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Meeting the challenges in the diagnosis of inflammatory myopathies.
Authors: Manie M Abstract Inflammatory myopathy (IM) is a rubric term to describe a heterogeneous group of muscle diseases typified by dermatomyositis and polymyositis. The current classifications are unsatisfactory, but IM associated with other connective tissue diseases (CTDs), such as systemic lupus erythematosus, underlying malignancy and HIV, should also be included. Although uncommon, IM should always be considered in a patient who presents with proximal weakness of gradual onset and has raised serum muscle enzymes. The diagnosis may be obvious if the patient has diagnostic skin signs such as heliotropic rash...
Source: South African Medical Journal - March 6, 2016 Category: African Health Tags: S Afr Med J Source Type: research

Medial humeral epicondylitis in clinically affected cats
ConclusionsCats with forelimb lameness should be evaluated for MHE. This condition is associated with free joint bodies and neurogenic myopathy. Surgical treatment is associated with excellent outcome in the majority of cats.
Source: Veterinary Surgery - August 1, 2015 Category: Veterinary Research Authors: Ronny Streubel, Thomas Bilzer, Paula Grest, Daniel Damur, Pierre M. Montavon Tags: Original Clinical Article Source Type: research

Use of dual-energy computed tomography for the evaluation of calcinosis in patients with systemic sclerosis
We examined the usefulness of dual-energy computed tomography (DECT) in the evaluation of symptomatic systemic sclerosis (SSc)-related calcinosis of the hands. We performed DECT scan of the hands in 16 patients with symptomatic SSc-calcinosis to better characterize the calcinosis, their locations within the soft tissues, and exclude monosodium urate (MSU) crystal deposition. We also compared their computed tomography (CT) images to plain radiographs of one hand. Pertinent clinical information from this cohort was collected. Sixteen SSc patients underwent DECT and plain X-ray imaging of the hands. Five of the 16 SSc patient...
Source: Clinical Rheumatology - July 3, 2015 Category: Rheumatology Source Type: research

Quickly progressive amyotrophy of the thigh: An unusual cause of rapid chondrolysis of the knee
Publication date: Available online 10 February 2015 Source:Joint Bone Spine Author(s): Maeva Ferrari , Karine Louati , Anne Miquel , Anthony Behin , Olivier Benveniste , Jérémie Sellam While rapidly destructive OA is more recognized in hip, we report the case of a 50-year-old woman who presented a rapid chondrolysis in the patellofemoral joint in a context of rapid loss of muscular strength. She had arthralgia, myalgia and proximal muscular deficit of the limbs. Creatine phospho kinase level was elevated and electromyogram exam showed a myogenic syndrome. Neither immune nor visceral disease was highlighted. As we suspe...
Source: Joint Bone Spine - February 13, 2015 Category: Orthopaedics Source Type: research

Scoliosis in Mitochondrial Myopathy: Case Report and Review of the Literature
This study presents a case of scoliosis occurring in the setting of mitochondrial myopathies and explores the possible mechanisms between the 2 diseases. A previously unreported scoliosis in mitochondrial myopathies is described. The patient was a 16-year-old Chinese adolescent boy undergoing a posterior correction at thoracic 2-lumbar 3 (T2-L3) levels using the Moss-SI spinal system. At 48-month follow-up, the patient was clinically pain free and well balanced. Plain radiographs showed solid spine fusion with no loss of deformity correction. After evaluating 60 mitochondrial myopathies, patients referred to Peking Union M...
Source: Medicine - February 1, 2015 Category: Internal Medicine Tags: Article: Clinical Case Report Source Type: research

G.p.135
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults with autosomal dominant inheritance and multisystemic involvements. The core features comprise progressive myopathy, often with a pronounced facial muscle atrophy and weakness. The aim of this study is to characterize dental and orthodontic aspects of this disease and to discuss possibles therapeutic strategies. The study concerned 16 patients, 6 women and 10 men, aged 13–63years, with the genetically proved DM1. All patients were evaluated with clinical orthodontic and dental examination as well as a panoramic radiograph and lateral cephalogram.
Source: Neuromuscular Disorders - October 1, 2014 Category: Neurology Authors: , A. Lusakowska, D. Maciejak, A.M. Kaminska, M. Zadurska Source Type: research

Moving to connective tissue disease
We present an approach to the neurological presentations of CTD and reveal possible manifestations and important treatment considerations.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Singh, A., Sivagnanasundaram, J., Doshi, A., Kock, N. Tags: Abstracts Source Type: research

G.P.135: Dental and orthodontic aspects of myotonic dystrophy type 1
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults with autosomal dominant inheritance and multisystemic involvements. The core features comprise progressive myopathy, often with a pronounced facial muscle atrophy and weakness. The aim of this study is to characterize dental and orthodontic aspects of this disease and to discuss possibles therapeutic strategies. The study concerned 16 patients, 6 women and 10 men, aged 13–63years, with the genetically proved DM1. All patients were evaluated with clinical orthodontic and dental examination as well as a panoramic radiograph and lateral cephalog...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: D. Nadaj, A. Lusakowska, D. Maciejak, A.M. Kaminska, M. Zadurska Source Type: research

Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy
Conclusions Identifying ARS-associated autoantibodies in ILD patients with or without myopathy is desirable because patients may respond well to immunosuppressive therapy, and their prognosis is better than that of patients with idiopathic forms of DAD or UIP.
Source: Journal of Clinical Pathology - July 16, 2014 Category: Pathology Authors: Schneider, F., Yousem, S. A., Bi, D., Gibson, K. F., Oddis, C. V., Aggarwal, R. Tags: Immunology (including allergy), Muscle disease, Inflammation, Interstitial lung disease, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests Original article Source Type: research

Massive gastrointestinal dilatation in a case of hereditary hollow visceral myopathy
Hereditary hollow visceral myopathy (HHVM) is a rare genetic cause of intestinal pseudo-obstruction described sparingly in the literature . A 21-year-old-male was diagnosed with HHVM based on clinical symptoms, gastroduodenal manometry demonstrating low-amplitude contractions in the stomach and small intestines, and intestinal histopathology demonstrating diffuse fibrous replacement of smooth muscle; his father was also affected, with similar manometric and histopathologic changes. He presented acutely to the Emergency Room with complaints of abdominal pain, recurrent emesis of feculent material, and severe gaseous distent...
Source: Digestive and Liver Disease - July 1, 2013 Category: Gastroenterology Authors: Robert J. Huang, Chohee Yun, Linda Nguyen Tags: Image of the Month Source Type: research

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