Filtered By:
Therapy: Immunotherapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 743 results found since Jan 2013.
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research
Acute motor-sensory axonal polyneuropathy variant of Guillain-Barr é syndrome with a thalamic lesion and COVID-19: a case report and discussion on mechanism
ConclusionThe AMSAN variant of GBS secondary to COVID-19 infection is severe and can cause extensive damage to the peripheral nerves system. The deterioration of symptoms in the patient after early immunotherapy may indicate treatment-related fluctuation (TRF) and could be attributed to immune rebound. Moreover, an excessive immune response post-COVID-19 infection may trigger concurrent damage to the central nervous system, indicating secondary harm to brain small blood vessels and nerve units. For suspected cases of GBS complicated by COVID-19, it is essential to conduct early brain MRI examinations in addition to routine...
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
COVID-19 vaccination is associated with enhanced efficacy of anti-PD-(L)1 immunotherapy in advanced NSCLC patients: a real-world study
Coronavirus disease 2019 (COVID-19) vaccine has played a major role in ending the pandemic. However, little is known about the influence of COVID-19 vaccine on the efficacy of immunotherapy in patients with no...
Source: Infectious Agents and Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Yunfei Qian, Zhuxian Zhu, Yin-Yuan Mo and Ziqiang Zhang Tags: Research Source Type: research
Spike Protein is a key target for stronger and more persistent T-Cell Responses – A study of mild and asymptomatic SARS-CoV-2 Infection.
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus led to devastating consequences, with over 768,983,095 confirmed cases and 6,953,743 million deaths reported as of 26th July 2023 (WHO, 2023 https://covid19.who.int/). Highlighting the critical importance of both T-cell and antibody responses is imperative for effectively addressing the complexities posed by COVID-19. Amidst the significant antibody research, there's a growing realisation that understanding and leveraging T-cell responses is pivotal for designing efficacious SARS-CoV-2 vaccines ...
Source: International Journal of Infectious Diseases - September 6, 2023 Category: Infectious Diseases Authors: Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, The COVID-19 Immunoprofiling Team, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christophe Source Type: research
Bioinformatics analysis of carotid vulnerable plaques associated with the SARS-CoV-2 Pattern
Gene. 2023 Aug 31:147754. doi: 10.1016/j.gene.2023.147754. Online ahead of print.ABSTRACTThe rupture of carotid artery vulnerable plaque plays a critical role in ischemic stroke, and the widely spread new coronavirus in recent years plays a certain role in the development of human carotid artery vulnerable plaque, we screened out 27 differential expression genes (DEGs) of stable plaque and vulnerable plaque associated with the new coronavirus. Through the construction of the protein-protein interaction (PPI) network, the Cathepsin B (CTSB) and Niemann-Pick Disease Type 2 (NPC2) were identified as crucial expression genes, ...
Source: Gene - September 2, 2023 Category: Genetics & Stem Cells Authors: Tao Jiang Jiaming Huang Shupeng Li Qiushi Xu Tianding Zhang Xianwei Wang Dong Chen Source Type: research
The Important Role of Interleukin-2 in COVID-19
J Immunol Res. 2023 Aug 22;2023:7097329. doi: 10.1155/2023/7097329. eCollection 2023.ABSTRACTThere is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables. The...
Source: Journal of Immunology Research - August 31, 2023 Category: Allergy & Immunology Authors: Leila Ghanbari Naeini Laleh Abbasi Farzaneh Karimi Pajman Kokabian Fahimeh Abdi Abyaneh Delaram Naderi Source Type: research
Radiological assessment of immunotherapy effects and immune checkpoint-related pneumonitis for lung cancer
This article reviews the complications of immunotherapy in lung cancer and illustrates various radiologic patterns of ICI-pneumonitis. Additionally, it is tried to differentiate ICI-pneumonitis from other pulmonary pathologies common to lung cancer such as radiation pneumonitis, bacterial pneumonia and coronavirus disease of 2019 (COVID-19) infection in recent months. Maybe it is challenging to distinguish radiologically but clinical presentation may help.PMID:37525480 | DOI:10.1111/jcmm.17895
Source: Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Qiongjie Hu Shaofang Wang Li Ma Ziyan Sun Zilin Liu Shuang Deng Jianlin Zhou Source Type: research
