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Therapy: Statin Therapy

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Total 407 results found since Jan 2013.

HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study
ConclusionsStatin treatment had a modest negative association with COVID-19 mortality. While this finding needs confirmation from randomized clinical trials, it supports the continued use of statin treatment for medical prevention according to current recommendations also during the COVID-19 pandemic.
Source: PLoS Medicine - October 14, 2021 Category: Internal Medicine Authors: Rita Bergqvist Source Type: research

All-cause mortality in COVID-19 patients receiving statin therapy: analysis of veterans affairs database cohort study
AbstractStatins have been advocated as a potential treatment for coronavirus disease-2019 (COVID-19) due to its pleotropic properties. The aim of the study was to elucidate the association between antecedent statin exposure and 30-day all-cause mortality, intensive care unit (ICU) admission and hypoxic respiratory failure requiring mechanical ventilation in patients diagnosed with COVID-19. Observational cohort study derived from the VA Corporate Data Warehouse of all veterans tested positive for COVID-19 between January 1st and May 31st, 2020. Antecedent use of statins was defined as a redeemed drug prescription in the 6 ...
Source: Internal and Emergency Medicine - October 12, 2021 Category: Emergency Medicine Source Type: research

Pharmacologic Treatments for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome is a heterogenous syndrome with many etiologies for which there are no definitive pharmacologic treatments, despite decades of research. We explore some adjunctive pharmacologic therapies, including neuromuscular blockade, corticosteroids, and inhaled pulmonary vasodilators. Additionally, we explore some investigative therapies, including Vitamin C, beta-agonists, statins, mesenchymal stromal cells, and granulocyte –macrophage colony stimulating factor. We do discuss the potential role of steroids in acute respiratory distress syndrome with severe acute respiratory syndrome coronavirus...
Source: Critical Care Clinics - September 19, 2021 Category: Intensive Care Authors: Nida Qadir, Steven Y. Chang Source Type: research

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis
Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unknown. To determine the molecular mechanism of multiple organ dysfunction, a bioinformatics analysis method based on a time-order gene co-expression network (TO-GCN) was performed. First, gene expression profiles were downloaded from the gene expression omnibus database (GSE161200), and a TO-GCN was constructed using the breadth-first search (BFS) algorithm to infer the pattern of changes in...
Source: Frontiers in Immunology - August 24, 2021 Category: Allergy & Immunology Source Type: research

Sex Differences in Association Between Anti-Hypertensive Medications and Risk of COVID-19 in Middle-Aged and Older  Adults
ConclusionsThe study suggested sex differences in the risk of death from COVID-19 with the use of ACEI and ARB among middle-aged and older adults. Sex differences in the risk of hospitalization for COVID-19 with the use of CCB was observed as well. It is of clinical importance that clinicians adopt different CVD treatment approaches for female and male patients with COVID-19.
Source: Drugs and Aging - August 18, 2021 Category: Geriatrics Source Type: research

Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147  824 patients
The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory coronavirus  2 (SARS-CoV-2), remains a major public health problem across the globe, despite the availability of vaccines (Hamed et al., 2021). Consequently, there is a continuing need for effective pharmacological therapies that reduce the morbidity and mortality of patients with COVID-19.
Source: International Journal of Infectious Diseases - August 6, 2021 Category: Infectious Diseases Authors: Carlos Diaz-Arocutipa, Beatriz Melgar-Talavera, Ángel Alvarado-Yarasca, María M. Saravia-Bartra, Pedro Cazorla, Iván Belzusarri, Adrian V. Hernandez Source Type: research

Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147,824 patients
The current coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory coronavirus-2 (SARS-CoV-2), remains a major public health problem across the globe, despite the availability of vaccines (Hamed et al., 2021). In the meantime, we continue to need effective pharmacological therapies that reduce the morbidity and mortality of patients with COVID-19.
Source: International Journal of Infectious Diseases - August 6, 2021 Category: Infectious Diseases Authors: Carlos Diaz-Arocutipa, Beatriz Melgar-Talavera, Ángel Alvarado-Yarasca, María M. Saravia-Bartra, Pedro Cazorla, Iván Belzusarri, Adrian V. Hernandez Source Type: research

The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis
ConclusionStatin use is associated with a better prognosis in patients with COVID-19. Our findings provide a rationale to investigate the use of statins among patients with COVID-19 in large scale clinical  trials.
Source: American Journal of Cardiovascular Drugs - August 3, 2021 Category: Cardiology Source Type: research

The impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidence
Purpose of review Coronavirus Disease 2019 (COVID19) has caused significant global morbidity and mortality, especially in persons with underlying cardiovascular disease. There have been concerns that lipid-lowering therapy (LLT) increases angiotensin-converting enzyme 2 levels. Conversely, pleiotropic effects of statins can theoretically protect against severe COVID19 infection, supporting evidence from other respiratory illnesses in which statin use probably confers benefit. Recent findings There is an abundance of studies that show that statins are safe and potentially protect against severe COVID19 infection ...
Source: Current Opinion in Lipidology - July 14, 2021 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19): reconsideration is needed
Publication date: Available online 5 July 2021Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Jeremy Rafael Tandaju, Wang Ii, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi
Source: Nutrition, Metabolism and Cardiovascular Diseases - July 5, 2021 Category: Nutrition Source Type: research

Preadmission Statin Therapy and Clinical Outcome in Hospitalized Patients With COVID-19: An Italian Multicenter Observational Study
Abstract: Statin therapy has been recently suggested as possible adjuvant treatment to improve the clinical outcome in patients with coronavirus disease 2019 (COVID-19). The aim of this study was to describe the prevalence of preadmission statin therapy in hospitalized patients with COVID-19 and to investigate its potential association with acute distress respiratory syndrome (ARDS) at admission and in-hospital mortality. We retrospectively recruited 467 patients with laboratory-confirmed COVID-19 admitted to the emergency department of 10 Italian hospitals. The study population was divided in 2 groups according to the...
Source: Journal of Cardiovascular Pharmacology - July 1, 2021 Category: Cardiology Tags: Original Article Source Type: research

Authors’ response: Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19)
Publication date: Available online 29 June 2021Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Timotius Ivan Hariyanto, Andree Kurniawan
Source: Nutrition, Metabolism and Cardiovascular Diseases - June 29, 2021 Category: Nutrition Source Type: research

Authors ’ response: Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 28, 2021 Category: Nutrition Authors: Timotius Ivan Hariyanto, Andree Kurniawan Tags: Letters to the Editor Source Type: research