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Total 3990 results found since Jan 2013.
Glutamatergic Neurons in the Zona Incerta Modulate Pain and Itch Behaviors in Mice
AbstractEmerging evidence suggest that parvalbumin neurons in zona incerta (ZI) modulate pain and itch behavior in opposite manners. However, the role of ZI glutamatergic neurons, a unique incertal neuronal subpopulation residing in the caudal division, in pain and itch modulation remains unknown. In the present study, by combining chemogenetic manipulation, fiber photometry, and behavioral tests, we proved that incertal glutamatergic neurons served as an endogenous negative diencephalic modulator for both pain and itch processing. We demonstrated that ZI vesicular glutamate transporter 2 (VGluT2) neurons exhibited increas...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research
How to Start Foraging for Vegetables in the Sea
Food costs in the U.S. are rising at the fastest rate in two decades, creating incentives to find new and unconventional ways of sourcing meals. While summer may be peak gardening season, for foragers, the approach of fall—and with it, peak mushroom season—marks a time of plenty.
Good wild eats, however, aren’t just limited to those near the forests. If you’re in a coastal state and heading to the beach for one last summer swim, there may still be time to indulge in one of the most underrated native foods in your area: sea vegetables. Looking to the ocean to beef up your grocery haul might not so...
Source: TIME: Health - September 6, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized healthscienceclimate Source Type: news
The Effects of Calcium Silicate- and Calcium Hydroxide-Based Root Canal Sealers on Postoperative Pain: A Randomized Clinical Trial
This study aimed to compare the postoperative pain level changes resulting from using calcium silicate- (Endoseal MTA) and calcium hydroxide-based (Sealapex) root canal sealers in mandibular first and second molar teeth with symptomatic apical periodontitis.
Source: Journal of Endodontics - September 6, 2023 Category: Dentistry Authors: Mine B üker, Meltem Sümbüllü, Afzal Ali, Oğuzhan Ünal, Hakan Arslan Tags: CONSORT Randomized Clinical Trial Source Type: research
Sub-chondroplasty Reduces Pain, Improves Function and Delays the Conversion to Arthroplasty in Patients with Advanced Knee Osteoarthritis: A Stratified Meta-analysis and Quality Assessment
J Surg Orthop Adv. 2023 Summer;32(2):65-74.ABSTRACTThere is an ongoing interest in alternatives to total knee arthroplasty, as a means to delay inevitable replacement. A possible, minimally invasive, alternative is a sub-chondroplasty, involving interosseous injection of bone substitute materials such as calcium phosphate (CaPo4), platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC) or Injectable demineralized bone matrix (iDBM) into the subchondral bone. Eleven clinical trials were found, investigating the effectiveness of sub-chondroplasties performed using CaPo4, PRP, BMAC, and iDBM. A non-stratified and ...
Source: Journal of surgical orthopaedic advances - September 5, 2023 Category: Orthopaedics Authors: Mariana Roldan Mohamed E Awad Trey D VanAken Wael Saasouh Padmavathi Patel Gamal Mostafa Khaled J Saleh Source Type: research
