Filtered By:
Nutrition: Diets

This page shows you your search results in order of date.

Order by Relevance | Date

Total 84 results found since Jan 2013.

Case report: Mitochondrial trifunctional protein deficiency caused by HADHB gene mutation (c.1175C > T) characterized by higher brain dysfunction followed by neuropathy, presented gadolinium enhancement on brain imaging in an adult patient
Mitochondrial trifunctional protein (MTP) deficiency is an autosomal recessive disorder caused by impaired metabolism of long-chain fatty acids (LCFAs). Childhood and late-onset MTP deficiency is characterized by myopathy/rhabdomyolysis and peripheral neuropathy; however, the features are unclear. A 44-year-old woman was clinically diagnosed with Charcot-Marie-Tooth disease at 3 years of age due to gait disturbance. Her activity and voluntary speech gradually decreased in her 40s. Cognitive function was evaluated and brain imaging tests were performed. The Mini-Mental State Examination and frontal assessment battery scores...
Source: Frontiers in Neurology - June 13, 2023 Category: Neurology Source Type: research

Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of Peripheral Artery Disease
Transl Res. 2023 May 21:S1931-5244(23)00088-9. doi: 10.1016/j.trsl.2023.05.002. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although PAD incidence increases with age, and obesity is a common comorbidity, the pathophysiologic association between these risk factors and PAD myopathy is unknown. Using our murine model of PAD, we sought to elucidate the combined effect of age, diet-induced obesity and chronic hindlimb ischemia (H...
Source: Translational Research : the journal of laboratory and clinical medicine - May 23, 2023 Category: Laboratory Medicine Authors: Emma Fletcher Dimitrios Miserlis Kristina Sorokolet Dylan Wilburn Cassandra Bradley Evlampia Papoutsi Trevor Wilkinson Andrew Ring Lucas Ferrer Gleb Haynatzki Robert S Smith William T Bohannon Panagiotis Koutakis Source Type: research

Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota
Biomed Pharmacother. 2023 May 6;163:114837. doi: 10.1016/j.biopha.2023.114837. Online ahead of print.ABSTRACTSepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 8, 2023 Category: Drugs & Pharmacology Authors: Yukun Liu Ligang Xu Zhaohui Yang Dongfang Wang Tianyu Li Fan Yang Zhanfei Li Xiangjun Bai Yuchang Wang Source Type: research

Skeletal muscle single fiber force production declines early in juvenile male mice with chronic kidney disease
Juvenile mice with early-stage CKD display reduced single fiber contractile function. Cellular force production is lower primarily due to less strongly bound myosin-actin cross-bridges. Additionally, myosin-actin cross-bridge kinetics slow in myosin heavy chain IIA fibers. AbstractChildren with chronic kidney disease (CKD) frequently exhibit delayed physical development and reduced physical performance, presumably due to skeletal muscle dysfunction. However, the cellular and molecular basis of skeletal muscle impairment in juvenile CKD remains poorly understood. Cellular (single fiber) and molecular (myosin-actin interacti...
Source: Physiological Reports - April 6, 2023 Category: Physiology Authors: Brent A. Momb, Edwin Patino, Oleh M. Akchurin, Mark S. Miller Tags: ORIGINAL ARTICLE Source Type: research

Molecules, Vol. 27, Pages 8016: Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its Glucoside & mdash;A Theoretical Approach
Molecules, Vol. 27, Pages 8016: Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its Glucoside—A Theoretical Approach Molecules doi: 10.3390/molecules27228016 Authors: Rangasamy Praveena Athinarayanan Balasankar Kanakaraj Aruchamy Taehwan Oh Veerababu Polisetti Subramaniyan Ramasundaram Kandasamy Anbazhakan Anthocyanins are an important pharmaceutical ingredient possessing diet regulatory, antioxidant, anticancer, antidiabetic, anti-obesity, antimicrobial, and anti-inflammatory properties. Pelargonidin is an important anthocyanin-based orange-red flavonoid compound used in...
Source: Molecules - November 18, 2022 Category: Chemistry Authors: Rangasamy Praveena Athinarayanan Balasankar Kanakaraj Aruchamy Taehwan Oh Veerababu Polisetti Subramaniyan Ramasundaram Kandasamy Anbazhakan Tags: Communication Source Type: research

Protective effect of Lactococcus laudensis and Pediococcus parvulus against neuropathy due to amyloid-beta in Caenorhabditis elegans
In conclusion, LL and PP alleviate neurotoxicity by inhibiting Aβ accumulation; AD model worms can be used to screen efficient LAB for AD prevention.PMID:36271552 | DOI:10.1016/j.biopha.2022.113769
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Tomomi Komura Motoshi Aoki Satoshi Kotoura Yoshikazu Nishikawa Source Type: research

Calorie Restriction Rescues Mitochondrial Dysfunction in Adck2-Deficient Skeletal Muscle
ADCK2 haploinsufficiency-mediated mitochondrial coenzyme Q deficiency in skeletal muscle causes mitochondrial myopathy associated with defects in beta-oxidation of fatty acids, aged-matched metabolic reprogramming, and defective physical performance. Calorie restriction has proven to increase lifespan and delay the onset of chronic diseases associated to aging. To study the possible treatment by food deprivation, heterozygous Adck2 knockout mice were fed under 40% calorie restriction (CR) and the phenotype was followed for 7 months. The overall glucose and fatty acids metabolism in muscle was restored in mutant mice to WT...
Source: Frontiers in Physiology - July 14, 2022 Category: Physiology Source Type: research

Prior Alcohol Use does not Enhance Skeletal Muscle Atrophy and Force Decrements Induced by Cancer Cachexia
CONCLUSIONS: Tumor-bearing mice produced less force during a tetanic stimulation and fatigue protocol, in accordance with significant muscle atrophy of the triceps surae. The prior consumption of EtOH did not worsen cancer-induced deficits in skeletal muscle contraction. As it has been shown previously that the continuation of EtOH throughout the progression of cancer enhances cancer cachexia, these data exemplify the clinical benefits of stopping EtOH consumption as early as possible.PMID:35556305 | DOI:10.1096/fasebj.2022.36.S1.R2968
Source: Cancer Control - May 13, 2022 Category: Cancer & Oncology Authors: Joseph A Laudato Abby T Tice Blake O Bridges Michael L Rossetti Bradley S Gordon Jennifer L Steiner Source Type: research