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Contribution of non-socioeconomic factors to healthy quality of life in socioeconomically deprived patients with advanced gastrointestinal cancer: Measuring attributable fraction
CONCLUSIONS: Gait, self-care ability, abdominal distension, nutritional status, weight loss and posture are important determinants of healthy quality of life in patients with advanced gastrointestinal cancer with socioeconomic deprivation, and early identification and strength management of these non-socioeconomic factors may neutralize the negative impact of socioeconomic factors on the quality of life.IMPLICATIONS FOR PRACTICE: This study provides new ideas and intervention entry points for global nurses in practice innovations to improve the quality of life of socioeconomically deprived patients with advanced gastrointe...
Source: Adv Data - September 15, 2023 Category: Epidemiology Authors: Zifen An Jiaqi Nie Yanfang Huang Pei Fang Xianmei Meng Chunfeng Cai Liping Yu Source Type: research
Malignancy-associated membranous nephropathy: focus on diagnosis and treatment
CONCLUSIONS: Tumor screening is important in patients with membranous nephropathy, especially in elderly patients and patients with negative phospholipase A2 receptor or non-IgG4 predominant deposition. Remission of membranous nephropathy can be observed following remission of cancer in some cases. Immunosuppressive therapy may be considered if membranous nephropathy does not remit after remission of cancer.PMID:37713160 | DOI:10.1007/s40620-023-01751-4
Source: Journal of Nephrology - September 15, 2023 Category: Urology & Nephrology Authors: SanXi Ai XiWei Yan XueSong Zhao WenLing Ye YuBing Wen Jing Wang BoJu Pan Jie Dong XueMei Li Yan Qin Source Type: research
Diminished criminal responsibility: A multinational comparative review
This article reviews the legal frameworks of diminished criminal responsibility in eighteen civil law jurisdictions across the globe-Brazil, Chile, China, the Czech Republic, Finland, France, Germany, Greece, Italy, Japan, Luxembourg, Poland, Portugal, Russia, Spain, Switzerland, Taiwan, and Turkey. Specifically, it reports the legal standards and main features of partial responsibility, associated penalty reductions, and potential dispositions following a partial responsibility finding. It also surveys empirical data on the prevalence of diminished responsibility as compared to criminal nonresponsibility. This article, wh...
Source: International Journal of Law and Psychiatry - September 15, 2023 Category: Medical Law Authors: E Lea Johnston Kendall D Runyan Fernando Jos é Silva Francisco Maldonado Fuentes Source Type: research
Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study
CONCLUSION: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to identifying individuals at risk of all-cause dementia.PMID:37711110 | DOI:10.2174/1567205020666230914161034
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Bin Zhou Qianhua Zhao Shinsuke Kojima Ding Ding Satoshi Higashide Masanori Fukushima Zhen Hong Source Type: research
Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages
Biochem Pharmacol. 2023 Sep 13:115806. doi: 10.1016/j.bcp.2023.115806. Online ahead of print.ABSTRACTSepsis is a dysregulated systemic inflammatory response caused by infection that leads to multiple organ injury and high mortality without effective treatment. Corilagin, a natural polyphenol extracted from traditional Chinese herbs, exhibits strong anti-inflammatory properties. However, the role for Corilagin in lipopolysaccharide (LPS)-induced sepsis and the molecular mechanisms underlying this process have not been completely explored. Here we determine the effect of Corilagin on LPS-treated mice and use a screening appr...
Source: Biochemical Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Senquan Wu Jia Liao Guodong Hu Liang Yan Xingyu Su Jiezhou Ye Chanjuan Zhang Tian Tian Huadong Wang Yiyang Wang Source Type: research
Analysis of the mechanism of action of Euphorbia fischeriana Steud on cirrhosis based on network pharmacology
This study aimed to employ network pharmacology to elucidate the mechanism by which Euphorbia fischeriana Steud (EFS) exhibits the efficacy on cirrhosis. The compounds and targets of EFS were retrieved from Traditional Chinese Medicine Integrated Database and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Next, these compounds and targets were analyzed based on protein-protein interaction (PPI) network. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling network was established based on KEGG database. We constructed a compound-compound target-intersection target-...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Lu Liu Yinliang Xu Liu Yang Zhenzhong Jiang Xiaoyan Li Source Type: research
Network pharmacology and molecular docking to explore the mechanism of Sheng Xue Bao mixture against iron deficiency anemia
Medicine (Baltimore). 2023 Sep 15;102(37):e35012. doi: 10.1097/MD.0000000000035012.ABSTRACTBased on network pharmacology and molecular docking, we investigated the mechanism of action of Sheng Xue Bao mixture (SXBM) in treating iron deficiency anemia (IDA). We screened the HERB and traditional Chinese medicine systems pharmacology database and analysis platform databases to identify the active ingredients and targets of SXBM. The targets associated with "iron deficiency anemia" were collected from GeneCards, TTD, and OMIM databases. A component-target interaction network was constructed using Cytoscape 3.8.2. The protein-p...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Yun Wang Huang Qinqin Haixia Wang Hongxu Zhang Xinhua Zhang Weiguo Liu Zhenhua Xiang Yuming Gu Source Type: research
