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Total 131552 results found since Jan 2013.
Correction: Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
Mol Med. 2023 Sep 19;29(1):128. doi: 10.1186/s10020-023-00723-5.NO ABSTRACTPMID:37726670 | DOI:10.1186/s10020-023-00723-5
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Xiaoxia Xiao Huiling Hu Yadi Zhong Yingjian Chen Kaijia Tang Zhisen Pan Jiawen Huang Xiaoying Yang Qi Wang Yong Gao Source Type: research
Myocardial perfusion scintigraphy in the assessment of cardiovascular risk in adult liver transplantation
CONCLUSIONS: MPS is a safe and reliable technique for cardiovascular assessment of patients who are candidates for liver transplantation, given the low rate of false negatives during follow-up.PMID:37726078 | DOI:10.1016/j.remnie.2023.09.001
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: C Guti érrez-Villamil C Zuluaga-Arbelaez G Hern ández N Hern ández-Hidalgo V Mar ín-Oyaga Source Type: research
Emetine dihydrochloride alleviated radiation-induced lung injury through inhibiting EMT
In this study, we demonstrated that emetine dihydrochloride (EDD) alleviated RILI through inhibiting EMT. We found that EDD significantly attenuated EMT-related markers, reduced Smad3 phosphorylation expression after radiation. Then, for the first time, we observed EDD alleviated lung hyperaemia and reduced collagen deposit induced by irradiation, providing protection against RILI. Finally, it was found that EDD inhibited radiation-induced EMT in lung tissues. Our study suggested that EDD alleviated RILI through inhibiting EMT by blocking Smad3 signalling pathways. In summary, our results indicated that EDD is a novel pote...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Xin Wang Mo Li Jizhong Yin Jiayan Fang Yimeng Ying Tianxia Ye Fangxiao Zhang Shumei Ma Hongran Qin Xiaodong Liu Source Type: research
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
BMC Mol Cell Biol. 2023 Sep 19;24(1):28. doi: 10.1186/s12860-023-00489-y.ABSTRACTInflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells (GREC) which were induced SARA by Lipopolysaccharide (LPS) in vitro. The GREC were induced SARA by adding LPS at the concentration of 5 μm and glycyrrhizin was added at different concentration of 0, 60, 90, 120, 150 μm. The structural integrity of LPS-induced GREC with the treatment of glycyrrhizin were observed by electron microscope; ...
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Junfeng Liu Bei Ma Guang Hao DuoDuo Su Tianyang Wang Ze Ding Xuefeng Guo Source Type: research
Effects on gene expression during maize-Azospirillum interaction in the presence of a plant-specific inhibitor of indole-3-acetic acid production
Genet Mol Biol. 2023 Sep 18;46(3 Suppl 1):e20230100. doi: 10.1590/1678-4685-GMB-2023-0100. eCollection 2023.ABSTRACTAmongst the sustainable alternatives to increase maize production is the use of plant growth-promoting bacteria (PGPB). Azospirillum brasilense is one of the most well-known PGPB being able to fix nitrogen and produce phytohormones, especially indole-3-acetic acid - IAA. This work investigated if there is any contribution of the bacterium to the plant's IAA levels, and how it affects the plant. To inhibit plant IAA production, yucasin, an inhibitor of the TAM/YUC pathway, was applied. Plantlets' IAA concentra...
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Eliandro Espindula Edilena Reis Sperb Brenda Mor V ânia Carla Silva Pankievicz Thalita Regina Tuleski Michelle Zibetti Tadra-Sfeir Paloma Bonato Camila Scheid Josias Merib Emanuel Maltempi de Souza Luciane Maria Pereira Passaglia Source Type: research
Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor
Am J Respir Cell Mol Biol. 2023 Sep 19. doi: 10.1165/rcmb.2023-0127OC. Online ahead of print.ABSTRACTGeneration of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections remain unexplored. In the present study, we investigated the role of CD36 in mediating pulmonary endothelial cell (EC) ...
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Pratap Karki Yue Li Chen-Ou Zhang Yunbo Ke Kamoltip Promnares Anna A Birukova Thomas L Eggerman Alexander V Bocharov Konstantin G Birukov Source Type: research
In vitro naive CD4 < sup > + < /sup > T cell differentiation upon treatment with miR-29b-loaded exosomes from mesenchymal stem cells
CONCLUSIONS: In conclusion, AMSC-Exo-based delivery of miR-29b can be considered as a new fascinating avenue for T cell differentiation inhibition and the future treatment of several inflammatory disorders.PMID:37725284 | DOI:10.1007/s11033-023-08767-w
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Zohreh Bolandi Seyed Mahmoud Hashemi Mozhgan Abasi Maryam Musavi Shahin Aghamiri Nastaran Miyanmahaleh Hossein Ghanbarian Source Type: research
Transcription Repression of CRY2 via PER2 Interaction Promotes Adipogenesis
Mol Cell Biol. 2023 Sep 19:1-15. doi: 10.1080/10985549.2023.2253710. Online ahead of print.ABSTRACTThe circadian clock is driven by a transcriptional-translational feedback loop, and cryptochrome 2 (CRY2) represses CLOCK/BMAL1-induced transcription activation. Despite the established role of clock in adipogenic regulation, whether the CRY2 repressor activity functions in adipocyte biology remains unclear. Here we identify a critical cysteine residue of CRY2 that mediates interaction with Period 2 (PER2). We further demonstrate that this mechanism is required for repressing circadian clock-controlled Wnt signaling to promot...
