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Total 144 results found since Jan 2013.
Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins
We present a case report and brief review of the literature regarding the pathogenesis, diagnosis, and management of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive IMNM (HMGCR IMNM). There are no randomised clinical trials, but several smaller studies and cases suggest a triple therapy of corticosteroids, IVIG, and a corticosteroid-sparing immunosuppressant appears efficacious in patients with IMNM and proximal weakness. The mechanism of statin-induced IMNM is uncertain, and this is further complicated by the reports of HMGCR IMNM in statin-na ïve patients, including children. We present a case of b...
Source: Rheumatology International - February 1, 2023 Category: Rheumatology Source Type: research
A Case of Statin-Associated Autoimmune Myopathy: Management and Treatment
We present a case of a male patient who developed progressively worsening muscle weakness and elevated muscle enzyme markers upon initiation of a statin. His symptoms persisted despite a trial of an alternative statin and subsequent discontinuation of all statin medications. A multitude of possible etiologies were considered and ranged from infectious, autoimmune, cancerous, to congenital in nature. Environmental factors, such as exposure to medications or toxins, were also considered as one of the possible precipitating factors. The association between his statin consumption and muscle weakness were not easily apparent at...
Source: Primary Care - January 23, 2023 Category: Primary Care Authors: Mercedes Malone Abdelilah Lahmar Atif Siddique Michael Rozboril Jesse L Kresak Source Type: research
Progressive proximal muscle weakness with subacute onset in an elderly patient: a case report
CONCLUSION: In this case, exclusion of inflammatory myopathies, metabolic muscle disorders and other neurological diseases is necessary for establishing a reliable diagnosis. In SINAM, simply discontinuing statin is often insufficient and aggressive immunosuppression or immunomodulation therapy is needed to achieve disease remission. This case aims to demonstrate that statins can induce serious muscular diseases that require aggressive immunosuppression.PMID:36544374 | DOI:10.33588/rn.7601.2021276
Source: Revista de Neurologia - December 22, 2022 Category: Neurology Authors: A Martins G Nadais M Pinto R Taipa L Costa S Pimenta Source Type: research
