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Total 131552 results found since Jan 2013.
PET/CT-based deep learning grading signature to optimize surgical decisions for clinical stage I invasive lung adenocarcinoma and biologic basis under its prediction: a multicenter study
CONCLUSION: The DLGS harbors the potential to predict the histologic grade and personalize the surgical treatments for clinical stage I invasive lung adenocarcinoma. Its applicability to other territories should be further validated by a larger international study.PMID:37725128 | DOI:10.1007/s00259-023-06434-7
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Yifan Zhong Chuang Cai Tao Chen Hao Gui Cheng Chen Jiajun Deng Minglei Yang Bentong Yu Yongxiang Song Tingting Wang Yangchun Chen Huazheng Shi Dong Xie Chang Chen Yunlang She Source Type: research
Large extracellular vesicles derived from human regulatory macrophages (L-EV < sub > Mreg < /sub > ) attenuate CD3/CD28-induced T-cell activation in vitro
J Mol Med (Berl). 2023 Sep 19. doi: 10.1007/s00109-023-02374-9. Online ahead of print.ABSTRACTMacrophages belong to the innate immune system, and we have recently shown that in vitro differentiated human regulatory macrophages (Mreg) release large extracellular vesicles (L-EVMreg) with an average size of 7.5 μm which regulate wound healing and angiogenesis in vitro. The aim of this study was to investigate whether L-EVMreg also affect the CD3/CD28-mediated activation of T-cells. Mreg were differentiated using blood monocytes and L-EVMreg were isolated from culture supernatants by differential centrifugation. Activation of...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Martin Albrecht Lars Hummitzsch Rene Rusch Christine Eimer Melanie Rusch Katharina He ß Markus Steinfath Jochen Cremer Fred F ändrich Rouven Berndt Karina Zitta Source Type: research
PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice
EMBO Mol Med. 2023 Sep 19:e17683. doi: 10.15252/emmm.202317683. Online ahead of print.ABSTRACTSpinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless, these are not without limitations, and research efforts are underway to develop new approaches for improved and long-lasting benefits for patients. Protein arginine methyltransferases (PRMTs) are emerging as druggable epigenetic targets, with several small-molecule PRMT inhibitors already in clinical ...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Anna J Kordala Jessica Stoodley Nina Ahlskog Muhammad Hanifi Antonio Garcia Guerra Amarjit Bhomra Wooi Fang Lim Lyndsay M Murray Kevin Talbot Suzan M Hammond Matthew Ja Wood Carlo Rinaldi Source Type: research
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer
Conclusion: Nuclear imaging plays an important role in the diagnosis, staging, and management of thyroid cancer. The use of radioiodine imaging, thyroglobulin imaging, FDG imaging, and somatostatin receptor imaging are all valuable tools in the evaluation of thyroid cancer. With further research and development, nuclear imaging techniques have the potential to improve the diagnosis and management of thyroid cancer and other endocrine malignancies.PMID:37724677 | DOI:10.2174/1566524023666230915103723
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Namit Kant Singh Neemu Hage Balaji Ramamourthy Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17940. Online ahead of print.ABSTRACTThe widespread emergence of antimalarial drug resistance has created a major threat to public health. Malaria is a life-threatening infectious disease caused by Plasmodium spp., which includes Apicoplast DNA polymerase and Plasmodium falciparum cysteine protease falcipain-2. These components play a critical role in their life cycle and metabolic pathway, and are involved in the breakdown of erythrocyte hemoglobin in the host, making them promising targets for anti-malarial drug design. Our current study has been designed to explore the pote...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Shopnil Akash Guendouzi Abdelkrim Imren Bayil Md Eram Hosen Nobendu Mukerjee Abdullah F Shater Fayez M Saleh Ghadeer M Albadrani Muath Q Al-Ghadi Mohamed M Abdel-Daim Tu ğba Taşkin Tok Source Type: research
An effective disease diagnostic model related to pyroptosis in ischemic cardiomyopathy
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17957. Online ahead of print.ABSTRACTPyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to investigate the pyroptosis-related genes and clarify their diagnostic value in ICM. The bioinformatics method identified the differential pyroptosis genes between the normal control and ICM samples from online datasets. Then, protein-protein interaction (PPI) and function analysis were carried out to explore the function of these genes. Following, subtype analysis was performed using ConsensusClusterPlus, functions, immune score, stromal score, immune cell proportio...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Zhankui Jin Fuqiang Liu Guoan Zhang Jingtao Zhang Xiangrong Zhao Xueping Huo Xiaoyan Huang Cuixiang Xu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
