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Total 70 results found since Jan 2013.

Imaging of Joint and Soft Tissue Involvement in Systemic Lupus Erythematosus
AbstractPurpose of ReviewTo highlight the potential uses and applications of imaging in the assessment of the most common and relevant musculoskeletal (MSK) manifestations in systemic lupus erythematosus (SLE).Recent FindingsUltrasound (US) and magnetic resonance imaging (MRI) are accurate and sensitive in the assessment of inflammation and structural damage at the joint and soft tissue structures in patients with SLE. The US is particularly helpful for the detection of joint and/or tendon inflammation in patients with arthralgia but without clinical synovitis, and for the early identification of bone erosions. MRI plays a...
Source: Current Rheumatology Reports - July 16, 2021 Category: Rheumatology Source Type: research

P039  Muscle wasting & amp; weakness: a rare presentation of sarcoidosis
Conclusion Symptomatic myopathy is present in only 0.5-2.5% of sarcoidosis patients. This unique case highlights the heterogeneity of this disease and the vital role different diagnostic modalities play in achieving the correct diagnosis. It is also pertinent that the lymphadenopathy, found incidentally via imaging, led to the diagnosis. Although notoriously a diagnosis of exclusion, this case emphasises the importance of considering sarcoidosis even in the absence of respiratory symptoms, a raised ACE or hypercalcaemia.Disclosure C. Tomlinson: None.A. Khan: None.D. Mukerjee: None.N. Bhadauria: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

What Causes Respiratory Failure?
Discussion The respiratory system is a complex system. The upper airways must remain patient. The lower airways must interface with the vascular system. The musculoskeletal system must provide mechanical function and the central nervous system must provide overall control. Respiratory failure occurs when the overall system cannot support the body’s necessarily ventilation, oxygenation or both. Children are at higher risk of respiratory failure. They have few intrinsic lung parenchyma problems, but have very small airways that increase the airflow resistance by themselves but then have to contend with problems such as...
Source: PediatricEducation.org - December 2, 2019 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Radiographic Musculoskeletal Findings Indicating Opioid Misuse: An Overview for Orthopedic Surgeons
ConclusionKnowledge of the radiologic findings of opioid misuse will assist orthopedic surgeons in making timely diagnoses that may alter therapeutic regimens for their patients.
Source: HSS Journal - January 8, 2019 Category: Orthopaedics Source Type: research

Anti-TIF1γ antibody predicted malignancy of thymic tumor with dermatomyositis as an “autoimmune tumor marker”: A case report
We report a case of anti-TIF1γ antibody positive dermatomyositis (DM) associated with thymic carcinoma which radiographically mimicked benign tumor. Patient concerns: A 72-year-old man presented typical characteristic cutaneous manifestations and proximal muscle weakness with elevated levels of myogenic enzymes. An anterior mediastinal tumor was detected by computed tomography (CT) scan and radiographically assessed to be benign with distinct borders and little enhancement. Diagnoses: DM with anti-TIF1γ antibody and thymic carcinoma. Interventions: Thymic carcinoma was completely resected by surgery. DM was indu...
Source: Medicine - December 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Spinal Sagittal Alignment in Patients With Dropped Head Syndrome
Conclusion. Increased offset of the gravity axis of the head represented by C2-C7 SVA was observed in INEM DHS. Magnified offset of the gravity axis of the head was affected by enlarged C2S, T1S, and T1-T4 TK for the strong correlation with C2-C7 SVA, respectively. Cervical kyphosis was considered as some of the anthropometric characteristics due to regressive changes in affected individuals; a correlation between C2-C7 A and C2-C7 SVA was exhibited. Level of Evidence: 4
Source: Spine - October 16, 2018 Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research

Management of graves myopathy
A broad understanding of the different imaging modalities used to assess the physiologic changes seen in Graves' orbitopathy complement clinical examination. Subtle applications of radiographic imaging techniques allow for a better understanding of the overall physiology of the orbit, quantify progression of disease, and differentiate it from orbital diseases with overlapping features. A nuanced approach to interpreting imaging features may allow us to delineate inactive from active thyroid eye disease, and advances within this field may arm clinicians with the ability to better predict and prevent dysthyroid optic neuropathy.
Source: Journal of AAPOS - July 25, 2018 Category: Opthalmology Authors: Christopher Lo, Shoaib Ugradar, Daniel Rootman Tags: Symposium Source Type: research

Megacystis microcolon intestinal hypoperistalsis syndrome overlapping prune belly syndrome
Publication date: July 2018 Source:Journal of Pediatric Surgery Case Reports, Volume 34 Author(s): Hidehiko Maruyama, Yuichi Hasegawa, Rika Sugibayashi, Yuka Iwasaki, Shuhei Fujino, Shoichiro Amari, Junko Nagasawa, Yuka Wada, Hideshi Fujinaga, Keiko Tsukamoto, Kazunori Tahara, Takako Yoshioka, Yushi Ito, Haruhiko Sago Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare congenital visceral myopathy. We experienced a case of an infant with MMIHS with prune belly syndrome (PBS). A pregnant woman was transferred at 16 gestational weeks for a cyst in the fetal bladder. Fetal bladder punctures and a vesi...
Source: Journal of Pediatric Surgery Case Reports - June 30, 2018 Category: Surgery Source Type: research

