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Recombinant Antibodies to Face SARS-CoV-2 Syndemic
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):24-27. doi: 10.14715/cmb/2023.69.7.4.ABSTRACTIn recent years, increasing interest has been paid to using antibody-based therapies for clinical applications. However, it is unclear whether recombinant antibodies can be combined with other scientific approaches to generate innovative solutions for mitigating severe acute respiratory syndrome coronavirus 2. In this context, the increase in this virus transmission, the number of infected people, and the interaction between social and biological processes have led to a syndemic, exacerbating the public health problem. Here, we a...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maykel Gonz ález Torres Gerardo Leyva G ómez Mar ía Luisa Del Prado-Audelo Hern án Cortés Jonathan J Maga ña Source Type: research
Examining the Influence of Imbalanced Social Contact Matrices in Epidemic Models
Am J Epidemiol. 2023 Sep 15:kwad185. doi: 10.1093/aje/kwad185. Online ahead of print.ABSTRACTTransmissible infections such as those caused by SARS-CoV-2 spread according to who contacts whom. Therefore, many epidemic models incorporate contact patterns through contact matrices. Contact matrices can be generated from social contact survey data. However, the resulting matrices are often imbalanced, such that the total number of contacts reported by group A with group B do not match those reported by group B with group A. We examine the theoretical influence of imbalanced contact matrices on the estimated basic reproduction n...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Mackenzie Hamilton Jesse Knight Sharmistha Mishra Source Type: research
COVID-19 vaccine effectiveness against hospitalizations in Paraguay, May 2021-April 2022: A test-negative design
CONCLUSIONS: This study contributes to our understanding of COVID-19 VE in Latin America and to global understanding of vaccines that have not been widely used in North America and Europe. VE estimates from Paraguay can parameterize models to estimate the impact of the national COVID-19 vaccination campaign in Paraguay and similar settings.PMID:37716830 | DOI:10.1016/j.vaccine.2023.09.015
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Sandra Irala Sarah Hamid Elena Penayo Fabiana Michel Paula Couto Cynthia Vazquez Mar ía José Ortega Chavely Dom ínguez Silvia Battaglia Marta Von Horoch Romeo Montoya Guillermo Sequera Francisco Nogareda Source Type: research
Examining the Influence of Imbalanced Social Contact Matrices in Epidemic Models
Am J Epidemiol. 2023 Sep 15:kwad185. doi: 10.1093/aje/kwad185. Online ahead of print.ABSTRACTTransmissible infections such as those caused by SARS-CoV-2 spread according to who contacts whom. Therefore, many epidemic models incorporate contact patterns through contact matrices. Contact matrices can be generated from social contact survey data. However, the resulting matrices are often imbalanced, such that the total number of contacts reported by group A with group B do not match those reported by group B with group A. We examine the theoretical influence of imbalanced contact matrices on the estimated basic reproduction n...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Mackenzie Hamilton Jesse Knight Sharmistha Mishra Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
A synthetic delivery vector for mucosal vaccination
Biomaterials. 2023 Sep 5;302:122298. doi: 10.1016/j.biomaterials.2023.122298. Online ahead of print.ABSTRACTThe success of mRNA-based vaccines during the Covid-19 pandemic has highlighted the value of this new platform for vaccine development against infectious disease. However, the CD8+ T cell response remains modest with mRNA vaccines, and these do not induce mucosal immunity, which would be needed to prevent viral spread in the healthy population. To address this drawback, we developed a dendritic cell targeting mucosal vaccination vector, the homopentameric STxB. Here, we describe the highly efficient chemical synthesi...
Source: Biomaterials - September 15, 2023 Category: Materials Science Authors: Anne Billet Justine Hadjerci Thi Tran Pascal Kessler Jonathan Ulmer Gilles Mourier Marine Ghazarian Anthony Gonzalez Robert Thai Pauline Urquia Anne-C écile Van Baelen Annalisa Meola Ignacio Fernandez St éphanie Deville-Foillard Ewan MacDonald L éa Pao Source Type: research
High-density Au nanoshells assembled onto Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoclusters for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein
Biosens Bioelectron. 2023 Sep 10;241:115688. doi: 10.1016/j.bios.2023.115688. Online ahead of print.ABSTRACTTraditional lateral flow immunoassays (LFIA) suffer from insufficient sensitivity, difficulty for quantitation, and susceptibility to complex substrates, limiting their practical application. Herein, we developed a polyethylenimine (PEI)-mediated approach for assembling high-density Au nanoshells onto Fe3O4 nanoclusters (MagAushell) as LFIA labels for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein (N protein). PEI layer served not only as "binders" to Fe3O4 ...
Source: Biosensors and Bioelectronics - September 15, 2023 Category: Biotechnology Authors: Xiang Li Dong Yu Huiwen Li Ruichang Sun Zhuoran Zhang Tianyu Zhao Gengchen Guo Jingbin Zeng Cong-Ying Wen Source Type: research
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
High-density Au nanoshells assembled onto Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoclusters for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein
Biosens Bioelectron. 2023 Sep 10;241:115688. doi: 10.1016/j.bios.2023.115688. Online ahead of print.ABSTRACTTraditional lateral flow immunoassays (LFIA) suffer from insufficient sensitivity, difficulty for quantitation, and susceptibility to complex substrates, limiting their practical application. Herein, we developed a polyethylenimine (PEI)-mediated approach for assembling high-density Au nanoshells onto Fe3O4 nanoclusters (MagAushell) as LFIA labels for integrated enrichment and photothermal/colorimetric dual-mode detection of SARS-CoV-2 nucleocapsid protein (N protein). PEI layer served not only as "binders" to Fe3O4 ...
Source: Biosensors and Bioelectronics - September 15, 2023 Category: Biotechnology Authors: Xiang Li Dong Yu Huiwen Li Ruichang Sun Zhuoran Zhang Tianyu Zhao Gengchen Guo Jingbin Zeng Cong-Ying Wen Source Type: research
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
