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Drug: Methylprednisolone

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Total 104 results found since Jan 2013.

Severe MDA5 dermatomyositis associated with cancer and controlled by JAK inhibitor.
We report the case of a 60-year-old woman referred to our hospital for an anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis (MDA5 DM) with rapidly progressive interstitial pneumonia, typical cutaneous features and muscular impairment. Treatment with high-dose methylprednisolone, cyclophosphamide and gamma globulin was performed, but the patient remained corticodependant. Blood detection of positive interferon signature justified the administration of an anti-JAK1/2, leading to the clinical remission and the regression of the interferon signature. After 12 months of follow up, a small cell ca...
Source: Revue de Medecine Interne - March 21, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Methotrexate as an Adjuvant in Severe Thyroid Eye Disease: Does It Really Work as a Steroid-Sparing Agent?
Conclusions: The results demonstrated improved vision and disease activity at 3 months in the combination treatment group. This may suggest that the addition of methotrexate to methylprednisolone is beneficial for accelerating suppression of disease activity and hastens visual recovery. Addition of methotrexate to methylprednisolone did not reduce the requirement for steroids.
Source: Ophthalmic Plastic and Reconstructive Surgery - July 1, 2019 Category: Opthalmology Tags: Original Investigations Source Type: research

Intravenous human immunoglobulin and/or methylprednisolone pulse therapies as a possible treat-to-target strategy in immune-mediated necrotizing myopathies
AbstractTo evaluate the relevance of immunoglobulin (IVIg) and/or methylprednisolone pulse therapies in immune-mediated necrotizing myopathy (IMNM). Secondarily, to analyze the muscle damage measured by late magnetic resonance images (MRI). This retrospective study included 13 patients with defined IMNM (nine patients positive for the anti-signal recognition particle and four patients positive for hydroxyl-methyl-glutaryl coenzyme A reductase) who were followed from 2012 to 2018. International Myositis Assessment and Clinical Studies Group (IMACS) scoring  assessed the response to a standardized treat-to-target protocol w...
Source: Rheumatology International - June 11, 2019 Category: Rheumatology Source Type: research

Rhabdomyolysis in patients treated by corticosteroids for acute asthma in intensive care unit.
CONCLUSION: This necrosing myopathy under high doses of corticosteroids has been described in patients with severe acute asthma. The mechanism of the muscle damage results from a combination of corticosteroids toxicity, respiratory acidosis and mechanic ventilation. PMID: 30616928 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - January 10, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia: A case report
Rationale: Idiopathic inflammatory myopathies have been extensively reported associated with malignancy. Immune-mediated necrotizing myopathy (IMNM), however, has rarely been connected with malignancy including acute myeloid leukemia (AML). Patient concerns: A 65-year-old woman was diagnosed with AML and received regular chemotherapy. After the 5th cycle chemotherapy, she achieved complete remission but developed severe muscle weakness and myalgia with dramatic increasing creatine kinase (CK). Diagnosis: The positivity of antinuclear matrix protein 2 antibody (anti-NXP2 Ab) and muscle biopsy in together confirmed t...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Clinical, histological and radiological responses to methylprednisolone in HIV-associated rod myopathy
• HIV patients with proximal weakness must be evaluated for sporadic late-onset nemaline myopathy.• MRI is helpful in identifying inflammatory process in HIV-associated rod myopathy.• Rod myopathy in HIV patients might be caused by an immune dysregulation.
Source: Neuromuscular Disorders - May 12, 2017 Category: Neurology Authors: Andr é M.S. Silva, Rodrigo H. Mendonça, Cristiane A.M. Moreno, Eduardo P. Estephan, Paulo V.P. Helito, Mary S. Carvalho, Edmar Zanoteli Tags: Case report Source Type: research

Mitochondrial Skeletal and Cardiac Myopathy Responsive to Aggressive Immunosuppression in Rapidly Progressing Systemic Sclerosis (P5.077)
Conclusions:Perivascular epimysial inflammation is rarely seen in any disease. Mitochondrial myopathy without myositis has not been reported in systemic sclerosis. We propose that ischemia caused by vasculopathy and fibrosis in systemic sclerosis, together with subclinical mitochondrial pathology, severely affected skeletal and cardiac muscle due to their high metabolic demands. An unusual presentation of myopathy in autoimmune disease suggests an underlying latent pathology, such as mitochondrial myopathy. Rapidly progressing autoimmune disease necessitates aggressive immunosuppression.Disclosure: Dr. Yeo has nothing to d...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yeo, C., Bunin, V., Jovan, P., Cykowski, M., Smith, R. Tags: Neuromuscular and Clinical Neurophysiology (EMG) ePoster Session Source Type: research

