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Total 80815 results found since Jan 2013.
Post-Acute Sequelae of SARS-CoV-2: More Than Deconditioning
Chest. 2023 Sep;164(3):583-584. doi: 10.1016/j.chest.2023.03.014.NO ABSTRACTPMID:37689472 | DOI:10.1016/j.chest.2023.03.014
Source: Chest - September 9, 2023 Category: Respiratory Medicine Authors: Phillip Joseph Inderjit Singh Source Type: research
TWiV 1042: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with C...
Source: This Week in Virology - MP3 Edition - September 9, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
The impact of the early COVID-19 pandemic on healthcare system resource use and costs in two provinces in Canada: An interrupted time series analysis
CONCLUSIONS: Reduced utilization of healthcare services in the overall population outweighed utilization by COVID-19 patients in 2020. Meeting the needs of all patients across all services is essential to maintain resilient healthcare systems.PMID:37682823 | DOI:10.1371/journal.pone.0290646
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Seraphine Zeitouny Douglas C Cheung Karen E Bremner Reka E Pataky Priscila Pequeno John Matelski Stuart Peacock M Elisabeth Del Giudice Lauren Lapointe-Shaw George Tomlinson Andrew B Mendlowitz Carol Mulder Teresa C O Tsui Nathan Perlis Jennifer D Walker Source Type: research
The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research
USE OF RECOMBINANT S1 PROTEIN WITH hFc FOR ANALYSIS OF SARS-COV-2 ADSORPTION AND EVALUATION OF DRUGS THAT INHIBIT ENTRY INTO VERO E6 CELLS
Immunol Lett. 2023 Sep 6:S0165-2478(23)00145-1. doi: 10.1016/j.imlet.2023.09.002. Online ahead of print.ABSTRACTThe significant number of deaths and cases of infection by the new coronavirus SARS-CoV-2 requires an urgent demand for effective and available drugs for the treatment of COVID-19.However, the need for biosafety level 3 (NB-3) laboratories for experiments with the virus has made it very difficult for such research to meet this demand. It is known that angiotensin-converting enzyme 2 (ACE2), located on the surface of host cells, is the viral receptor for the spike (S) protein of SARS-CoV-2. This protein is a tetra...
Source: Immunology Letters - September 8, 2023 Category: Allergy & Immunology Authors: J éssica Carla Martins Couto Ta Ãs Vidal Eduardo Reichert Decker Janio M Santurio Carlos Fernando de Mello Micheli Mainardi Pillat Source Type: research
Optimisation of SARS-CoV-2 peptide stimulation and measurement of cytokine output by intracellular flow cytometry and bio-Plex analysis
J Immunol Methods. 2023 Sep 6:113556. doi: 10.1016/j.jim.2023.113556. Online ahead of print.ABSTRACTOur study was conducted to optimise a peptide stimulation and an intracellular cytokine staining protocol, alongside Bio-Plex supernatant analysis, for use in patients who had previously contracted SARS-CoV-2 or received vaccination against this virus in a clinical laboratory setting. Peripheral Blood Mononuclear Cell extraction and cryopreservation allowed for cells to be stored long term and enhanced logistical processing of samples. Viability and functionality of cells were analysed by flow cytometric methodology using vi...
Source: Journal of Immunological Methods - September 8, 2023 Category: Allergy & Immunology Authors: Jemma Victoria Taylor Emma Louise Callery Anthony Rowbottom Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses
Conclusions: It was demonstrated that CBD inhibits structurally dissimilar viruses, suggesting that this phytochemical has broad-spectrum antiviral effect, representing a valuable alternative in emergency situations during viral outbreaks, like the one caused by severe acute respiratory syndrome coronavirus 2 in 2020.PMID:37682578 | DOI:10.1089/can.2023.0103
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Agostina B Marquez Josefina Vicente Eliana Castro Daiana Vota Mar Ãa S RodrÃguez-Varela Priscila A Lanza Castronuovo Giselle M Fuentes Alejandro R Parise Leonardo Romorini Diego E Alvarez Carlos A Bueno Cristina L Ramirez Agustina Alaimo Cybele C Garc à Source Type: research
USE OF RECOMBINANT S1 PROTEIN WITH hFc FOR ANALYSIS OF SARS-COV-2 ADSORPTION AND EVALUATION OF DRUGS THAT INHIBIT ENTRY INTO VERO E6 CELLS
Immunol Lett. 2023 Sep 6:S0165-2478(23)00145-1. doi: 10.1016/j.imlet.2023.09.002. Online ahead of print.ABSTRACTThe significant number of deaths and cases of infection by the new coronavirus SARS-CoV-2 requires an urgent demand for effective and available drugs for the treatment of COVID-19.However, the need for biosafety level 3 (NB-3) laboratories for experiments with the virus has made it very difficult for such research to meet this demand. It is known that angiotensin-converting enzyme 2 (ACE2), located on the surface of host cells, is the viral receptor for the spike (S) protein of SARS-CoV-2. This protein is a tetra...
Source: Immunology Letters - September 8, 2023 Category: Allergy & Immunology Authors: J éssica Carla Martins Couto Ta Ãs Vidal Eduardo Reichert Decker Janio M Santurio Carlos Fernando de Mello Micheli Mainardi Pillat Source Type: research
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses
Conclusions: It was demonstrated that CBD inhibits structurally dissimilar viruses, suggesting that this phytochemical has broad-spectrum antiviral effect, representing a valuable alternative in emergency situations during viral outbreaks, like the one caused by severe acute respiratory syndrome coronavirus 2 in 2020.PMID:37682578 | DOI:10.1089/can.2023.0103
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Agostina B Marquez Josefina Vicente Eliana Castro Daiana Vota Mar Ãa S RodrÃguez-Varela Priscila A Lanza Castronuovo Giselle M Fuentes Alejandro R Parise Leonardo Romorini Diego E Alvarez Carlos A Bueno Cristina L Ramirez Agustina Alaimo Cybele C Garc à Source Type: research
Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease
In this report, we identified [1,2]selenazolo[5,4-c]pyridin-3(2H)-one and benzo[d]isothiazol-3(2H)-one as attractive scaffolds of PLpro and Mpro inhibitors. The representative compounds 6c and 7e exhibited excellent PLpro inhibition with percent inhibition of 42.9% and 44.9% at 50 nM, respectively. The preliminary enzyme kinetics experiment and fluorescent labelling experiment results determined that 6c was identified as a covalent PLpro inhibitor, while 7e was a non-covalent inhibitor. Molecular docking and dynamics simulations revealed that 6c and 7e bound to Zn-finger domain of PLpro. Compounds 6c and 7e were also ident...
Source: Bioorganic Chemistry - September 8, 2023 Category: Chemistry Authors: Wandong Liu Juan Wang Suyun Wang Kairui Yue Yu Hu Xiaochun Liu Lihao Wang Shengbiao Wan Ximing Xu Source Type: research
The Power of Molecular Dynamics Simulations and Their Applications to Discover Cysteine Protease Inhibitors
Mini Rev Med Chem. 2023 Sep 1. doi: 10.2174/1389557523666230901152257. Online ahead of print.ABSTRACTA large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved. CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papain-like endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues of His, Glu/Asp, Gln, Cys (CE). The cata...
Source: Mini Reviews in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Joilly Nilce Santana Gomes J éssika de Oliveira Viana Yvnni Maria Sales de Medeiros E Silva Euz ébio Guimarães Barbosa Ricardo Olimpio de Moura Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
