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Therapy: Statin Therapy
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Total 407 results found since Jan 2013.
Brain Leukocytes as the Potential Therapeutic Target for Post-COVID-19 Brain Fog
Neurochem Res. 2023 Mar 23:1-5. doi: 10.1007/s11064-023-03912-0. Online ahead of print.ABSTRACTAfter recovering from the acute phase of coronavirus disease 2019 (COVID-19), many patients struggle with additional symptoms of long COVID during the chronic phase. Among them, the neuropsychiatric manifestations characterized by a short-term memory loss and inability to concentrate are called "brain fog". Recent studies have revealed the involvement of "chronic neuro-inflammation" in the pathogenesis of brain fog following COVID-19 infection. In the COVID-related brain fog, similarly to neurodegenerative disorders caused by neu...
Source: Neurochemical Research - March 23, 2023 Category: Neuroscience Authors: Itsuro Kazama Source Type: research
Impact of In-hospital Statin Use on Mortality in COVID-19 Patients from a Majority African American Population
Coronavirus Disease 2019 (COVID-19) was declared a worldwide pandemic by the World Health Organization on March 11, 2020.1 As of August 18th, 2022, the pandemic has claimed over 6,400,000 lives worldwide and over 1,000,000 lives in the United States according to the Johns Hopkins Coronavirus Resource Center.2 The virus works primarily by binding to angiotensin-converting receptor 2 on alveolar epithelial cells, whereby it activates the innate and adaptive immune systems and results in inflammation caused by a pro-inflammatory cytokine storm.
Source: Heart and Lung - March 12, 2023 Category: Intensive Care Authors: Nitish Sood, Dhairya Shukla, Pranjal Mishra, Saloni Sharma, Sahil Gandhi, Daniel F. Linder, Priyank Shah Source Type: research
The Effects of Statins on Respiratory Symptoms and Pulmonary Fibrosis in COVID-19 Patients with Diabetes Mellitus: A Longitudinal Multicenter Study
AbstractThe aim of this prospective cohort study was to explore the effect of statins on long-term respiratory symptoms and pulmonary fibrosis in coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM). Patients were recruited from three tertiary hospitals, categorized into Statin or Non-statin groups, and assessed on days 0, 28, and 90 after symptoms onset to record the duration of symptoms. Pulmonary fibrosis was scored at baseline and follow-up time points by high-resolution computed tomography scans. Each group comprised 176 patients after propensity score matching. Data analysis revealed that the odds...
Source: Archivum Immunologiae et Therapiae Experimentalis - February 28, 2023 Category: Allergy & Immunology Source Type: research
Association of statin use with outcomes of patients admitted with COVID-19: an analysis of electronic health records using superlearner
Statin use prior to hospitalization for Coronavirus Disease 2019 (COVID-19) is hypothesized to improve inpatient outcomes including mortality, but prior findings from large observational studies have been inco...
Source: BMC Infectious Diseases - February 24, 2023 Category: Infectious Diseases Authors: Adovich S. Rivera, Omar Al-Heeti, Lucia C. Petito, Mathew J. Feinstein, Chad J. Achenbach, Janna Williams and Babafemi Taiwo Tags: Research Source Type: research
Early Experience with Modified Dose Nirmatrelvir/Ritonavir in Dialysis Patients with Coronavirus Disease 2019
CONCLUSIONS: A modified dose of nirmatrelvir/ritonavir use was found to be safe and well tolerated in terms of no serious adverse events being observed in a small sample of maintenance dialysis patients.PMID:36723285 | DOI:10.2215/CJN.0000000000000107
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 1, 2023 Category: Urology & Nephrology Authors: Swapnil Hiremath Peter G Blake Angie Yeung Michaeline McGuinty Doneal Thomas Jane Ip Pierre Antoine Brown Michael Pandes Andrew Burke Qazi Zain Sohail Karen To Lindsay Blackwell Matthew Oliver Arsh K Jain Zain Chagla Rebecca Cooper Source Type: research
Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.
Communication Between Blood and Brain in Aging and Rejuvenation
https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/
As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inter...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SARS-CoV-2 infection and SLE: endothelial dysfunction, atherosclerosis, and thrombosis
We present systemic lupus erythematosus (SLE) as a model rheumatic disease with endothelial dysfunction and discuss its mechanisms, factors that influence the early onset and rapid progression of atherosclerosis, and the increased risk of thromboembolic events. We focus on established methods to improve endothelium function, including statins, antiplatelet, and antithrombotic therapy. Hypercoagulable and hypofibrinolitic states and a hyperinflammatory response characterize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathogenic mechanisms are typical for an acute phase of Covid-19 post-Co...
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Wojciech P łazak Leszek Drabik Source Type: research
Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir
Yakugaku Zasshi. 2022;142(10):1125-1127. doi: 10.1248/yakushi.22-00099.ABSTRACTA 55-year-old man with hypertrophic cardiomyopathy and a pacemaker was admitted with coronavirus disease 2019 (COVID-19). Before admission, the patient's medications included amiodarone, diltiazem, bisoprolol, atorvastatin, etizolam, and warfarin (WF). After admission, dexamethasone (DXM) and remdesivir (RDV) were initiated for treating COVID-19. The international normalized ratio (INR) on admission was 1.8, which increased to 3.4 on day 5 and to 6.9 on day 10 after admission. Although there have been reports that RDV may occasionally prolong pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Hidetoshi Ishii Norio Yokota Yuki Bando Katsuya Otori Source Type: research