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Weini Li Xuekai Xiong Tali Kiperman Ke Ma Source Type: research
The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1
Mol Cell Biol. 2023 Sep 19:1-15. doi: 10.1080/10985549.2023.2255120. Online ahead of print.ABSTRACTIRES mediated translation initiation requires a different repertoire of factors than canonical cap-dependent translation. Treatments that inhibit the canonical translation factor EIF4G1 have little or no effect on the ability of the Insr and Igf1r cellular IRESes to promote translation. Transcripts for two cellular receptors contain RNA elements that facilitate translation initiation without intact EIF4G1. Cellular IRES mechanisms may resemble viral type III IRESes allowing them to promote translate with a limited number of i...
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Nicholas K Clark Meghan T Harris William B Dahl Zachary Knotts Michael T Marr Source Type: research
RT-qPCR Analysis of LAMP3 (CD208) Gene Expression in Oral Lichen Planus and Oral Squamous Cell Carcinoma
CONCLUSIONS: According to the findings of this study, it can be concluded that the expression of the LAMP3 gene in SCC lesions is higher than in healthy tissue. Hence, LAMP3 gene expression can be used as a diagnostic biomarker.PMID:37724152 | PMC:PMC10505466 | DOI:10.52547/rbmb.12.1.36
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Farnaz Mohajertehran Nooshin Mohtasham Mojtaba Ahmadi Mehdi Shahabinejad Maryam Mohammadi Source Type: research
Effect of miR-18a-5p, miR-19a-3p, and miR-20a-5p on < em > In Vitro < /em > Cardiomyocyte Differentiation of Human Endometrium Tissue-Derived Stem Cells Through Regulation of Smad4 Expression
CONCLUSION: Our results indicate that miR-18a-5p, miR-19a-3p, and miR-20a-5p are involved in the cardiac differentiation propensity of hEMSCs potentially by regulation of Smad levels. Although, more mechanistic experiments are required to confirm this idea.PMID:37724150 | PMC:PMC10505458 | DOI:10.52547/rbmb.12.1.136
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Behnaz Maleki Mahdi Noureddini Somayeh Saadat Javad Verdi Alireza Farrokhian Hossein Ghanbarian Ebrahim Cheraghi Behrang Alani Source Type: research
Anti-Cancer Effect of < em > Dorema Ammoniacum Gum < /em > by Targeting Metabolic Reprogramming by Regulating < em > APC, P53, KRAS < /em > Gene Expression in HT-29 Human Colon Cancer Cells
CONCLUSION: This study's results indicate that the dichloromethane solvent of Dorema ammoniacum gum exhibits its antitumor properties by altering the expression of genes involved in HT-29 cells and the consequent change in downstream metabolic reprogramming.PMID:37724146 | PMC:PMC10505474 | DOI:10.52547/rbmb.12.1.127
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Elham Ghodousi-Dehnavi Mohammad Arjmand Ziba Akbari Mansour Aminzadeh Reza Haji Hosseini Source Type: research
Farnesyltransferase (FTase) Inhibitors Increase Inhibition of KIT Mutants by Imatinib
CONCLUSIONS: Our results suggested the potential benefit of farnesyltransferase inhibitors either alone or combined with imatinib in the treatment of gastrointestinal stromal tumors carrying KIT mutations.PMID:37724142 | PMC:PMC10505455 | DOI:10.52547/rbmb.12.1.74
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Zhaoyang Fan Liangying Zhang Shaoting Zhang Anbu Liu Shujing Li Xu Cao Jinhai Tian Sien Zhao Jianmin Sun Source Type: research
The Prognostic Significance of P16 Immunohistochemical Expression Pattern in Women with Invasive Ductal Breast Carcinoma
CONCLUSIONS: Our study demonstrated that p16 protein expression increased in ER-positive tumor tissue from patients with invasive ductal breast carcinoma. However, no correlation was found between the p16 protein expression and the other clinicopathological features.PMID:37724141 | PMC:PMC10505467 | DOI:10.52547/rbmb.12.1.83
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Alireza Rezaei Navidreza Shayan Saman Shirazinia Sara Mollazadeh Negin Ghiyasi-Moghaddam Source Type: research
Transcriptome Data Reveal Geographic Heterogeneity in Gene Expression in Patients with Prostate Cancer
CONCLUSIONS: This study suggests that geographic heterogeneity in PC incidence is associated with the expression levels of genes associated with amino acid metabolism, lipid metabolism, and ion channels.PMID:37724140 | PMC:PMC10505463 | DOI:10.52547/rbmb.12.1.92
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Yi Zheng Yang Wang Haitian He Zhuping Zou Huiling Lu Jinlong Li Jun Cai Kebing Wang Source Type: research
