomes. Such disparities highlight the need to identify pathophysiologic differences in treatment patterns for stable ischemic heart disease, non-ST elevation myocardial infarction (NSTE-ACS), ST-elevation myocardial infarction (STEMI), and myocardial...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Jessica N Holtzman Gurleen Kaur Breanna Hansen Nalini Bushana Martha Gulati Source Type: research
Coronary and Extracoronary Manifestations of Systemic Inflammatory, Autoimmune, and Connective Tissue Diseases: Pathophysiologic Drivers of Vasculopathy Beyond Atherosclerosis
Am J Cardiol. 2023 Sep 16:S0002-9149(23)00949-9. doi: 10.1016/j.amjcard.2023.08.170. Online ahead of print.NO ABSTRACTPMID:37722970 | DOI:10.1016/j.amjcard.2023.08.170
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Josip A Borovac Chun Shing Kwok Source Type: research
A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan
Biosci Trends. 2023 Sep 17. doi: 10.5582/bst.2023.01221. Online ahead of print.ABSTRACTDiet and circadian rhythms have been found to have a profound impact on health, disease, and aging. Skipping breakfast, eating late, and overeating have adverse effects on the body's metabolism and increase the risk of cardiovascular and metabolic diseases. Disturbance of circadian rhythms has been associated with increased risk of atherosclerosis, Alzheimer's disease, Parkinson's disease, and other diseases. Abnormal deposition of amyloid β (Aβ) and tau proteins in the brain and impaired synaptic function are linked to cognitive dysfu...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiqi Hu Jun Peng Wei Tang Ying Xia Peipei Song Source Type: research
Subacute administration of cilostazol modulates PLC- γ/PKC-α/p38/NF-kB pathway and plays vascular protective effects through eNOS activation in early stages of atherosclerosis development
This study aimed to investigate the effects of subacute administration of cilostazol on the aortas of hypercholesterolemic rats, focusing on the signaling pathways involved in these actions.MAIN METHODS: A murine model of hypercholesterolemia was employed to mimic the early stages of atherosclerosis development. Vascular reactivity assays were performed on thoracic aorta rings to assess the vascular response, as well as the non-invasive blood pressure was evaluated by plethysmography method. Pro-inflammatory markers and malondialdehyde (MDA) levels were measured to investigate the anti-inflammatory and antioxidant effects ...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Stephani Correia Braz ão Gabriel Ferreira Lima Lis Jappour Autran Ana Beatriz Ara újo Mendes Beatriz Alexandre Dos Santos Dangelo Carlo Magliano Fernanda Carla Ferreira de Brito Nadia Alice Vieira Motta Source Type: research
LKB1 delays atherosclerosis by inhibiting phenotypic transformation of vascular smooth muscle cells
CONCLUSION: Our results suggested that LKB1 can delay the progression of atherosclerosis by inhibiting the phenotypic transition of VSMCs.PMID:37722454 | DOI:10.1016/j.ijcard.2023.131363
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Kaicong Chen Chunyan Zhu Qing Zhang Zhihuan Zeng Rong Chen Tudi Li Junqian Luo Zihao Zhou Rui Zeng Source Type: research
Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack
CONCLUSIONS: Elevated TPO-Ab levels may be significantly associated with presence of the RNF213 p. R4810K variant in IS/TIA patients. Thus, TPO-Ab may inherently modify IS/TIA development in RNF213 p. R4810K variant carriers.PMID:37722316 | DOI:10.1016/j.atherosclerosis.2023.117281
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Takeshi Yoshimoto Hiroyuki Ishiyama Yorito Hattori Kunihiro Nishimura Yoko Okada Hideaki Watanabe Yasumasa Ohyagi Yasuhisa Akaiwa Tomoyuki Miyamoto Michi Kawamoto Masahiko Ichijo Hiroyasu Inoue Noriyuki Matsukawa Toshiki Mizuno Hirofumi Matsuyama Hidekazu Source Type: research
Longitudinal lipidomic signature of carotid atherosclerosis in American Indians: Findings from the Strong Heart Family Study
CONCLUSIONS: Baseline and longitudinal changes in multiple lipid species were significantly associated with carotid atherosclerosis and its progression in American Indians. Some plaque-related lipid species were also associated with risk for CVD events.PMID:37722315 | DOI:10.1016/j.atherosclerosis.2023.117265
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Guanhong Miao Oliver Fiehn Mingjing Chen Ying Zhang Jason G Umans Elisa T Lee Barbara V Howard Mary J Roman Richard B Devereux Jinying Zhao Source Type: research
Use of Coronary Artery Calcium Quantification and Distribution for Coronary Vascular Disease Risk Reclassification in a Primary Prevention Setting
