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Specialty: Molecular Biology
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Total 131552 results found since Jan 2013.
Transcriptomic Analysis in Renal Cell Carcinoma and COVID-19 patients
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):156-162. doi: 10.14715/cmb/2023.69.8.24.ABSTRACTCOVID-19 pandemic poses a heavy risk upon global public health. The disease's severity and infection rate are high, especially among cancer patients. The current research was conducted to identify the most common biological pathways and how far they are associated with COVID-19 infection and clear cell renal cell carcinoma. In the current study, the authors analyzed the differentially expressed genes from the experimental and control groups with the help of the GEO2R tool. The study analyzed the protein-protein interactions th...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maha Abdulla Alwaili Source Type: research
Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):163-171. doi: 10.14715/cmb/2023.69.8.25.ABSTRACTVarious research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon sam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Dalal S Alshaya Tahani Mohamed Ibrahim Al-Hazani Mashael Alhumaidi Alotaibi Dalia Mostafa Domiaty Eman Alshehri Maha Abdulla Alwaili Amani Mohammed Alotaibi Areej Saud Jalal Alaa Ali AlQahtani Fatima Abdullah AlQassim Gadah Albasher Wedad Saeed Al-Qahtani Source Type: research
Circ_KATNAL1 promotes the inflammation and apoptosis in human middle ear epithelial cells induced by lipopolysaccharide by regulating the miR-153-3p / TLR4 axis
In conclusion, circ_KATNAL1 can promote an inflammatory role in human middle ear epithelial cells through the miR- 31-5p / TLR4 axis, which may become an important target for the diagnosis and treatment of otitis media.PMID:37715400 | DOI:10.14715/cmb/2023.69.8.26
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Siquan Guo Feng Qin Jiang Wang Yongqing Ding Haixiang Xue Jianqiang You Changjiang Chao Source Type: research
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
High glucose-induced imbalance of mitochondria-associated ER membranes function promotes RSC96 cell damage
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):138-142. doi: 10.14715/cmb/2023.69.7.22.ABSTRACTTo investigate the effect of high glucose on mitochondrial-related ER membranes (MAMs) in rat Schwann cells (SCs) and the mechanism of cell injury. SCs (RSC96) cells were used as the control group, and RSC96 cells cultured in a high glucose environment for 48 h were set as the experimental group. The level of intracellular calcium was observed by flow cytometry, and ROS levels were detected by DCFH-DA fluorescent probe. The subcellular structure was observed by transmission electron microscopy, focusing on the morphology of mi...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Housheng Fu Jianbing Xu Fei Wang Weifu Wang Zhongyao Wang Source Type: research
Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus Infection
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):168-173. doi: 10.14715/cmb/2023.69.7.27.ABSTRACTChronic active EBV infection (CAEBV) is associated with poor prognosis and high mortality. We performed bioinformatics analysis to screen out key genes associated with CAEBV. Weighted gene co-expression network analysis (WGCNA) was used to identify the gene module which was most correlated with pediatric CAEBV. Furthermore, the differentially expressed genes (DEGs) between pediatric acute infectious mononucleosis (AIM) and pediatric CAEBV were investigated. Least absolute shrinkage and selection operator (LASSO) and random for...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yi Zhang Wenli Liu Yue Li Xiaoyu An Dandan Zhao Source Type: research
Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis
This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Coun...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lemeng Chang Chunhua Xie Kaiping Chou Qingnan Meng Lihui Zhao Source Type: research
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
Mol Cell Proteomics. 2023 Sep 14:100647. doi: 10.1016/j.mcpro.2023.100647. Online ahead of print.ABSTRACTThe NFE2L2(NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry (MS)-based targeted proteomics assay based on internal standard triggered parallel reaction monitoring (IS-PRM) to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical si...
