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Drug: Methotrexate
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Total 144 results found since Jan 2013.
Seronegative necrotizing autoimmune myopathy with favorable response to intravenous immunoglobulin
We describe a 68-year-old man who presented with progressive weakness in proximal muscles of all four limbs and was found to have autoantibody-negative necrotizing autoimmune myopathy (NAM). His myopathy was refractory to corticosteroids and methotrexate, but subsequently demonstrated successful response to intravenous immunoglobulin (IVIG). The patient also received rituximab, but the timing of his recovery favored IVIG as the more important factor in terms of efficacy. Treatment guidelines for seronegative necrotizing myopathies are lacking. This case suggests a potential efficacious treatment option for the seronegative...
Source: Baylor University Medical Center Proceedings - July 5, 2021 Category: Universities & Medical Training Authors: Rebecca Liu Andrew Z Fenves Samantha N Champion Jonathan Dau Source Type: research
Statin-Induced Autoimmune Necrotizing Myopathy
J Prim Care Community Health. 2021 Jan-Dec;12:21501327211028714. doi: 10.1177/21501327211028714.ABSTRACTStatin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvast...
Source: Primary Care - July 5, 2021 Category: Primary Care Authors: Sahani Jayatilaka Kunal Desai Swarup Rijal Debra Zimmerman Source Type: research
Seronegative necrotizing autoimmune myopathy with favorable response to intravenous immunoglobulin
We describe a 68-year-old man who presented with progressive weakness in proximal muscles of all four limbs and was found to have autoantibody-negative necrotizing autoimmune myopathy (NAM). His myopathy was refractory to corticosteroids and methotrexate, but subsequently demonstrated successful response to intravenous immunoglobulin (IVIG). The patient also received rituximab, but the timing of his recovery favored IVIG as the more important factor in terms of efficacy. Treatment guidelines for seronegative necrotizing myopathies are lacking. This case suggests a potential efficacious treatment option for the seronegative...
Source: Baylor University Medical Center Proceedings - July 5, 2021 Category: Universities & Medical Training Authors: Rebecca Liu Andrew Z Fenves Samantha N Champion Jonathan Dau Source Type: research
P039 Muscle wasting & amp; weakness: a rare presentation of sarcoidosis
Conclusion Symptomatic myopathy is present in only 0.5-2.5% of sarcoidosis patients. This unique case highlights the heterogeneity of this disease and the vital role different diagnostic modalities play in achieving the correct diagnosis. It is also pertinent that the lymphadenopathy, found incidentally via imaging, led to the diagnosis. Although notoriously a diagnosis of exclusion, this case emphasises the importance of considering sarcoidosis even in the absence of respiratory symptoms, a raised ACE or hypercalcaemia.Disclosure C. Tomlinson: None.A. Khan: None.D. Mukerjee: None.N. Bhadauria: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
Not just eosinophilic fasciitis
J Med Life. 2021 Jan-Mar;14(1):121-124. doi: 10.25122/jml-2021-0015.ABSTRACTThis case report describes a rare case of progressive muscle weakness in a patient treated for eosinophilic fasciitis (EF) for many years before being diagnosed with a second autoimmune disease: dermatomyositis. Our case is a report of a 65-year-old male diagnosed with eosinophilic fasciitis 7 years before being evaluated in our service at Mayo Clinic in Jacksonville, Florida, due to progressive muscle weakness despite the chronic treatment with methotrexate. Contrast-enhanced magnetic resonance imaging of the lower extremity showed enhancement thr...
Source: Journal of Medicine and Life - March 26, 2021 Category: General Medicine Authors: Razvan Chirila Elena Raluca Cristea Monica Roxana Purcarea Laura Carina Tribus Source Type: research