In conclusion, the use of MESA-CACS, along with CAC distribution in primary prevention clinics, results in differential and significant reclassification of traditional scores when calculating the 10-years coronary vascular disease risk. Overall, RRS underestimates and ASCVD overestimates the cardiovascular disease risk compared with MESA-CACS.PMID:37722228 | DOI:10.1016/j.amjcard.2023.08.054
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adel Hajj Ali Michael Nakhla Leslie Cho Raul Seballos Richard Lang Steve Feinleib Scott Flamm Paul Schoenhagen Tom Wang Milind Y Desai Source Type: research
Cardiovascular Risk Factors and Culprit Plaque Characteristics in Women With Acute Coronary Syndromes
In conclusion, early treatment of risk factors such as diabetes in young women might be important before accelerated progression of atherosclerosis begins as age advances. Clinical trial registration: http://www.clinicaltrials.gov, NCT01110538, NCT03479723 and NCT02041650.PMID:37722196 | DOI:10.1016/j.amjcard.2023.08.152
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Lena Marie Seegers Doreen DeFaria Yeh Malissa J Wood Taishi Yonetsu Yoshiyasu Minami Makoto Araki Akihiro Nakajima Haruhito Yuki Junya Ako Tsunenari Soeda Osamu Kurihara Takumi Higuma Shigeki Kimura Tom Adriaenssens Holger M Nef Hang Lee Iris McNulty Tomo Source Type: research
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
Angiogenesis inhibitor-specific hypertension increases the risk of developing aortic dissection
Biomed Pharmacother. 2023 Sep 16;167:115504. doi: 10.1016/j.biopha.2023.115504. Online ahead of print.ABSTRACTAortic dissection is an adverse event of angiogenesis inhibitors; however, the association between the drugs and aortic dissection is unclear. Therefore, we investigated if and how angiogenesis inhibitors increase the onset of aortic dissection using pharmacologically-induced aortic dissection-prone model (LAB) mice, cultured endothelial cells, and real-world databases, which is a novel integrated research approach. Disproportionality analysis was performed and calculated using the reporting odds ratio as a risk si...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Kaito Tsujinaka Yuki Izawa-Ishizawa Koji Miyata Toshihiko Yoshioka Kohei Oomine Honoka Nishi Masateru Kondo Syuto Itokazu Tatsumi Miyata Takahiro Niimura Maki Sato Fuka Aizawa Kenta Yagi Masayuki Chuma Yoshito Zamami Mitsuhiro Goda Keisuke Ishizawa Source Type: research
Why Is Religious Attendance Linked to More Anxiety in U.S. South Asians? The Mediating Role of Congregational Neglect
CONCLUSIONS: This study provides evidence that congregational neglect plays an important intervening role in the connection between religious service attendance and anxiety among U.S. South Asians. The findings move beyond description, flagging a relevant social process which underlies the relationship. By recognizing the potential adverse effects of religious attendance on anxiety in this population, it may be possible to develop interventions aimed at enhancing social inclusion in South Asian religious communities. In addition to practical implications, this study highlights the need for further research on how communal ...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Samuel Stroope Blake Victor Kent Anna Boonin Schachter Alka M Kanaya Alexandra E Shields Source Type: research
Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis
CONCLUSION: Our study identified four genes (TYROBP, CSF1R, FCGR1B, and CD14) that may be effective biomarkers for AS, with the potential to guide the clinical diagnosis of AS.PMID:37721628 | DOI:10.1007/s00059-023-05204-3
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Jiajun Ni Kaijian Huang Jialin Xu Qi Lu Chu Chen Source Type: research
Proprotein convertase subtilisin/kexin 9 inhibitor downregulates microRNA-130a-3p expression in hepatocytes to alleviates atherosclerosis progression
This study explores the effect and potential mechanism of PCSK9 inhibitors on lipid metabolism and coronary atherosclerosis. HepG2 cells were incubated with PCSK9 inhibitor. ApoE-/- mice were fed with a high fat to construct an atherosclerosis model, and then treated with PCSK9 inhibitor (8 mg/kg for 8 w). PCSK9 inhibitor downregulated microRNA (miRNA)-130a-3p expression in a dose-dependent manner. And, miR-130a-3p could bind directly to the 3' untranslated region (3'-UTR) region of LDLR to down-regulate LDLR expression in HepG2 cells, as confirmed by the luciferase reporter gene assay. In addition, miR-130a-3p overexpress...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Jinghan Xu Junrong Zuo Chuyi Han Tingting Li Dongxia Jin Fumei Zhao Hongliang Cong Source Type: research
