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Drug: Methotrexate

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Total 144 results found since Jan 2013.

Statin-induced necrotizing autoimmune myopathy
We present a case of SINAM that was successfully treated with intravenous immunoglobulin.PMID:33456195 | PMC:PMC7785182 | DOI:10.1080/08998280.2020.1831298
Source: Baylor University Medical Center Proceedings - January 18, 2021 Category: Universities & Medical Training Authors: Syed A Huda Sanjay Yadava Sara Kahlown Muhammad S Farooqi Stephanie Bryant Ronald Russo Source Type: research

Clinical Characteristics, Treatment, and Outcomes in Patients with Idiopathic Inflammatory Myopathy Concomitant with Heart Failure.
In conclusion, elevated troponin I, atrial arrhythmia, and systolic and restrictive diastolic dysfunction are typical characteristics of IIM-HF. Combined immunosuppression that includes methotrexate and β-receptor blockers seems to be important to improve survival. PMID: 32999188 [PubMed - in process]
Source: International Heart Journal - October 2, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Sarcoidosis and the Nervous System
This article provides an overview and update on the neurologic manifestations of sarcoidosis. RECENT FINDINGS The 2018 Neurosarcoidosis Consortium diagnostic criteria emphasize that biopsy is key for diagnosis and determines the level of diagnostic certainty. Thus, definite neurosarcoidosis requires nervous system biopsy and probable neurosarcoidosis requires biopsy from extraneural tissue. Without biopsy, possible neurosarcoidosis can be diagnosed if the clinical, imaging, and laboratory picture is compatible and other causes are ruled out. Recent large retrospective studies from the United States and France establishe...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms.
In conclusion, the OATP1Bs are important in the hepatic uptake of endogenous chemicals, drugs, and toxicants. Because there are polymorphisms of OATP1B1, knowledge of the genotype/phenotype is of importance in diagnosing and treatment of patients. PMID: 32407928 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - May 10, 2020 Category: Toxicology Authors: Choudhuri S, Klaassen CD Tags: Toxicol Appl Pharmacol Source Type: research

Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody in necrotizing myopathy: treatment outcomes, cancer risk, and role of autoantibody level.
Conclusion: HMGCR Ab-positive NM patients are associated with statin exposure, have severe muscle weakness and high CK at presentation, lack other organ manifestations, and generally have favourable outcomes from immunosuppression. Anti-HMGCR Abs should be assessed in MSA-negative NM patients, particularly those with a history of statin exposure. PMID: 31801390 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - December 4, 2019 Category: Rheumatology Authors: Aggarwal R, Moghadam-Kia S, Lacomis D, Malik A, Qi Z, Koontz D, Burlingame RW, Oddis CV Tags: Scand J Rheumatol Source Type: research

EP.19Anti-HMGCR positive necrotizing myopathy presenting in childhood
A 12-year-old girl, previously healthy, was hospitalized because of progressive proximal weakness for a few months. CK was 17000U/L. There were only minor skin changes, but an initial muscle biopsy was reported to have changes possibly compatible with dermatomyositis. Treatment was started with prednisolone and methotrexate, without adequate improvement. A biopsy two years later did not exclude the diagnosis of a muscular dystrophy. The fast development of weakness did not however really fit clinically.
Source: Neuromuscular Disorders - September 30, 2019 Category: Neurology Authors: M. Rasmussen, A. Selvaag, S. Wallace, E. Kirkhus, E. Merckoll, E. Antal, J. Pahnke, B. Udd Source Type: research

Favorable Response in Statin-Naive Paraneoplastic Anti-HMGCR Antibody-Associated Myopathy to Single Dose of Rituximab and Persistent Remission With Management of Underlying Lung Cancer.
We report a case of a statin-naive paraneoplastic anti-HMGCR myopathy, who unlike other reported cases, responded to a single dose of 1000 mg of intravenous rituximab and subsequent chemoradiation therapy for an underlying lung cancer, despite failing to completely respond to prior high-dose oral prednisone and methotrexate. PMID: 31453850 [PubMed - in process]
Source: Clinical Lung Cancer - August 28, 2019 Category: Cancer & Oncology Authors: Waheed W, Jones C, Gentchos G, DeWitt J, Tandan R Tags: J Clin Neuromuscul Dis Source Type: research

Favorable Response in Statin-Naive Paraneoplastic Anti-HMGCR Antibody–Associated Myopathy to Single Dose of Rituximab and Persistent Remission With Management of Underlying Lung Cancer
We report a case of a statin-naive paraneoplastic anti-HMGCR myopathy, who unlike other reported cases, responded to a single dose of 1000 mg of intravenous rituximab and subsequent chemoradiation therapy for an underlying lung cancer, despite failing to completely respond to prior high-dose oral prednisone and methotrexate.
Source: Journal of Clinical Neuromuscular Disease - August 27, 2019 Category: Neurology Tags: Case Review Source Type: research