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Total 89913 results found since Jan 2013.

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Clinical Cancer Research - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Correction: Liver Transplantation After Hepatic Artery Infusion Pump Therapy: Single-Center Experience and Technical Considerations
Ann Surg Oncol. 2023 Sep 22. doi: 10.1245/s10434-023-14351-0. Online ahead of print.NO ABSTRACTPMID:37737969 | DOI:10.1245/s10434-023-14351-0
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Angela L Hill Darren R Cullinan Ola Ahmed Neeta Vachharajani Meranda D Scherer Franklin Olumba Adeel S Khan William C Chapman Majella B Doyle Source Type: research

EGR1 Promotes Ovarian Hyperstimulation Syndrome Through Upregulation of SOX9 Expression
This study aimed to investigate the function and mechanism of EGR1 involved in OHSS progression. RNA-sequencing was used to identify differentially expressed genes. In vitro OHSS cell model was induced by treating KGN cells with human chorionic gonadotropin (hCG). In vivo OHSS model was established in mice. The expression levels of EGR1, SOX1, and VEGF were determined by Quantitative Real-Time polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence staining, and immunochemistry assay. The content of VEGF in the culture medium of human granulosa-like tumor cell line (KGN) cells was accessed by the ELISA assay....
Source: Cell Transplantation - September 22, 2023 Category: Cytology Authors: Huihui Wang Weijia Chen Yinan Huang Yuan Sun Yuanhua Liu Yuanchao Zhu Zongxuan Lu Source Type: research

Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4  + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research

Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research

Building the Evidence for Exercise in Solid Organ Transplant: How Far Have We Moved the Needle?
Physiother Can. 2023 Sep 19;75(3):209-211. doi: 10.3138/ptc-2022-0111. eCollection 2023 Sep.NO ABSTRACTPMID:37736416 | PMC:PMC10510535 | DOI:10.3138/ptc-2022-0111
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

La collecte de donn ées probantes sur l’exercice en cas de transplantation d’organe plein : à quel point avons-nous progressé?
Physiother Can. 2023 Sep 19;75(3):212-214. doi: 10.3138/ptc-2022-0111-fr. eCollection 2023 Sep.NO ABSTRACTPMID:37736412 | PMC:PMC10510543 | DOI:10.3138/ptc-2022-0111-fr
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research

Is cervical dysplasia a major concern in women with inflammatory bowel disease? A Spanish retrospective study
Rev Esp Enferm Dig. 2023 Sep 21. doi: 10.17235/reed.2023.9890/2023. Online ahead of print.ABSTRACTCervical cancer (CC) is the fourth most common cancer affecting women worldwide. The risk of women immunosuppressed due to AIDS or organ transplantation is well documented, as most cases are caused by persistent human papillomavirus (HPV) infection and immunosuppression can prevent clearing HPV. Although European guidelines advise that inflammatory bowel disease (IBD) women under immunosuppression should be screened for CC as regularly as high-risk patients, quality evidence is lacking in our country. We performed a retrospect...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Lorena Jara Fern ández Juan Ángel Ferrer Jos é Lázaro Pérez Calle Pilar L ópez Serrano Source Type: research

CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research

Outcome heterogeneity of < em > TP53 < /em > -mutated myeloid neoplasms and the role of allogeneic hematopoietic cell transplantation
Haematologica. 2023 Sep 21. doi: 10.3324/haematol.2023.283886. Online ahead of print.ABSTRACTNot available.PMID:37731390 | DOI:10.3324/haematol.2023.283886
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Sergiu Pasca Saurav D Haldar Alexander Ambinder Jonathan A Webster Tania Jain W Brian Dalton Gabrielle T Prince Gabriel Ghiaur Amy E DeZern Ivana Gojo B Douglas Smith Theodoros Karantanos Cory Schulz Kristin Stokvis Mark J Levis Richard J Jones Lukasz P G Source Type: research

Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research

Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Ann Biomed Eng. 2023 Sep 20. doi: 10.1007/s10439-023-03370-3. Online ahead of print.ABSTRACTTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine. In this review, we first summarize different harvesting procedures and advantages of cell sheet techn...
Source: Annals of Biomedical Engineering - September 21, 2023 Category: Biomedical Engineering Authors: Yexin Li Ting Deng Dilihumaer Aili Yang Chen Weihong Zhu Qian Liu Source Type: research

Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury
World J Gastroenterol. 2023 Sep 7;29(33):4927-4941. doi: 10.3748/wjg.v29.i33.4927.ABSTRACTHepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver transplantation, that may increase the postoperative morbidity, mortality, tumor progression, and metastasis. The underlying mechanisms have been extensively investigated in recent years. Among these, oxidative stress, inflammatory responses, immunoreactions, and cell death are the most studied. Non-coding RNAs (ncRNAs) are defined as the RNAs that do not encode proteins, but can regulate gene expressions. In recent years, ncRNAs have emerg...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Jia-Li Shao Li-Juan Wang Ji Xiao Jin-Feng Yang Source Type: research

Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.ABSTRACTHepatitis due to hepatitis B virus (HBV) reactivation can be serious and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving chemotherapy, especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation. Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver. The expression of these silent genomes is controlled by the immune system. Suppression or ablation of immune cells, most imp...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Source Type: research