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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
A randomized trial to evaluate the preventive effect of lafutidine on chemotherapy-induced peripheral neuropathy in patients treated with carboplatin and paclitaxel for lung cancer
CONCLUSIONS: Although the preventive effect of lafutidine on CIPN could not be demonstrated statistically, lafutidine FACT/GOG-Ntx scores showed a trend toward decreased neurotoxicity as chemotherapy proceeded. More reliable studies using lafutidine on the prevention of CIPN should be conducted.TRIAL REGISTRATION: Japan Registry of Clinical Trials identifier: jRCTs021200031.PMID:37731302 | DOI:10.21037/apm-23-90
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Katsuya Cho Hirotaka Saikawa Tatsuya Hashimoto Hiroshi Katagiri Yoshihiro Owada Kazuhiro Yakuwa Itaru Fujimura Yu Utsumi Masachika Akiyama Hiromi Nagashima Fumiaki Takahashi Makoto Maemondo Source Type: research
A Review on the Antimutagenic and Anticancer Effects of Cysteamine
In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.PMID:37731680 | PMC:PMC10508993 | DOI:10.1155/2023/2419444
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Chun-Man Lee Source Type: research
Site-specific delivery of cisplatin and paclitaxel mediated by liposomes: A promising approach in cancer chemotherapy
Environ Res. 2023 Sep 19:117111. doi: 10.1016/j.envres.2023.117111. Online ahead of print.ABSTRACTThe site-specific delivery of drugs, especially anti-cancer drugs has been an interesting field for researchers and the reason is low accumulation of cytotoxic drugs in cancer cells. Although combination cancer therapy has been beneficial in providing cancer drug sensitivity, targeted delivery of drugs appears to be more efficient. One of the safe, biocompatible and efficient nano-scale delivery systems in anti-cancer drug delivery is liposomes. Their particle size is small and they have other properties such as adjustable phy...
Source: Environmental Research - September 21, 2023 Category: Environmental Health Authors: Jianyong Zou Source Type: research
Shrinking the Battlefield in Cancer Therapy: Nanotechnology Against Cancer Stem Cells
In conclusion, nanotechnology presents a novel, powerful tool in the fight against cancer, particularly in targeting the elusive and treatment-resistant CSCs. This comprehensive review delves into the intricacies of nanotherapy, explicitly targeting cancer stem cells, their markers, and associated signaling pathways.PMID:37729956 | DOI:10.1016/j.ejps.2023.106586
Source: European Journal of Pharmaceutical Sciences - September 20, 2023 Category: Drugs & Pharmacology Authors: Queenie Fernandes Lubna Therachiyil Abdul Q Khan Takwa Bedhiafi Hesham M Korashy Ajaz A Bhat Shahab Uddin Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
A CaCO < sub > 3 < /sub > -based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy
CONCLUSION: Accordingly, the potential of QD@Ca/ML-Arg-was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.PMID:37729741 | DOI:10.1016/j.tranon.2023.101771
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jiale Cai Guiping Hu Lihua Hu Junge Chen Dan Chen Dan Liu Xiaolei Wang Boxian Hu Cheng Li Source Type: research
Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19
CONCLUSION: the quality of life of the sample was low; there is a correlation between quality of life and financial toxicity, although not significant. The higher the financial toxicity, the lower the quality of life.PMID:37729248 | DOI:10.1590/1518-8345.6688.3995
Source: Revista Latino-Americana de Enfermagem - September 20, 2023 Category: Nursing Authors: Nat ália Naome Oshiro Luciana de Alcantara Nogueira Yasmin Hiorrana Dos Santos Paulo Ricardo Bittencourt Guimar ães Luciana Puchalski Kalinke Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
A CaCO < sub > 3 < /sub > -based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy
CONCLUSION: Accordingly, the potential of QD@Ca/ML-Arg-was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.PMID:37729741 | DOI:10.1016/j.tranon.2023.101771
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jiale Cai Guiping Hu Lihua Hu Junge Chen Dan Chen Dan Liu Xiaolei Wang Boxian Hu Cheng Li Source Type: research
Personalized neoantigen cancer vaccines: An analysis of the clinical and commercial potential of ongoing development programs
Drug Discov Today. 2023 Sep 18:103773. doi: 10.1016/j.drudis.2023.103773. Online ahead of print.ABSTRACTNeoantigen cancer vaccines harbor promise as next-generation immuno-oncology therapies, whereby cancer vaccines are tailored to the patient's tumor antigen and represent the future of personalized cancer therapy. While several biotech companies have ongoing development programs, little has been published about the true commercial potential of these innovative therapies and the challenges these products will face upon regulatory approval. In this paper, we provide an overview of neoantigen cancer vaccine development progr...
Source: Drug Discovery Today - September 20, 2023 Category: Drugs & Pharmacology Authors: Maurice Perrinjaquet C Richard Schlegel Source Type: research
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models
We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer(mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, conferred sensitivity and were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive(ARPC) prostate cancer models, even with low B7H3 l...
Source: Clinical Prostate Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Supreet Agarwal Lei Fang Kerry McGowen JuanJuan Yin Joel Bowman Anson T Ku Aian Neil Alilin Eva Corey Martine P Roudier Lawrence D True Ruth F Dumpit Ilsa Coleman John K Lee Peter S Nelson Brian J Capaldo Aida Mariani Clare E Hoover Ilya S Senatorov Micha Source Type: research
Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach
CONCLUSION: The target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1-4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments.PMID:37726449 | DOI:10.1007/s10549-023-07107-7
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nivruthi Shekar Paton Vuong Parwinder Kaur Source Type: research
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Nanoscale. 2023 Sep 19. doi: 10.1039/d3nr02816j. Online ahead of print.ABSTRACTLocalized heat generation from manganese iron oxide nanoparticles (MIONPs) conjugated with chemotherapeutics under the exposure of an alternating magnetic field (magneto-chemotherapy) can revolutionize targeted breast cancer therapy. On the other hand, the lack of precise control of local temperature and adequate MIONP distribution in laboratory settings using the conventional two-dimensional (2D) cellular models has limited its further translation in tumor sites. Our current study explored advanced 3D in vitro tumor models as a promising altern...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Satish S Phalake Sandeep B Somvanshi Syed A M Tofail Nanasaheb D Thorat Vishwajeet M Khot Source Type: research
Qualitative study of Oncology Clinicians' Perceptions of Barriers to Offering Clinical Trials to Underserved Populations
CONCLUSION: Findings reveal multi-level barriers to offering cancer clinical trials to underrepresented patients. Targeted solutions, including system level changes to support clinicians, patient financial support, and implementation of clinical trial navigation programs were recommended to help reduce access barriers and increase enrollment of underrepresented patients into cancer clinical trials.PMID:37724824 | DOI:10.1177/10732748231187829
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Giselle K Perez Anjali R Oberoi Lucy Finkelstein-Fox Elyse R Park Ryan D Nipp Beverly Moy Source Type: research
