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Total 3990 results found since Jan 2013.

Crystal arthropathies and osteoarthritis —where is the link?
AbstractOsteoarthritis (OA) is one of the leading causes of disability worldwide. As our understanding of OA progressively has moved from a purely mechanical “wear and tear” concept toward a complex multi-tissue condition in which inflammation plays a central role, the possible role of crystal-induced inflammation in OA incidence and progression may be relevant. In addition to gout, which affects 4% of the US population, basic calcium phosphate and c alcium pyrophosphate deposition both may induce joint inflammation and may play a role in pain in OA. This narrative review article discusses the possible mechanisms under...
Source: Skeletal Radiology - September 20, 2023 Category: Radiology Source Type: research

A 50-something with Regular Wide Complex Tachycardia: What to do if electrical cardioversion does not work?
Case submitted by anonymous. Written by Smith. Ken ' s piece at the bottom is excellent.A 50-something presented with sudden onset palpitations 8 hrs prior while sitting at desk at work. He had concurrent sharp substernal chest pain that resolved, but palpitations continued.Over past 3 months, he has had similar intermittent episodes of sharp chest pain while running, but none at rest. Past medical history includes coronary stenting 17 years prior. A brief chart review revealed his most recent echo in 2018, with LV EF 67%, “very small” inferior wall motion abnormality.Initial ED ECG:What do you think?This wa...
Source: Dr. Smith's ECG Blog - September 20, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs

A 50-something with Regular Wide Complex Tachycardiaa: What to do if electrical cardioversion does not work?
Case submitted by anonymous. Written by Smith. Ken ' s piece at the bottom is excellent.A 50-something presented with sudden onset palpitations 8 hrs prior while sitting at desk at work. He had concurrent sharp substernal chest pain that resolved, but palpitations continued.Over past 3 months, he has had similar intermittent episodes of sharp chest pain while running, but none at rest. Past medical history includes coronary stenting 17 years prior. A brief chart review revealed his most recent echo in 2018, with LV EF 67%, “very small” inferior wall motion abnormality.Initial ED ECG:What do you think?This wa...
Source: Dr. Smith's ECG Blog - September 20, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs

How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you… Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China. I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1 We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004. Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news

Multimodality approach to treat calciphylaxis in end-stage kidney disease patients
Ren Fail. 2023;45(2):2256413. doi: 10.1080/0886022X.2023.2256413. Epub 2023 Sep 19.ABSTRACTA multimodality approach has been proposed as an effective treatment for calciphylaxis in patients with end-stage kidney disease. In this retrospective study, we report the cases of 12 end-stage kidney disease patients from l'Hôtel-Dieu de Québec hospital (Canada) who were diagnosed with calciphylaxis between 2004 and 2012 and treated with a multimodality clinical approach including sodium thiosulfate (STS). Statistical analyses were performed to evaluate the impacts of patients characteristics, the different interventions as well ...
Source: Renal Failure - September 19, 2023 Category: Urology & Nephrology Authors: Chlo é Lajoie Abdelaziz Ghanemi Kateri Bourbeau Aboubacar Sidib é Yue-Pei Wang Simon Desmeules Fabrice Mac-Way Source Type: research

Transient left bundle branch block associated with very high coronary artery calcium: a case report
We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L). Repeat ECG in the emergency department showed normal sinus rhythm (heart rate of 80 beats/min); however, it subsequently demonstrated a left bundle branch block (LBBB) with a repeat hsTnI of 7 ng/L. Stress testing with pharmacologic single-photon emission computerized tomography...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Alexander C Razavi Sindhu Prabakaran Mariem Sawan Lakshmi Tummala Ifeoma Onuorah Sagar B Amin Marly van Assen Carlo N De Cecco Arshed A Quyyumi Seamus P Whelton Laurence S Sperling Francois G Rollin Source Type: research

The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
Conclusion The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.
Source: Annals of the Rheumatic Diseases - September 19, 2023 Category: Rheumatology Authors: Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., Fuller, A., Rosenthal, A., Becce, F., Bardin, T., Ea, H.-K., Filippou, G., Fitzgerald, J., Iagnocco, A., Liote, F., McCarthy, G. M., Ramonda, R., Richette, P., Sivera, F., A Tags: ARD, EULAR papers Criteria Source Type: research

Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
In conclusion, C5aR1 inhibition is proposed as a therapeutic option with the potential to exert long-term protective effect on PIPN-associated neuropathic pain and inflammation.PMID:37722320 | DOI:10.1016/j.cyto.2023.156370
Source: Cytokine - September 18, 2023 Category: Molecular Biology Authors: C Cristiano C Giorgio P Cocchiaro S Boccella M C Cesta V Castelli F M Liguori M R Cuozzo L Brandolini R Russo M Allegretti Source Type: research

Oxidative stress by the mitochondrial monoamine oxidase B mediates calcium pyrophosphate crystal ‐induced arthritis
ConclusioniMAO-Bs dampen inflammation in murine models of crystal-induced arthropathy, thereby uncovering MAO-B as a promising target to treat these diseases.
Source: Arthritis and Rheumatology - September 12, 2023 Category: Rheumatology Authors: Francisca C. Venegas, Ricardo S ánchez‐Rodríguez, Roberto Luisetto, Roberta Angioni, Antonella Viola, Marcella Canton Tags: Brief Report Source Type: research

Comparison of Blood Lead Levels in Children and Adolescents with and without Functional Abdominal Pain
CONCLUSION: We found that the lead level was higher in patients with FGID than in the controls; however, this difference was not significantly different. This might be because of elevated lead levels in both groups. Future ecological studies with a large sample size are necessary in this regard.PMID:37694233 | PMC:PMC10492617 | DOI:10.4103/abr.abr_250_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Fatemeh Famouri Maryam Yazdi Awat Feizii Hossein Saneian Peiman Nasri Roya Kelishadi Source Type: research

An Unusual Cause of Fever, Neck Pain, and Neck Stiffness: Acute Calcific Tendinitis of the Longus Colli Muscle
J Emerg Med. 2023 Jun 10:S0736-4679(23)00316-5. doi: 10.1016/j.jemermed.2023.05.023. Online ahead of print.ABSTRACTBACKGROUND: Acute calcific tendinitis (ACT) of the longus colli muscle (LCM) is an inflammatory response due to deposition of calcium hydroxyapatite crystals. It is typically correlated with whiplash and overuse injuries. A common presentation of this inflammatory response is acute but progressive neck pain. It is a rare but important cause of neck pain that should be considered on a differential diagnosis when distinguishing between life-threatening conditions and non-life-threatening causes of neck pain.CASE...
Source: Pain Physician - September 10, 2023 Category: Anesthesiology Authors: Isabella Reitz Christopher Allen Douglas E Rappaport Source Type: research

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