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Total 109613 results found since Jan 2013.
French National Diagnostic and Care Protocol for antiphospholipid syndrome in adults and children
Rev Med Interne. 2023 Sep 19:S0248-8663(23)00711-7. doi: 10.1016/j.revmed.2023.08.004. Online ahead of print.ABSTRACTAntiphospholipid syndrome (APS) is a chronic autoimmune disease involving vascular thrombosis and/or obstetric morbidity and persistent antibodies to phospholipids or certain phospholipid-associated proteins. It is a rare condition in adults and even rarer in children. The diagnosis of APS can be facilitated by the use of classification criteria based on a combination of clinical and biological features. APS may be rapidly progressive with multiple, often synchronous thromboses, resulting in life-threatening...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Z Amoura B Bader-Meunier C Bal Dit Sollier A Belot Y Benhamou H Bezanahary F Cohen N Costedoat-Chalumeau L Darnige L Drouet E Elefant A Harroche M Lambert T Martin I Martin-Toutain A Mathian A Mekinian M Pineton De Chambrun L de Pontual D Wahl C Yelnik S Source Type: research
Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows
Atherosclerosis. 2023 Sep 19:117272. doi: 10.1016/j.atherosclerosis.2023.117272. Online ahead of print.ABSTRACTA steady rise in cardiovascular morbidity and mortality has been observed in young adults within the last decades. This trend corresponds to an increasing prevalence of traditional cardiovascular risk factors such as obesity and diabetes mellitus type 2 among young adults living in developed countries. Moreover, age-specific risk factors, such as substance abuse, contraceptive medication, and pregnancy-related diseases also correlate with an increased incidence of cardiovascular diseases. In this review, we discus...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Christina Antza Antonio Gallo Chrysoula Boutari Alexandra Ershova Kadri Murat Gurses Joanna Lewek Mirakhmadjon Mirmaksudov G ünther Silbernagel Joakim Sandstedt Anna Lebedeva Source Type: research
Health data ecosystem in Pakistan: a multisectoral qualitative assessment of needs and opportunities
CONCLUSIONS: Our study identified key areas of focus that can contribute to orient a national health data roadmap and ecosystem in Pakistan.PMID:37734897 | DOI:10.1136/bmjopen-2023-071616
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Sana Mahmood Ali Aahil Noorali Afshan Manji Noreen Afzal Saadia Abbas Javeria Bilal Qamar Sameen Siddiqi Zahra Hoodbhoy Salim S Virani Zulfiqar A Bhutta Zainab Samad Source Type: research
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Revising the roles of aldosterone in vascular physiology and pathophysiology: from electocortin to baxdrostat
Can J Cardiol. 2023 Sep 19:S0828-282X(23)01732-4. doi: 10.1016/j.cjca.2023.08.035. Online ahead of print.ABSTRACTAldosterone was initially identified as a hormone primarily related to regulation of fluid and electrolyte homeostasis. However, over the past twenty years there has been an increasing appreciation of its role in regulation of vascular function and pathophysiology in the setting of hypertension, atherosclerosis, and heart failure. The purpose of this review is to highlight recent advances in our understanding the biology of aldosterone as it relates to the pathophysiology and the management of vascular disease-e...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Ross D Feldman Rohan Sanjanwala Raj Padwal Alexander A Leung Source Type: research
Particulate matter air pollution is a significant risk factor for cardiovascular disease
This article discusses PM2.5 effects on the cardiovascular and pulmonary systems, specific PM2.5 pathophysiologic mechanisms contributing to cardiopulmonary disease, and preventive measures to limit the cardiovascular and pulmonary effects of PM2.5.PMID:37734693 | DOI:10.1016/j.cpcardiol.2023.102094
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Robert J Henning Source Type: research
Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis
This study was designed to investigate the effects and underlying mechanisms of linc00657 in atherogenesis. The results showed that ox-LDL treatment significantly induced pyroptosis in human THP-1-derived macrophages. The secretion levels of LDH and pro-inflammatory factors were markedly enhanced, and the integrity of plasma membranes was disrupted in ox-LDL-treated THP-1-derived macrophages. These effects were significantly compensated after transfection with linc00657 siRNA and became more evident by linc00657 overexpression. Moreover, the effects of linc00657 overexpression on pyroptosis of THP-1-derived macrophages can...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Yin Liang Xiao-Dan Xu Xi Xu Yang-Bo Cai Zi-Xian Zhu Lin Zhu Kun Ren Source Type: research
