Filtered By:
Vaccination: Tuberculosis (BCG) Vaccine
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 192 results found since Jan 2013.
BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity
Epidemiological studies and clinical trials suggest Bacillus Calmette-Guérin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce the severity of COVID-19. However, the mechanism by which BCG vaccination can induce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses is unknown. Here, we identify 8 novel BCG-derived peptides with significant sequence homology to either SARS-CoV-2 NSP3 or NSP13-derived peptides. Using an in vitro co-culture system, we show that human CD4+ ...
Source: Frontiers in Immunology - August 5, 2021 Category: Allergy & Immunology Source Type: research
The influence of leprosy-related clinical and epidemiological variables in the occurrence and severity of COVID-19: A prospective real-world cohort study
by Selma Regina Penha Silva Cerqueira, Patr ícia Duarte Deps, Débora Vilela Cunha, Natanael Victor Furtunato Bezerra, Daniel Holanda Barroso, Ana Bárbara Sapienza Pinheiro, Gecilmara Salviato Pillegi, Taynah Alves Rocha Repsold, Patrícia Shu Kurizky, Simon M. Collin, Ciro Martins Gomes
BackgroundProtective effects of Bacillus Calmette –Guérin (BCG) vaccination and clofazimine and dapsone treatment against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. Patients at risk for leprosy represent an interesting model for assessing the effects of these therapies on the occurrence ...
Source: PLoS Neglected Tropical Diseases - July 28, 2021 Category: Tropical Medicine Authors: Selma Regina Penha Silva Cerqueira Source Type: research
An update review of globally reported SARS-CoV-2 vaccines in preclinical and clinical stages
Int Immunopharmacol. 2021 Jul;96:107763. doi: 10.1016/j.intimp.2021.107763. Epub 2021 May 6.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the rapidly spreading pandemic COVID-19 in the world. As an effective therapeutic strategy is not introduced yet and the rapid genetic variations in the virus, there is an emerging necessity to design, evaluate and apply effective new vaccines. An acceptable vaccine must elicit both humoral and cellular immune responses, must have the least side effects and the storage and transport systems should be available and affordable for all countr...
Source: International Immunopharmacology - June 24, 2021 Category: Allergy & Immunology Authors: Hamid Motamedi Marzie Mahdizade Ari Shirin Dashtbin Matin Fathollahi Hadi Hossainpour Amirhoushang Alvandi Jale Moradi Ramin Abiri Source Type: research
Impact and projections of the COVID-19 epidemic on attendance and routine vaccinations at a pediatric referral hospital in Cameroon
CONCLUSION: The start of the COVID-19 pandemic was accompanied by a significant drop in consultation and vaccination activities. If no action is taken to correct this phenomenon, the ensuing months could be marked by a considerable increase in patients, sometimes suffering from vaccine-preventable diseases. The death rate could increase considerably in the pediatric population.PMID:34140219 | DOI:10.1016/j.arcped.2021.05.006
Source: Archives de Pediatrie - June 18, 2021 Category: Pediatrics Authors: D Chelo F Nguefack D Enyama R Nansseu G Feudjo Tefoueyet H D Mbassi Awa I Mekone Nkwelle G Nguefack-Tsague P Ndenbe P O Koki Ndombo Source Type: research
100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19
Nature Reviews Urology, Published online: 15 June 2021; doi:10.1038/s41585-021-00481-1Bacillus Calmette–Guérin (BCG) has been used to prevent tuberculosis for a century and is also a standard approach for the treatment of non-muscle-invasive bladder cancer. However, BCG also has a plethora of non-specific effects that occur via the induction of trained immunity and have raised the hypothesis that BCG vaccination could be used to protect against coronavirus disease 2019 (COVID-19). In this Perspective, the authors describe the history of BCG, discuss the mechanisms of its effects, and consider its potential role during t...
Source: Nature Reviews Urology - June 15, 2021 Category: Urology & Nephrology Authors: Niyati Lobo Nathan A. Brooks Alexandre R. Zlotta Jeffrey D. Cirillo Stephen Boorjian Peter C. Black Joshua J. Meeks Trinity J. Bivalacqua Paolo Gontero Gary D. Steinberg David McConkey Marko Babjuk J. Alfred Witjes Ashish M. Kamat Source Type: research
Animals are our overlooked allies in the fight against Covid | Melanie Challenger
It ’s important to recognise the vital role they’ve played in development of vaccines and treatmentsA few weeks ago, I received my first shot of a vaccine against Covid-19. As the newly vaccinated exited the clinic, there was a mix of relief and elation on people ’s faces. We exchanged little smiles of solidarity. If we could have burst into spontaneous applause, I’m sure we would have done.Recently, the lead scientist for the Oxford/AstraZeneca vaccine, Prof Sarah Gilbert,was honoured with the RSA Albert Medal. There are rumours that Gilbert ’s team, along with the pioneers of the mRNA vaccines, are up for a Nob...
Source: Guardian Unlimited Science - May 17, 2021 Category: Science Authors: Melanie Challenger Tags: Medical research Vaccines and immunisation Coronavirus Animals Science World news Source Type: news
Natural unblinding of BCG vaccination trials
Vaccine. 2021 Mar 17:S0264-410X(21)00320-0. doi: 10.1016/j.vaccine.2021.03.039. Online ahead of print.ABSTRACTThere is significant public and clinical interest in the potential for Bacillus Calmette-Guérin (BCG) vaccination to protect against type 2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) induced COVID-19. This question could be best answered by blinded and placebo controlled clinical trials. However, a skin reaction occurs within days at the site of BCG injection, making it rather challenging to blind this vaccination. Here, we examined registered clinical trials in ClinicalTrials.gov on BCG against CO...
Source: Vaccine - March 21, 2021 Category: Allergy & Immunology Authors: Reka Szigeti Richard Kellermayer Source Type: research
Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19
Gene. 2021 Mar 15;783:145574. doi: 10.1016/j.gene.2021.145574. Online ahead of print.ABSTRACTEpidemiological and clinical evidence suggests that Bacille Calmette-Guérin (BCG) vaccine induced trained immunity protects against non-specific infections. Multiple clinical trials are currently underway to assess effectiveness of the vaccine in the coronavirus disease 2019 (COVID-19). However, the durability and mechanism of BCG trained immunity remain unclear. Here, an integrative analysis of available epidemiological transcriptomic data related to BCG vaccination and respiratory tract viral infections as well as of reported tr...
Source: Gene - March 19, 2021 Category: Genetics & Stem Cells Authors: Abhay Sharma Source Type: research
The BCG Vaccine for COVID-19: First Verdict and Future Directions
Despite of the rapid development of the vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses and the proper infrastructure to vaccinate a good proportion of the world population. In this interim, the accessibility to the Bacille Calmette-Guerin (BCG) may mitigate the pandemic impact in some countries and the BCG vaccine offers significant advantages and flexibility in the way clinical vaccines are administered. BCG vaccination is a highly cost-effective intervention against tuberculosis (TB) and many low-and lower-middle-income countries would l...
Source: Frontiers in Immunology - March 8, 2021 Category: Allergy & Immunology Source Type: research
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