corrigendum
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17829. Online ahead of print.NO ABSTRACTPMID:37724039 | DOI:10.1111/jcmm.17829
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Source Type: research
Corrigendum
J Cell Mol Med. 2023 Sep 18. doi: 10.1111/jcmm.17830. Online ahead of print.NO ABSTRACTPMID:37723981 | DOI:10.1111/jcmm.17830
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Source Type: research
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans
CONCLUSION: Our results suggested that in oral epithelial cells, the NLRP3 inflammasome might be one of the target pathways by which CSE attenuates innate immunity and leads to oral disorders.PMID:37723958 | DOI:10.2174/1566524023666230612143038
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Fan Huang Ruiqi Xie Ruowei Li Liu Liu Maomao Zhao Qiong Wang Weida Liu Pei Ye Wenmei Wang Xiang Wang Source Type: research
Emetine dihydrochloride alleviated radiation-induced lung injury through inhibiting EMT
In this study, we demonstrated that emetine dihydrochloride (EDD) alleviated RILI through inhibiting EMT. We found that EDD significantly attenuated EMT-related markers, reduced Smad3 phosphorylation expression after radiation. Then, for the first time, we observed EDD alleviated lung hyperaemia and reduced collagen deposit induced by irradiation, providing protection against RILI. Finally, it was found that EDD inhibited radiation-induced EMT in lung tissues. Our study suggested that EDD alleviated RILI through inhibiting EMT by blocking Smad3 signalling pathways. In summary, our results indicated that EDD is a novel pote...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Xin Wang Mo Li Jizhong Yin Jiayan Fang Yimeng Ying Tianxia Ye Fangxiao Zhang Shumei Ma Hongran Qin Xiaodong Liu Source Type: research
Mutations in CFAP47, a previously reported MMAF causative gene, also contribute to the respiratory defects in patients with PCD
CONCLUSIONS: We describe two hemizygous missense variants of X-linked CFAP47 in two unrelated PCD individuals and prove CFAP47 variants are related to a reduced number of epithelial ciliary cells. Therefore, we suggest that CFAP47 should be known as a novel pathogenic gene of human PCD.PMID:37723893 | DOI:10.1002/mgg3.2278
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Haijun Ge Wangji Zhou Miao He Haixia Zheng Xinyue Zhao Ting Zhang Ying Zhang Chi Shao Chongsheng Cheng Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang Source Type: research
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research
A dual-role for IL-10: From leukemogenesis to the tumor progression in acute lymphoblastic leukemia
Cytokine. 2023 Sep 17;171:156371. doi: 10.1016/j.cyto.2023.156371. Online ahead of print.ABSTRACTAcute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the world, and accounts for 25% of all childhood cancers among children under 15 years of age. Longitudinal studies have shown that children with ALL are born with a deregulated immune response that, together with postnatal environmental exposures, favor the onset of the disease. In this context, IL-10, a key cytokine in the regulation of the immune response, presents itself as a paradoxical mediator, initially influencing the development of ALL through t...
Source: Cytokine - September 19, 2023 Category: Molecular Biology Authors: Flavio Souza Silva Amanda Barros-Lima Mateus Souza-Barros Juniel Assis Crespo-Neto Vit ória Giovanna Rodrigues Santos Daniele S á Pereira Fab íola Silva Alves-Hanna F ábio Magalhães-Gama Jerusa Ara újo Quintão Arantes Faria Allyson Guimar ães Cost Source Type: research
Structural basis for inhibition of a GH116 β-glucosidase and its missense mutants by GBA2 inhibitors: Crystallographic and quantum chemical study
Chem Biol Interact. 2023 Sep 17:110717. doi: 10.1016/j.cbi.2023.110717. Online ahead of print.ABSTRACTThe crystal structure of the Thermoanaerobacterium xylanolyticum in glycoside hydrolase family 116 (TxGH116) β-glucosidase provides a structural model for human GBA2 glucosylceramidase, an enzyme defective in hereditary spastic paraplegia and a potential therapeutic target for treating Gaucher disease. To assess the therapeutic potential of known inhibitors, the X-ray structure of TxGH116 in complex with isofagomine (IFG) was determined at 2.0 Å resolution and showed the IFG bound in a relaxed chair conformation. The bin...
Source: Chemico-Biological Interactions - September 19, 2023 Category: Molecular Biology Authors: Wijitra Meelua Natechanok Thinkumrob Patchreenart Saparpakorn Salila Pengthaisong Supa Hannongbua James R Ketudat Cairns Jitrayut Jitonnom Source Type: research