The MEK-ERK-Egr-1 axis and its regulation in cardiovascular disease
This article reviews recent progress on the MEK-ERK-Egr-1 cascade, notably regulation in conjunction with factors and agents such as TET2, TRIB2, MIAT, SphK1, cAMP, teneligliptin, cholinergic drugs, red wine and flavonoids, wogonin, febuxostat, docosahexaenoic acid and AT1R blockade. Such insights should provide new opportunity for therapeutic intervention in CVD.PMID:37734428 | DOI:10.1016/j.vph.2023.107232
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Levon M Khachigian Source Type: research
Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men
Curr Cardiol Rep. 2023 Sep 21. doi: 10.1007/s11886-023-01935-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. RECENT FINDINGS: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients,...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Kelli Blackwell Michele Blackwell Thomas Blackwell Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Development and Characterization of Proteomic Aging Clocks in the Atherosclerosis Risk in Communities (ARIC) Study
We examined their associations with mortality from all-cause, cardiovascular disease (CVD), cancer, and lower respiratory disease (LRD) using Cox proportional hazards regression in all remaining participants irrespective of health. The model was adjusted for chronological age, smoking, body mass index (BMI), and other confounders. The ARIC PACs had a slightly stronger correlation with chronological age than published PACs in healthy participants at each time point. Associations with mortality were similar for the ARIC and published PACs. For late-life and midlife age acceleration for the ARIC PACs, respectively, hazard rat...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Authors Shuo Wang Zexi Rao Rui Cao Anne H Blaes Josef Coresh Corinne E Joshu Benoit Lehallier Pamela L Lutsey James S Pankow Sanaz Sedaghat Weihong Tang Bharat Thyagarajan Keenan A Walker Peter Ganz Elizabeth A Platz Weihua Guan Anna Prizment Source Type: research
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
medRxiv. 2023 Sep 7:2023.09.05.23295093. doi: 10.1101/2023.09.05.23295093. Preprint.ABSTRACTClonal hematopoiesis (CH), characterized by blood cells predominantly originating from a single mutated hematopoietic stem cell, is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD). While CH is common among older adults, the underlying factors driving its development are largely unknown. To address this, we performed whole-exome sequencing on 8,374 blood DNA samples collected from 4,187 Atherosclerosis Risk in Communities Study (ARIC) participants over a me...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Md Mesbah Uddin Seyedmohammad Saadatagah Abhishek Niroula Bing Yu Whitney Hornsby Shriienidhie Ganesh Kim Lannery Art Shuermans Michael C Honigberg Alexander G Bick Peter Libby Benjamin L Ebert Christie M Ballantyne Pradeep Natarajan Source Type: research
Cardiac microRNAs: diagnostic and therapeutic potential
Arch Med Sci. 2023 Aug 25;19(5):1360-1381. doi: 10.5114/aoms/169775. eCollection 2023.ABSTRACTMicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. In cardiovascular disease pathophysiology, there are several cells that produce microRNAs, including endothelial cells, vascular smooth muscle cells, macrophages, platelets, and cardiomyocytes. There is a constant crosstalk between microRNAs derived from variou...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Anna Kab łak-Ziembicka Rafa ł Badacz Micha ł Okarski Magdalena Wawak Tadeusz Przew łocki Jakub Podolec Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Smoking, immunity, and cardiovascular prognosis: a study of plasma IgE concentration in patients with acute myocardial infarction
CONCLUSION: Cotinine exhibits a positive association with AMI, wherein IgE plays a mediating role. Elevated plasma levels of IgE was positively associated with AMI and poor prognosis, which further confirms the adverse role of smoking on the incidence of AMI and prognosis. (Clinical trial registration: ChiCTR2100053000).PMID:37731521 | PMC:PMC10508960 | DOI:10.3389/fcvm.2023.1174081
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Lili Zhang Yanrong Zhu Xin Meng Yifan Zhang Qian Ren Dong Huang Zhong Chen Source Type: research
