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Total 11695 results found since Jan 2013.
First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.PMID:37676147 | PMC:PMC10486197 | DOI:10.2807/1560-7917.ES.2023.28.36.2300460
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Morten Rasmussen Frederik Trier M øller Vithiagaran Gunalan Sharmin Baig Marc Bennedb æk Lasse Engbo Christiansen Arieh Sierra Cohen Kirsten Ellegaard Anders Fomsgaard Kristina Tr æholt Franck Nicolai Balle Larsen Tine Graakj ær Larsen Ria Lassauni è Source Type: research
Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer
iScience. 2023 Aug 15;26(9):107648. doi: 10.1016/j.isci.2023.107648. eCollection 2023 Sep 15.ABSTRACTAntibody-dependent cellular cytotoxicity (ADCC) is associated with protection against neonatal herpes. We hypothesized that placental transfer of ADCC-mediating herpes simplex virus (HSV) immunoglobulin G (IgG) is influenced by antigenic target, function, glycans, gestational age, and maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Maternal and cord blood were collected from HSV-seropositive (HSV+) mothers pre-COVID and HSV+/SARS-CoV-2+ mothers during the pandemic. Transfer of HSV neutralizi...
Source: Herpes - September 6, 2023 Category: Infectious Diseases Authors: Aakash Mahant Mahant Fatima Estrada Trejo Jennifer T Aguilan Simone Sidoli Sallie R Permar Betsy C Herold Source Type: research
Spike Protein is a key target for stronger and more persistent T-Cell Responses – A study of mild and asymptomatic SARS-CoV-2 Infection.
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus led to devastating consequences, with over 768,983,095 confirmed cases and 6,953,743 million deaths reported as of 26th July 2023 (WHO, 2023 https://covid19.who.int/). Highlighting the critical importance of both T-cell and antibody responses is imperative for effectively addressing the complexities posed by COVID-19. Amidst the significant antibody research, there's a growing realisation that understanding and leveraging T-cell responses is pivotal for designing efficacious SARS-CoV-2 vaccines ...
Source: International Journal of Infectious Diseases - September 6, 2023 Category: Infectious Diseases Authors: Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, The COVID-19 Immunoprofiling Team, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christophe Source Type: research
Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection
Repeated coronavirus infections in childhood drive progressive maturation of systemic immune responses into adulthood. Analyses of immune responses in children have focused primarily upon systemic assessment but the importance of mucosal immunity is increasingly recognised. We studied virus-specific antibody responses in contemporaneous nasal swab and blood samples from 99 children (4-15 years) and 28 adults (22-56 years), all of whom had prior SARS-CoV-2 infection. Whilst mucosal IgA titres against Influenza and Respiratory Syncytial virus were comparable between children and adults, those against all coronaviruses, inclu...
Source: Journal of Infection - September 1, 2023 Category: Infectious Diseases Authors: Alexander C. Dowell, Gokhan Tut, Jusnara Begum, Rachel Bruton, Christopher Bentley, Megan Butler, Grace Uwenedi, Jianmin Zuo, Annabel A. Powell, Andrew J. Brent, Bernadette Brent, Frances Baawuah, Ifeanyichukwu Okike, Joanne Beckmann, Shazaad Ahmad, Felic Source Type: research
Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in COVID-19 patients
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus and the cause of coronavirus disease 2019 (COVID-19), a highly infectious respiratory illness characterized by fever, coughing, sore throat, fatigue, headache, muscle pain, and hemoptysis [1-3]. There has been an increased attention to otologic symptoms in COVID-19 patients [4, 5]. Upper respiratory tract infections often result in middle ear infections, although there is limited evidence of a causal relationship of COVID-19 and otitis media with effusions (OME) [6].
Source: International Journal of Infectious Diseases - August 31, 2023 Category: Infectious Diseases Authors: Yue Fan, Ruzhen Gao, Yingying Shang, Xu Tian, Yang Zhao, Xingming Chen Source Type: research
Association between cyclin-dependent kinase inhibitor 2B antisense RNA 1 and zinc finger homeobox 3 gene polymorphisms and COVID-19 severity
There is no doubt about the cardiovascular complications of coronavirus disease 2019 (COVID-19). Several genetic studies have demonstrated an association between genetic variants in a region on chromosome 9p21...
Source: BMC Infectious Diseases - August 31, 2023 Category: Infectious Diseases Authors: Eman A. Badr, Nesreen G. Elhelbawy, Alaa Osama Nagy, Amany A. Sultan and Shereen S. Elnaidany Tags: Research Source Type: research
Could ischemia-modified albumin levels predict the severity of disease in SARS-CoV-2 infection?
