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Total 84 results found since Jan 2013.
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat-high sucrose-feeding
Can J Physiol Pharmacol. 2021 Oct 25. doi: 10.1139/cjpp-2021-0587. Online ahead of print.ABSTRACTSarco(endo)plasmic reticulum calcium (Ca2+) ATPase (SERCA) transports Ca2+ in muscle. Impaired SERCA activity contributes to diabetic myopathy. Sirtuin (SIRT) 3 regulates muscle metabolism and function. However, it is unknown if SIRT3 regulates muscle SERCA activity. We determined if SIRT3 overexpression enhances SERCA activity in mouse gastrocnemius muscle and if SIRT3 overexpression preserves gastrocnemius SERCA activity in a model of type 2 diabetes, induced by high fat-high sucrose (HFHS)-feeding. We also determined if the ...
Source: Canadian Journal of Physiology and Pharmacology - October 25, 2021 Category: Drugs & Pharmacology Authors: Christopher Oldfield Teri L Moffatt Vernon W Dolinsky Todd A Duhamel Source Type: research
Study of metabolomics in selenium deprived Przewalski's Gazelles ( < em > P. przewalskii < /em > )
Br J Nutr. 2021 Sep 13:1-29. doi: 10.1017/S000711452100355X. Online ahead of print.ABSTRACTTo understand why P. przewalskii does not show the same white myopathy as sheep in Se-deficient regions, and to provide reference for feeding nutrition level of artificial population and selection of wild reintroduction areas in the later period, a Se-deficient model was established. The mineral elements content, physiological and biochemical parameters in blood, and serum metabonomics were determined. In the Se-deficient group compared with the control group, the Se content was highly significantly lower (P<0.01), and the Cu cont...
Source: The British Journal of Nutrition - September 13, 2021 Category: Nutrition Authors: Ting Wu Jian He Xiaoyun Shen Source Type: research
Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study
This study set out to optimize simvastatin (SV) in lipid nanoparticles (SLNs) to improve bioavailability, efficacy and alleviate adverse effects. Simvastatin-loaded solid lipid nanoparticles (SV-SLNs) were prepared by hot-melt ultrasonication method and optimized by box-Behnken experimental design. Sixty Wister albino rats were randomly assigned into six groups and treated daily for 16 weeks: control group, the group fed with 20 g of high-fat diet (HFD), group treated with vehicle (20 mg/kg, P.O.) for last four weeks, group treated with HFD and SV (20 mg/kg, P.O.) / or SV-SLNs (20 mg/kg/day, P.O.) / or SV-SLNs (5 mg/kg, P....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Hagar B Abo-Zalam Ezzeldein S El-Denshary Rania M Abdelsalam Islam A Khalil Mahmoud M Khattab Mohamed A Hamzawy Source Type: research
Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma –Induced Cancer Cachexia
In this study, we investigated whether preemptive administration of NR ameliorated C26 adenocarcinoma–induced cancer cachexia and explored anti-cachexic mechanisms focused on the changes in muscle atrophy, cachexic inflammation, and catabolic catastrophe. Dietary intake of the NR-containing pellet diet significantly attenuated cancer cachexia in a mouse model. Starting with significant inhibition of cachexic factors, tumor necrosis factor alpha, and interleukin-6, NR significantly inhibited muscle-specific ubiquitin-proteasome ligases, such as atrogin-1, muscle RING-finger protein-1 (MuRF-1), mitofusin-2, and peroxisome ...
Source: Frontiers in Pharmacology - June 28, 2021 Category: Drugs & Pharmacology Source Type: research
Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice
The objective of the present study was to compare the adenine diet and 5/6 nephrectomy (5/6 Nx) models in mice. Male and female 10-week-old C57BL/6J mice (N=5-9/sex/group) were randomly allocated to CKD groups (0.2-0.15% adenine-supplemented diet or 5/6 Nx surgery) or corresponding control groups (casein diet or sham surgery). Glomerular filtration rate was reduced to a similar level in adenine and 5/6 Nx mice (adenine male: 81.1 ± 41.9 µL/min vs. 5/6 Nx male: 160 ± 80.9 µL/min, P=0.5875; adenine female: 112.9 ± 32.4 µL/min vs. 5/6 Nx female: 107.0 ± 45.7 µL/min, P=0.9995). Serum metabolomics analysis indicated tha...
Source: Am J Physiol Renal P... - June 14, 2021 Category: Urology & Nephrology Authors: Kyoungrae Kim Erik M Anderson Trace Thome Guanyi Lu Zachary R Salyers Tomas A Cort Kerri A O'Malley Salvatore T Scali Terence E Ryan Source Type: research