Source: Molecular and Cellular Proteomics : MCP - September 16, 2023 Category: Molecular Biology Authors: Nathan T Wamsley Emily M Wilkerson Li Guan Kyle M LaPak Travis P Schrank Brittany J Holmes Robert W Sprung Petra Erdmann Gilmore Sophie P Gerndt Ryan S Jackson Randal C Paniello Patrik Pipkorn Sidharth V Puram Jason T Rich Reid R Townsend Jos é P Zevallo Source Type: research
Bioinformatics-based analysis of core genes and pathway enrichment in early diabetic nephropathy
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):51-56. doi: 10.14715/cmb/2023.69.7.9.ABSTRACTDiabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD). Bioinformatics technology was adopted to screen and analyze the core genes of early DN to explore its pathogenesis. GSE30528, GSE96804, and GSE30122 chip data were obtained from Gene Expression Omnibus (GEO) database to screen DN and healthy controls for differentially expressed genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) for functional annotation and signaling pathway enrichment; String and Cytoscape were used for protein...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Yangwenxuan Han Xiaoyan Liu Jing Shang Na Li Chunjian Zhang Ying Li Jiaxin Zheng Source Type: research
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):57-65. doi: 10.14715/cmb/2023.69.7.10.ABSTRACTObesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glycerides and free fatty acids. Due to unsatisfactory results and severe side effects of the current drugs available for treating obesity, there is an urgent need to identify novel therapeutic options. Boerhaavia diffusa is one of the widely known species of flowering plant commonly known as Punam...
Source: Molecular Medicine - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Sirajuddin Anwar Chettupalli Ananda K Nasrin E Khalifa Weam M A Khojali Mhdia E Osman Kareem M Younes Amr S Abouzied Suresh B Jandrajupalli Swarnalatha Chandolu Source Type: research
Knocking down SOX2 overcomes the resistance of prostate cancer to castration via notch signaling
CONCLUSION: We demonstrated that SOX2/Notch signaling was responsible for Enzalutamide resistance in CRPC. Targeting SOX2/Notch signaling might represent a new choice for the treatment and therapy of CRPC.PMID:37716921 | DOI:10.1007/s11033-023-08757-y
Source: Molecular Biology Reports - September 16, 2023 Category: Molecular Biology Authors: Zhongbo Du Xiaobin Chen Pingyu Zhu Qi Lv Jun Yong Junqing Gu Source Type: research
Serum long noncoding RNA H19/micro RNA-675-5p axis as a probable diagnostic biomarker in inflammatory bowel disease
CONCLUSION: H19 and miRNA-675-5p can be used as diagnostic biomarkers in IBD, with superiority in UC patients with moderate activity.PMID:37716920 | DOI:10.1007/s11033-023-08777-8
Source: Molecular Biology Reports - September 16, 2023 Category: Molecular Biology Authors: Olfat G Shaker Aya Safa Ahmed Khairy Naglaa F Abozeid Source Type: research
The role of galectin-3 in patients with permanent and paroxysmal Atrial Fibrillation and echocardiographic parameters of left atrial fibrosis
CONCLUSIONS: Echocardiographic findings showed association with the groups, and with serum levels of Gal-3 in patients with permanent AF. The distribution of allelic and genotypic frequencies, and of the haplotypes of polymorphism LGALS3 rs4652 and rs4644 did not present statistical variation, which suggests that those SNPs are not associated with the AF clinical forms (permanent and paroxysmal).PMID:37716919 | DOI:10.1007/s11033-023-08774-x
Source: Molecular Biology Reports - September 16, 2023 Category: Molecular Biology Authors: Maria Mariana Barros Melo da Silveira Jo ão Victor Batista Cabral Amanda Tavares Xavier Kleyton Palmeira do Ó Julio Francisco de Moura Junior Osm ário Tavares de Carvalho Edivaldo Bezerra Mendes Filho Taciana Furtado de Mendon ça Belmont Jos é Maria Source Type: research
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway
CONCLUSION: Knockdown of LIMD2 inhibits cell proliferation, migration, invasion and autophagy, and promotes the apoptosis through the ERK1/2 signaling pathway, suggesting that LIMD2-siRNA may be an effective molecule to prevent OC progression.PMID:37716918 | DOI:10.1007/s11033-023-08733-6
Source: Molecular Biology Reports - September 16, 2023 Category: Molecular Biology Authors: Haiyang Hu Yanan Wang Yan Dong Lin Wang Yahui Chen Yan Zhou Lin Sun Source Type: research
