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Total 106 results found since Jan 2013.
Generation of CHOPi012-A iPSC line from a patient with visceral myopathy-related chronic intestinal pseudo-obstruction
Stem Cell Res. 2023 Aug 1;71:103176. doi: 10.1016/j.scr.2023.103176. Online ahead of print.ABSTRACTVisceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening abdominal distension, and may depend on intravenous nutrition for survival. Unfortunately, our limited understanding of the pathophysiology of visceral myopathies means that current therapies remain supportive, with no mechanism-based treatments. We developed a patient-derived iP...
Source: Cell Research - August 12, 2023 Category: Cytology Authors: Sohaib K Hashmi Sabine Schneider Alyssa L Gagne Jean Ann Maguire Paul Gadue Robert O Heuckeroth Deborah L French Source Type: research
The association between C-peptide and atrial cardiomyopathy in nondiabetic adults: results from NHANES III
AbstractSerum C-peptide exhibits various biological activities. The relationship between C-peptide and atrial cardiomyopathy remains unknown. We aimed to investigate the association between C-peptide level and atrial cardiomyopathy in nondiabetic adults. Our study enrolled 4578 participants without diagnosed diabetes from the Third National Health and Nutrition Examination Survey (NHANES III). Atrial cardiomyopathy was defined as a deep terminal negative P wave in V1 below − 100 µV (more negative), according to the electrocardiogram. The participants were categorized into low C-peptide (≤ 1.46 nmol/L) and high C-...
Source: Heart and Vessels - July 15, 2023 Category: Cardiology Source Type: research
Usefulness of nabilone as an antiemetic in persistent vomiting due to refractory gastrointestinal disorders
Rev Esp Enferm Dig. 2023 Jun 14. doi: 10.17235/reed.2023.9719/2023. Online ahead of print.ABSTRACTNabilone, a synthetic analogue of delta-9-Tetrahydrocannabinol, is an agonist of cannabinoid receptors (CB-1 and CB-2) approved to treat chemotherapy-induced vomiting refractory to antiemetics. Its use in patients with refractory vomiting due to gastrointestinal dysmotility (GID) has not been reported. Our study aims are to assess nabilone usefulness and side-effects in patients with refractory vomiting due to GID. Patients prescribed nabilone at St. Mark's intestinal rehabilitation unit (January 2017 to September 2022) due to...
Source: Revista Espanola de Enfermedades Digestivas - June 14, 2023 Category: Gastroenterology Authors: Cristina Olmedo Moreno Richard Holman Manni Naghibi Suzanne Donnelly Alison Culkin Lilia Malcom Nicola Vernon Simon Gabe Source Type: research
Weight Loss, Muscular Dystrophy And Other Myopathies
Rationale: Weight loss, in a young person without patology, is usually associated with anorexia nervosa. If this person has an elevated creatine phosphokinase (CPK) we could think in a congenital metabolic disease. If we put together, sarcopenia with elevated CPK, we must review the diagnosis of myopathy.
Source: Clinical Nutrition ESPEN - March 23, 2023 Category: Nutrition Authors: M.D. Gosalbez, M. Diez, I. Tejado, J. Pi, A. Fontalba, L. Riancho, J. Riancho Source Type: research
What to Know if Your Doctor Put You on Statins to Lower Cholesterol
High cholesterol is a prime example of having too much of a good thing. Our bodies naturally make this substance in the liver and then transport it throughout the body for multiple functions, including hormone regulation, cell tissue regeneration, and vitamin absorption. When the system is working well, cholesterol can boost overall health. But when a certain type called low-density lipoprotein—LDL, sometimes dubbed the “bad” kind—is overproduced, not only does it block the “good” kind called high-density lipoprotein (HDL), but it can also begin to accumulate in the arteries and form thi...
Source: TIME: Health - January 25, 2023 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized healthscienceclimate heart health Source Type: news
Exercise and nutrition in critically ill patients-What is the correct formula?
ICU-acquired weakness is diagnosed in approximately 1 million mechanically ventilated patients annually.1 This weakness is secondary to multiple mechanisms including myopathy, neuropathy, deconditioning and protein malnutrition. In addition, ICU-acquired weakness is associated with decreased quality of life and increased mortality.2 Physical rehabilitation and nutritional support have the potential to improve muscle strength and help maintain functional status.
Source: Heart and Lung - January 24, 2023 Category: Intensive Care Authors: Margaret A. Pisani Source Type: research
Clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia
Conclusions: 1. The RSU has allowed us to assume the great demand for care of seriously ill patients derived from the current COVID-19 pandemic. 2. Non-invasive ventilation techniques are a valid alternative for the treatment of hypoxemic respiratory failure refractory to conventional oxygen therapy in these patients.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Tarrega Camarasa, J., Castillo Sanchez, I., Bruguet Gonzalez, J., Galea Colon, Y., Angrill Selles, N., Barbeta Sanchez, E. Tags: 02.01 - Acute critical care Source Type: research
Diabetes mellitus tendino-myopathy: epidemiology, clinical features, diagnosis and management of an overlooked diabetic complication
AbstractTendino-myopathy, an unexplored niche, is a non-vascular unstated T2DM complication, which is largely disregarded in clinical practice, thus, we aim to explore it in this review. Literature search using published data from different online resources. Epidemiologically, reported prevalence varies around 10 –90%, which is marked variable and unreliable. Clinically, diabetic tendino-myopathy is typified by restriction of movement, pain/tenderness, cramps and decreased functions. Moreover, myopathy is characterized by muscle atrophy, weakness and ischemia, and tendinopathy by deformities and reduced fu nctions/precis...
Source: Acta Diabetologica - June 3, 2022 Category: Endocrinology Source Type: research
