Mitochondrial Skeletal and Cardiac Myopathy Responsive to Aggressive Immunosuppression in Rapidly Progressing Systemic Sclerosis (P5.077)

Conclusions:Perivascular epimysial inflammation is rarely seen in any disease. Mitochondrial myopathy without myositis has not been reported in systemic sclerosis. We propose that ischemia caused by vasculopathy and fibrosis in systemic sclerosis, together with subclinical mitochondrial pathology, severely affected skeletal and cardiac muscle due to their high metabolic demands. An unusual presentation of myopathy in autoimmune disease suggests an underlying latent pathology, such as mitochondrial myopathy. Rapidly progressing autoimmune disease necessitates aggressive immunosuppression.Disclosure: Dr. Yeo has nothing to disclose. Dr. Bunin has nothing to disclose. Dr. Jovan has nothing to disclose. Dr. Cykowski has nothing to disclose. Dr. Smith has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Yeo, C., Bunin, V., Jovan, P., Cykowski, M., Smith, R. Tags: Neuromuscular and Clinical Neurophysiology (EMG) ePoster Session Source Type: research