Conclusions: We analyzed a sample of patients with COVID-19 infection and found that IMA predicted severe COVID-19 disease. Disease severity grouping was based on patients ' clinical and radiological features. IMA level measured when SARS-CoV-2 infection is diagnosed may be a useful marker in predicting likely disease severity or intensive care need.
Source: The Journal of Infection in Developing Countries - August 30, 2023 Category: Infectious Diseases Authors: Mustafa Tanr ıverdi, Nevhiz Gündoğdu, Necla Benlier, Mustafa Yıldırım, Hale Çeliktürk, Hanifi Ayhan Özkur, Pınar Günel Karadeniz, Gülşen Özkan Tanrıverdi, Hülya Çiçek Source Type: research
Computed tomography findings in COVID-19 and atypical pneumonia: a comparative study
Conclusions: There were significant differences between the CT patterns of patients with COVID-19 and other atypical pneumonia. The presence of patchy consolidations, GGO, crazy paving patterns with typical peripheral, bilateral distribution, and absence of centrilobular nodules, pleural effusion, and multifocal consolidations may help to differentiate COVID-19 from atypical pneumonia.
Source: The Journal of Infection in Developing Countries - August 30, 2023 Category: Infectious Diseases Authors: Esra Çıvgın, İzzet Selçuk Parlak, Yasin Celal Güneş, Gülsüm Kübra Bahadır, Ayşegül Karalezli Source Type: research
Could ischemia-modified albumin levels predict the severity of disease in SARS-CoV-2 infection?
Conclusions: We analyzed a sample of patients with COVID-19 infection and found that IMA predicted severe COVID-19 disease. Disease severity grouping was based on patients ' clinical and radiological features. IMA level measured when SARS-CoV-2 infection is diagnosed may be a useful marker in predicting likely disease severity or intensive care need.
Source: The Journal of Infection in Developing Countries - August 30, 2023 Category: Infectious Diseases Authors: Mustafa Tanr ıverdi, Nevhiz Gündoğdu, Necla Benlier, Mustafa Yıldırım, Hale Çeliktürk, Hanifi Ayhan Özkur, Pınar Günel Karadeniz, Gülşen Özkan Tanrıverdi, Hülya Çiçek Source Type: research
Computed tomography findings in COVID-19 and atypical pneumonia: a comparative study
Conclusions: There were significant differences between the CT patterns of patients with COVID-19 and other atypical pneumonia. The presence of patchy consolidations, GGO, crazy paving patterns with typical peripheral, bilateral distribution, and absence of centrilobular nodules, pleural effusion, and multifocal consolidations may help to differentiate COVID-19 from atypical pneumonia.
Source: The Journal of Infection in Developing Countries - August 30, 2023 Category: Infectious Diseases Authors: Esra Çıvgın, İzzet Selçuk Parlak, Yasin Celal Güneş, Gülsüm Kübra Bahadır, Ayşegül Karalezli Source Type: research
Biochemical, Serological and Immunological Tests for Diagnosis of Coronavirus Disease 2019 (COVID-19) Patients: A Comprehensive Systematic Review and Meta-analysis
CONCLUSION: The results show lymphopenia, elevated ESR level, elevated CRP level, elevated serum amyloid-A, elevated TNFα, elevated procalcitonin level, elevated interleukin-6 level, reduced CD3, reduced CD4, elevated BNP, elevated LDH, reduced albumin, reduced pre-albumin, and elevated Ddimer levels as the most common findings at the time of admission.PMID:37646320 | DOI:10.2174/1871526523666230228144910
Source: Infectious Disorders Drug Targets - August 30, 2023 Category: Infectious Diseases Authors: Milad Azami Amirreza Jamshidbeigi Hadi Esmaeili Gouvarchin Ghaleh Reza Ranjbar Source Type: research
Arbidol: The current demand, strategies, and antiviral mechanisms
CONCLUSION: ARB is a broad-spectrum antiviral drug that inhibits several viruses in vivo and in vitro, with high safety profile and low resistance; the antiviral mechanisms of ARB deserve to be further explored and more high-quality clinical studies are required to establish the efficacy and safety of ARB.PMID:37647451 | DOI:10.1002/iid3.984
Source: Herpes - August 30, 2023 Category: Infectious Diseases Authors: Yue Kang Yin Shi Silu Xu Source Type: research
