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Specialty: Cardiology
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Total 109613 results found since Jan 2013.
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis
CONCLUSION: These findings established a novel strategy for targeting the NLRP3 inflammasome using NLRP3 siRNA-PCLs to interrupt LDL transcytosis, representing a potential novel therapy for atherosclerosis.PMID:35917895 | DOI:10.1016/j.metabol.2022.155274
Source: Atherosclerosis - August 2, 2022 Category: Cardiology Authors: Xiong Jia Xiangli Bai Xiaoyan Yang Ling Wang Yajing Lu Lin Zhu Ying Zhao Wenzhuo Cheng Meng Shu Qiyong Mei Si Jin Source Type: research
Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages
Nat Protoc. 2022 Feb 4. doi: 10.1038/s41596-021-00665-4. Online ahead of print.ABSTRACTMacrophages in atherosclerotic lesions promote plaque progression and are an attractive therapeutic target in cardiovascular research. Here we present a protocol for synthesis of small interfering RNA (siRNA) nanoparticles (NP) that target lesional macrophages as a potential treatment for atherosclerosis. Ca2+/calmodulin-dependent protein kinase γ (CaMKIIγ) activity in macrophages of advanced human and mouse atherosclerotic plaques drives necrosis by downregulating the expression of the efferocytosis receptor MerTK. Therefore, selectiv...
Source: Atherosclerosis - February 5, 2022 Category: Cardiology Authors: Xiangang Huang Chuang Liu Na Kong Yufen Xiao Arif Yurdagul Ira Tabas Wei Tao Source Type: research
Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
In conclusion, we successfully constructed Ndufs4 siRNA recombinant adenovirus; furthermore, the downexpression of the Ndufs4 gene may alleviate H2O2-induced H9c2 cell apoptosis.PMID:36741296 | PMC:PMC9897913 | DOI:10.1155/2023/8141129
Source: Cardiology Research and Practice - February 6, 2023 Category: Cardiology Authors: Beibei Wang Jinsheng Zhang Aijun Xu Source Type: research
Estrogen Receptor-{beta} in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats Estrogen
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women. Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional specificity of different ER subtypes in the protective actions of estrogen in aldosterone (Aldo)-induced hyperten...
Source: Hypertension - May 15, 2013 Category: Cardiology Authors: Xue, B., Zhang, Z., Beltz, T. G., Johnson, R. F., Guo, F., Hay, M., Johnson, A. K. Tags: Animal models of human disease, Other hypertension Estrogen Source Type: research
Abstract P310: Atuplex Formulated With Small Interfering RNA For Soluble Fms-like Tyrosine Kinase-1 (sFLT1) Selectively Silences Maternal And Placental sFLT1 In A Preeclamptic Rat Model Session Title: Pregnancy and Preeclampsia and Developmental Programming of Cardiovascular Disease
Preeclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, affecting about 5-8% of pregnancies. It is a major cause of fetal and maternal morbidity/mortality. The disease is most probably multifactorial and caused by several placental dysfunctions. As an important mediator, sFLT1 is induced in the placenta and in the serum of preeclamptic women, acting as a decoy receptor for placenta like growth factors (PLGF) and inducing an antiangiogenic balance. RNAi mediated gene specific silencing could represent a new therapeutic option in preeclampsia management. We tested sFLT1-specific small inte...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Nadine Haase, Kristin Kraker, Ute Schaeper, Jens Endruschat, Dominik N Muller, Ralf Dechend Tags: Poster Abstract Presentations Source Type: research
Anti-HB-EGF Antibody-Mediated Delivery of siRNA to Atherosclerotic Lesions in Mice.
Authors: Tsuchida S, Matsuzaki T, Yamato M, Okuda K, Fu HY, Araki R, Sanada S, Asanuma H, Asano Y, Asakura M, Hao H, Takashima S, Kitakaze M, Sakata Y, Mekada E, Minamino T
Abstract
For atherosclerotic cardiovascular diseases (ACD), gene therapy may be a potential therapeutic strategy; however, lack of effective and safe methods for gene delivery to atherosclerotic plaques have limited its potential therapeutic applications. To overcome this limitation, we developed a novel antibody-based gene delivery system (anti-HB-EGF/NA vector) by chemically crosslinking antibodies against human heparin-binding epidermal growt...
Source: International Heart Journal - November 7, 2018 Category: Cardiology Tags: Int Heart J Source Type: research
Abstract 154: Knockdown of Mineralocorticoid or AT1 Receptor Gene in the Paraventricular Nucleus Prevents Ang II Induced Hypertension in Rats Poster Session I
Circulating Ang II activates an aldosterone-MR-AT1R pathway in the hypothalamus. To obtain insights into the actual aldosterone-MR- AT1R neuronal pathway, the present study examined whether intra-PVN infusion of AAV-AT1aR-siRNA or AAV-MR-siRNA prevents the Ang II induced increases in AT1R and MR expression and BP. Two weeks sc infusion of Ang II at 500ng/kg/min in Wistar rats on regular salt diet increased BP by telemetry by 66 ± 3 mm Hg, and AT1R and MR protein in the SFO, SON and PVN. Intra-PVN AT1aR-siRNA decreased AT1R but not MR expression in the PVN by sc Ang II, and MR-siRNA decreased MR but not AT1R expressi...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Chen, A., Huang, B. S., Wang, H., Ahmad, M., Leenen, F. H. Tags: Poster Session I Source Type: research
Serum amyloid A and interleukin -1 β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway
CONCLUSIONS: SAA and IL-1β accelerated LDL transcytosis via the NF-κB/caveolin-1/cavin-1 axis.PMID:36935311 | DOI:10.1016/j.atherosclerosis.2023.03.004
Source: Atherosclerosis - March 19, 2023 Category: Cardiology Authors: Xiong Jia Zongtao Liu Yixuan Wang Geng Li Xiangli Bai Source Type: research