Necrotising myopathy associated with anti-signal recognition particle (anti-SRP) antibody.
CONCLUSIONS: Unlike the cases described in the literature, there was a high frequency of extra-muscular symptoms in the patients studied. Moreover, one fifth of patients had previous exposure to statin use. There was a high relapse rates, but with good clinical and laboratory recovery, especially with pulse therapy regimen of methylprednisolone and/or IVIg. PMID: 28281460 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - March 12, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hypokalemic myopathy in primary aldosteronism: A case report.
Authors: Wu C, Xin J, Xin M, Zou H, Jing L, Zhu C, Lei W Abstract Primary aldosteronism (PA) is a rare disorder. The majority of patients with PA present with typical features and are easily diagnosed. This disorder is usually diagnosed with hypokalemia, hypertension or an adrenal mass. However, patients with atypical symptoms may present a challenge for diagnosis and treatment. In the present study, a case of PA is described that presented with hypokalemic myopathy simulating polymyositis. The patient was a 44-year-old woman who presented with weakness and difficulty walking. The patient was initially suspected to...
Source: Experimental and Therapeutic Medicine - January 20, 2017 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Juvenile Idiopathic Inflammatory Myopathy in a Patient With Dyskeratosis Congenita Due to C16orf57 Mutation
Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. A variety of noncutaneous (dental, pulmonary, gastrointestinal, neurological, genitourinary, ophthalmic, and skeletal) abnormalities also have been reported. An 8-year-old boy with DC developed juvenile idiopathic inflammatory myopathy. C16orf57 mutation was identified as a genetic cause of DC. Treatment with methylprednisolone was initiated, followed with methotrexate, prednisolone, and high-dose intravenous immunoglobulin treatment. This is the first report on a patient with ...
Source: Journal of Pediatric Hematology Oncology - February 19, 2016 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Pulse Dose Methylprednisolone Therapy for Adult Idiopathic Inflammatory Myopathy
Idiopathic inflammatory myopathies (IIM) are a rare group of autoimmune diseases characterized by muscle inflammation. Typically high-dose daily oral corticosteroids are used as the first-line therapy of IIM. Pulse dose intravenous methylprednisolone (IVMP) has been used for serious or refractory cases. Here, we systematically analyze the therapeutic effect of pulse dose IVMP in patients with IIM in a large municipal safety net medical center and review the literature on pulse IVMP in adult IIM. We conducted a retrospective chart review of patients who were diagnosed with IIM in the rheumatology clinics of the Cook County ...
Source: American Journal of Therapeutics - July 1, 2015 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

An unusual case of inflammatory necrotizing myopathy and neuropathy with pipestem capillaries
Anil Kumar B Patil, AT Prabhakar, Ajith Sivadasan, Mathew Alexander, Geeta ChackoNeurology India 2015 63(1):72-76Necrotizing myopathy with pipestem capillaries is a form of chronic inflammatory myopathy, with histopathology showing necrotizing myopathy, minimal cellular infiltration, and microangiopathy. A 30-year-old female presented with progressive limb weakness of 6 months, with skin pigmentation and Raynaud's phenomenon. Serum creatine phosphokinase was 3990 u/L. Muscle biopsy showed necrotic fibers, focal sparse perivascular inflammation/perifascicular atrophy, endomysial/epimysial vessel wall thickening with ...
Source: Neurology India - March 4, 2015 Category: Neurology Authors: Anil Kumar B PatilAT PrabhakarAjith SivadasanMathew AlexanderGeeta Chacko Source Type: research

IgG4-Related Disease Manifesting as Middle Cranial Fossa Mass: A Case Report (P5.165)
A 62 year old woman presented with progressive right hearing loss and a right middle ear mass. Resection showed lymphoblastic inflammation. 8 months later she presented with right optic neuritis, right facial nerve paresis. Brain MRI demonstrated a dural-based homogenous enhancing mass extending from cavernous sinus into middle cranial fossa. Review of available biopsy showed plasmacytic infiltration, storiform fibrosis and phlebitis with >50 IgG4-staining cells/HPF. Serum IgG4 level was normal. Cerebrospinal fluid (CSF) revealed mild lymphocytic pleocytosis, elevated IgG index (2.2, normal <0.66), and unremarkable c...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Malla, P., Zachariah, J., Katirji, B. Tags: CNS Diseases and Differential Diagnosis Source Type: research

Towards treating lupus nephritis without oral steroids: a dream-come-true?
The discovery in the late 1940s of the very potent anti-inflammatory and immunosuppressive properties of glucocorticoids (GC)1 has dramatically improved the prognosis of severe systemic lupus erythematosus (SLE), with survival rates increasing markedly from 50% at 3 years in 19532 to 92% at 10 years in recent series.3 In particular, intravenous pulse methylprednisolone (MP) therapy, introduced as treatment for severe lupus manifestations in the 1970s,4 displays remarkable and prompt beneficial effects in acutely ill SLE patients suffering from renal impairment, central nervous system disease, arthritis, pleuroper...
Source: Annals of the Rheumatic Diseases - July 4, 2013 Category: Rheumatology Authors: Houssiau, F. A., Isenberg, D. Tags: Immunology (including allergy), Muscle disease, Ophthalmology, Renal medicine, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Osteoporosis, Systemic lupus ery Source Type: research