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Total 94 results found since Jan 2013.
Two cases of dermatomyositis associated with neuroendocrine tumors
AbstractDermatomyositis is an idiopathic inflammatory myopathy with cutaneous manifestations, which is associated with several types of malignancies, yet it has been rarely linked to neuroendocrine tumors (NETs). Here we report two cases of dermatomyositis associated with NETs of differing primary sites. Case 1: A 46-year-old female presented with a facial rash and proximal muscle weakness of both extremities. Investigations revealed elevated creatine kinase (CK) and positive anti-transcriptional intermediary factor 1- γ antibody (TIF1γ). The patient had been diagnosed with dermatomyositis and underwent a total body CT s...
Source: International Cancer Conference Journal - August 31, 2023 Category: Cancer & Oncology Source Type: research
Usefulness of nabilone as an antiemetic in persistent vomiting due to refractory gastrointestinal disorders
Rev Esp Enferm Dig. 2023 Jun 14. doi: 10.17235/reed.2023.9719/2023. Online ahead of print.ABSTRACTNabilone, a synthetic analogue of delta-9-Tetrahydrocannabinol, is an agonist of cannabinoid receptors (CB-1 and CB-2) approved to treat chemotherapy-induced vomiting refractory to antiemetics. Its use in patients with refractory vomiting due to gastrointestinal dysmotility (GID) has not been reported. Our study aims are to assess nabilone usefulness and side-effects in patients with refractory vomiting due to GID. Patients prescribed nabilone at St. Mark's intestinal rehabilitation unit (January 2017 to September 2022) due to...
Source: Revista Espanola de Enfermedades Digestivas - June 14, 2023 Category: Gastroenterology Authors: Cristina Olmedo Moreno Richard Holman Manni Naghibi Suzanne Donnelly Alison Culkin Lilia Malcom Nicola Vernon Simon Gabe Source Type: research
Olverembatinib Treatment in Pediatric Patients With Relapsed Philadelphia-Chromosome-Positive Acute Lymphoblastic Leukemia
Clin Lymphoma Myeloma Leuk. 2023 May 11:S2152-2650(23)00140-4. doi: 10.1016/j.clml.2023.04.012. Online ahead of print.ABSTRACTTreatment outcomes for children with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) remained poor despite the use of intensive chemotherapy, imatinib or dasatinib, and consolidative allogeneic hematopoietic cell transplantation. Oleverembatinib, a third-generation ABL inhibitor, was found to be highly effective and safe in adults with chronic myeloid leukemia and in some adults with relapsed or refractory Ph+ ALL. We reviewed the efficacy and safety profile of olverembatin...
Source: Clinical Lymphoma and Myeloma - June 10, 2023 Category: Cancer & Oncology Authors: Xiaolan Li Jingliao Zhang Fang Liu Tianfeng Liu Ranran Zhang Yumei Chen Ye Guo Yongjun Fang Xiaojun Xu Ching-Hon Pui Xiaofan Zhu Source Type: research
Immune checkpoint inhibitor therapy in a patient with small cell lung cancer and anti ‐transcriptional intermediary factor 1‐γ antibody‐positive dermatomyositis: A case report
Autoimmune diseases (ADs) such as dermatomyositis (DM) are closely related to cancers. Although there are concerns that immune checkpoint inhibitors (ICIs) may cause immune-related adverse events or exacerbate ADs, clinicians should consider ICIs for SCLC patients with DM because the treatment of malignancy by ICIs improves the symptoms of paraneoplastic AD. AbstractAutoimmune diseases (ADs) are closely related to cancers; 30% of dermatomyositis (DM) cases are associated with malignancy. In lung cancer patients accompanied by DM, the most frequent cancer type is small cell lung cancer (SCLC). Anti-transcriptional intermedi...
Source: Thoracic Cancer - August 19, 2022 Category: Cancer & Oncology Authors: Yoonjoo Kim,
Dongil Park,
Song ‐Yi Choi,
Chaeuk Chung Tags: CASE REPORT Source Type: research
Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
We report the case of a 60-year-old man who initially presented with fatigue and muscle weakness of the symmetric proximal lower limbs. Muscle biopsy did not reveal mononuclear cell infiltration, atrophy, necrosis, or positive Congo red staining results. The results of serum protein electrophoresis and immunofixation electrophoresis were negative. No specific diagnosis was established. After 1 year, the patient was diagnosed with AL amyloidosis after myocardial and fat pad biopsies were performed and myopathy was diagnosed as AL amyloidosis-associated myopathy after reassessment. The patient received CyBorD regime chemothe...
Source: Frontiers in Oncology - July 14, 2022 Category: Cancer & Oncology Source Type: research
The Impact of Resistance Exercise on Muscle Mass in Glioblastoma in Survivors (RESIST): Protocol for a Randomized Controlled Trial
CONCLUSIONS: This study will inform how individualized circuit-based resistance training may improve functional independence and overall QOL of glioblastoma patients.TRIAL REGISTRATION: ClinicalTrails.gov NCT05116137; https://www.clinicaltrials.gov/ct2/show/NCT05116137.INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/37709.PMID:35507403 | DOI:10.2196/37709
Source: Cancer Control - May 4, 2022 Category: Cancer & Oncology Authors: Melanie R Keats Scott A Grandy Christopher Blanchard Jonathon R Fowles Heather F Neyedli Adrienne C Weeks Mary V MacNeil Source Type: research
Cancers, Vol. 13, Pages 3615: Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere
balka
Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle wasting and dysfunction (i.e., myopathy). In the oncology setting, cachexia arises from synergistic insults from both cancer–host interactions and chemotherapy-related toxicity. The majority of studies have surrounded the cancer–host interaction side of cancer cachexia, often overlooking the capability of chemotherapy to induce cachectic myopathy. Accumulating evidence in experimental models of cachexia suggests that some chemotherapeutic agents rapidly induce cachectic myopathy, although the underlying ...
Source: Cancers - July 19, 2021 Category: Cancer & Oncology Authors: Dean G. Campelj Craig A. Goodman Emma Rybalka Tags: Review Source Type: research
Pneumocystis jirovecii Pneumonia in Neurologic Disorders: Is Prophylaxis Necessary?
Conclusions
The overall incidence of PJP in patients with non-neoplastic neurologic disorders is exceedingly low, raising doubt about the value of routine PJP prophylaxis in neurologic patients outside neuro-oncology. PJP infection occurs frequently in patients with malignancy or parenchymal organ failure, indicating that overall health status may serve as a predisposing factor for PJP.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Pike-Lee, T., Syed, S., Willis, M. A., Li, Y. Tags: Autoimmune diseases, Fungal infections, Myasthenia, Primary brain tumor Research Source Type: research
A Case of Pathological Complete Response and Resolution of Dermatomyositis Following Neoadjuvant Chemotherapy in HER2-Positive Early Breast Cancer
Discussion and conclusion. Similar cases in literature are commonly referred to a first-line surgery and the role of neoadjuvant chemotherapy is debatable.PMID:34073827 | DOI:10.3390/curroncol28030182
Source: Current Oncology - June 2, 2021 Category: Cancer & Oncology Authors: Marta Piras Martina Panebianco Matteo Garibaldi Michela Roberto Gioia Merlonghi Patrizia Pellegrini Paolo Marchetti Source Type: research