Vasculitis and neurobrucellosis: Evaluation of nine cases using radiologic findings
ConclusionsWe aimed to present our cases due to the fact that this disease should be kept in mind in the differential diagnosis of patients with stroke and similar neuropsychiatric findings. Vascular syndromes are rarely seen in inflammation in Neurobrucellosis. Neurobrucellosis should be kept in mind in the differential diagnosis of stroke and patients with similar neuropsychiatric findings.
Source: Brain and Behavior - March 1, 2018 Category: Neurology Authors: Sule Aydin Turkoglu, Siddika Halicioglu, Fatma Sirmatel, Murside Yildiz, Nebil Yildiz, Serpil Yildiz Tags: ORIGINAL RESEARCH Source Type: research

Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy.
CONCLUSIONS: - Lung disease is often the first manifestation of anti-PL-12 ARS. There are no pathognomonic histopathologic features to distinguish anti-PL-12 ARS-related lung disease from idiopathic variants of diffuse interstitial lung disease. Increased inflammation, lymphoid aggregates, and nonspecific interstitial pneumonia-like areas in a biopsy, as well as clinical features of mechanic's hands, Raynaud phenomenon, arthritis, and fever, should prompt pathologists to suggest involvement by ARS. PMID: 28967806 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - October 2, 2017 Category: Laboratory Medicine Authors: Schneider F, Yousem SA, Oddis CV, Aggarwal R Tags: Arch Pathol Lab Med Source Type: research

Progressive hypoventilation due to mixed CD8 + and CD4 + lymphocytic polymyositis following tremelimumab - durvalumab treatment
ConclusionsThis case supports the hypothesis that muscle tissue is a target for lymphocytic infiltration in immune checkpoint inhibitor-associated polymyositis. Further insights into the autoimmune mechanism of PM will hopefully contribute to the prevention and treatment of this phenomenon.
Source: Journal for Immunotherapy of Cancer - July 18, 2017 Category: Cancer & Oncology Source Type: research

Familial Early-Onset Paget ’s Disease of Bone Associated with a Novel hnRNPA2B1 Mutation
We describe here a novel missense mutation inhnRNPA2B1 gene in a large pedigree affected with PDB with members who do not present other manifestations of multisystem proteinopathy, such as IBM, FTD, and ALS.
Source: Calcified Tissue International - April 7, 2017 Category: Orthopaedics Source Type: research

IgG4-related disease causing facial nerve and optic nerve palsies: Case report and literature review
We report a rare care of a 61-year-old female with IgG4-RD presenting as synchronous lesions of the middle ear and middle cranial fossa with polyneuropathy of cranial nerves II, VI, and VII. Initial histopathological evaluation of her resected ear mass suggested a benign inflammatory process but no specific diagnosis. Her symptoms progressed over 10months prompting re-evaluation of the specimen and consideration of the IgG4-RD diagnosis. Key pathologic features included prominent lymphoplasmacytic population, storiform fibrosis, obliterative phlebitis, and IgG4 specific staining. The patient was treated with high-dose intr...
Source: American Journal of Otolaryngology - September 26, 2016 Category: Endocrinology Source Type: research

Pediatric presentation of Marinesco –Sjögren syndrome with a novel SIL1 mutation in two siblings
Marinesco –Sjögren syndrome (MSS) is an autosomal recessive multisystem disorder characterized by cerebellar ataxia with cerebellar atrophy, early onset cataracts, progressive myopathy, hypotonia, and mild to severe intellectual disability. Children with MSS usually present with muscular hypotonia in early infancy; distal and proximal muscular weakness is noticed during the first decade of life. Diagnosis is based on a clinic approach including radiographic and neuroimaging studies, but ultimately based molecular genetics.
Source: Neuromuscular Disorders - September 10, 2016 Category: Neurology Authors: A. Ka çar Bayram, N. Bayram, S. Çırak, S. Doğanay, H. Gumus, H. Per Source Type: research

Clinical Reasoning: A 33-year-old man with cardiomyopathy and myopathy
An 18-year-old Hmong man sought medical care because of worsening performance on military training exercises. He had a previous syncopal episode with prompt recovery. His medical and developmental history were otherwise unremarkable. A chest radiograph revealed cardiomegaly and, after further cardiac tests, he was diagnosed with postinfectious or idiopathic cardiomyopathy. His cardiac function deteriorated and heart transplantation was pursued. During preoperative evaluation, his serum creatine kinase (CK) was noted to be persistently elevated in the 4,000s, prompting further investigation, but since he was not weak or oth...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Foster, L. A., Courville, E. L., Manousakis, G. Tags: Lipidoses, Muscle disease, Cardiac, All Genetics RESIDENT AND FELLOW SECTION Source Type: research