Effect of dominant vertebral artery angle on basilar artery curvature and plaque
CONCLUSIONS: The dominant VA angle was independently associated with BA plaque, and a dominant VA angle greater than 80° may be a marker for a high risk of posterior circulation atherosclerosis.PMID:37711832 | PMC:PMC10498226 | DOI:10.21037/qims-23-74
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Yangchen Li Runcai Guo Xuebing Zhang Yang Yang Yuchun Yan Xinyu Yuan Ce Wang Sheng Xie Source Type: research
Correlation between High Incidence of Colorectal Neoplastic Polyps and High-risk Adenomas in Patients with Diabetes Mellitus: A Retrospective Study
CONCLUSION: This study demonstrated that patients with DM, age ≥ 50 years, male gender, alcohol consumption, and a first-degree relative with a history of CRC should undergo regular endoscopic screening and colonic polypectomy.PMID:37711116 | DOI:10.2174/1871530323666230913105743
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Chuan-Yu Zheng Wa Zhong Ji-Hao Xu Yu-Hong Yuan Nai-Zhao Chen Wei-Ling Liang Qi-Kui Chen Yu Lai Source Type: research
2023 Chinese guideline for lipid management
Front Pharmacol. 2023 Aug 29;14:1190934. doi: 10.3389/fphar.2023.1190934. eCollection 2023.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of death among urban and rural residents in China, and elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for ASCVD. Considering the increasing burden of ASCVD, lipid management is of the utmost importance. In recent years, research on blood lipids has made breakthroughs around the world, hence a revision of Chinese guideline for lipid management is imperative, especially since the target lipid levels in the general population vary in respe...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Jian-Jun Li Shui-Ping Zhao Dong Zhao Guo-Ping Lu Dao-Quan Peng Jing Liu Zhen-Yue Chen Yuan-Lin Guo Na-Qiong Wu Sheng-Kai Yan Zeng-Wu Wang Run-Lin Gao Source Type: research
Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
This article summarizes the pharmacological effects, pharmacokinetic characteristics, and toxicity of luteolin against liver diseases, and provides prospect. The results indicate that luteolin improves liver lesions through various mechanisms, including inhibiting inflammatory factors, reducing oxidative stress, regulating lipid balance, slowing down excessive aggregation of extracellular matrix, inducing apoptosis and autophagy of liver cancer cells. Pharmacokinetics research manifested that due to metabolic effects, the bioavailability of luteolin is relatively low. It is worth noting that appropriate modification, new d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Chenhao Yao Shu Dai Cheng Wang Ke Fu Rui Wu Xingtao Zhao Yuxin Yao Yunxia Li Source Type: research
Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway
CONCLUSION: Microglial M1/M2 polarization plays a pivotal role in inflammation and ferroptosis during OGD/R. The BMP6/SMADs signaling pathway is a potential therapeutical target of inflammation and ferroptosis induced by the transformation of microglia. Moreover, NTF could alleviate inflammation and ferroptosis through the BMP6/SMADs signaling pathway in OGD/R-injured microglia.PMID:37713988 | DOI:10.1016/j.biopha.2023.115465
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Jun Liao Mengzhen Wei Jianjun Wang Jinsong Zeng Danhong Liu Qiusi Du Jinwen Ge Zhigang Mei Source Type: research
Estimating the geographical patterns and health risks associated with PM < sub > 2.5 < /sub > -bound heavy metals to guide PM < sub > 2.5 < /sub > control targets in China based on machine-learning algorithms
In this study, we compiled a substantial dataset consisting of the concentrations of eight PBHMs, including As, Cd, Cr, Cu, Mn, Ni, Pb and Zn, across different cities in China. To improve prediction accuracy, we enhanced the traditional land-use regression (LUR) model by incorporating emission source-related variables and employing the best-fitted machine-learning algorithm, which was applied to predict PBHM concentrations, analyze geographical patterns and assess the health risks associated with metals under different PM2.5 control targets. Our model exhibited excellent performance in predicting the concentrations of PBHM...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Tong Lyu Yilin Tang Hongbin Cao Yue Gao Xu Zhou Wei Zhang Ruidi Zhang Yanxue Jiang Source Type: research
Clinical Characterization and Molecular Analysis of Fourteen Chinese Patients with Factor V Deficiency
CONCLUSION: This is the largest genetic analysis of a single cohort of FV deficiency in Chinese. The study demonstrated that FV levels tended to be correlated with the probability of hemorrhage. The identification of a large number of unique FV-deficient pedigrees highlighted the screening for mutations in F5.PMID:37714176 | DOI:10.1055/a-2146-9540
Source: Hamostaseologie - September 15, 2023 Category: Hematology Authors: Ke Zhang Longying Ye Yanhui Jin Yuan Chen Manlin Zeng Kaiqi Jia Lihong Yang Mingshan Wang Source Type: research
A web-based prediction model for long-term cancer-specific survival of middle-aged patients with early-stage gastric cancer: a multi-institutional retrospective study
CONCLUSION: This study developed and validated a new nomogram to predict CSS in middle-aged patients with EGC. The prediction model has unique and practical value and can help doctors carry out individualized treatment and judge prognosis.PMID:37712958 | DOI:10.1007/s00432-023-05405-7
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Simeng Zhang Longbo Zheng Yuxia Zhang Yuan Gao Lei Liu Zinian Jiang Liang Wang Zheng Ma Jinhui Wu Jiansheng Chen Yun Lu Dongsheng Wang Source Type: research
