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Total 131552 results found since Jan 2013.
Concordance of ctDNA and tissue mutations in NSCLC: A meta-analysis
This article includes a total of 15 research data and collected data reports from 15 groups of NSCLC patients. The results are displayed using tissue samples as the gold standard. The Pearson correlation coefficients of sensitivity and specificity were used to calculate rho=0.044, and P=0.893. The Q-test found poor homogeneity and high heterogeneity in sensitivity and specificity among research data from various literature studies (I2>50%, P<0.1). The area under the SROC curve is 0.97 (95% CI: 0.96~0.99). The small sample subgroup has high heterogeneity, and the combined diagnosis effect size is 26[6~111], lower than...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Chengyuan Yu Yitong Han Mu Wang Peiyan Hua Yan Zhang Bin Wang Source Type: research
The relationship between tissue differentiation-inducing non-protein coding RNA expression and tumor size in patients with breast cancer
This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to eval...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Shen Tan Aimin Cui Nan Bai Zicui Zhang Source Type: research
Changes of Gut Microbiota in Maintenance Hemodialysis Patients and Their Impact on Patient's Microinflammation Status
In conclusion, patients with maintenance hemodialysis for CKD commonly exhibit gut microbiota dysbiosis and varying degrees of low-grade inflammation. Compared to healthy individuals, maintenance hemodialysis patients with CKD have lower levels of Bifidobacterium and Lactobacillus and higher levels of Escherichia coli and Enterococcus in their gut. Bifidobacterium, Lactobacillus, Escherichia coli, and Enterococcus all have a certain impact on the low-grade inflammation status of patients with maintenance hemodialysis for CKD.PMID:37715414 | DOI:10.14715/cmb/2023.69.8.15
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Xiaopan Zhang Yilin Wang Ying Yin Bo Sun Guangren Chen Fengling Chen Source Type: research
The Role of Parkin in Rat Pancreatic Beta Cells Fate
In this study, we investigated whether Parkin affects cell viability and ER stress responses under lipotoxic conditions in INS-1E cells. Our results may suggest that silencing Parkin may affect autophagy in addition to apoptosis. We also showed that Parkin may have a protective effect against lipo-toxic effects in INS-1E cells. Consistent with previous studies, we observed that stress responses were different for high and low palmitic acid doses. The Parkin being inhibited under high-dose PA treatment and active under low-dose PA treatment indicate that regulation of stress responses is controlled by environmental conditio...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasibe Verdi Hatice Pinar Baysan Cebi Yaprak Yilmaz Yalcin Tulin Ozkan Mehtap Akcil Ok Asuman Sunguroglu Fatma Belgin Atac Source Type: research
MiRNA a New Insight in Metabolic and Human Diseases: A Review
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):102-110. doi: 10.14715/cmb/2023.69.8.16.ABSTRACTThe purpose of this research is to examine existing studies on the association between microRNAs (miRNA) and age-related disorders. The miRNAs are small, noncoding RNA molecules with the ability to regulate gene expression. These are well-established in extracellular circulation, including various types of diseases such as cancer, cardiovascular diseases, and diabetes. Similarly, several miRNAs are associated with certain age-related conditions, such as increased miR-21 expression in cancer patients. Besides that, the miR-122 ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ibrahim Jafri Source Type: research
Bisphenol-A exposure alters liver, kidney, and pancreatic Klotho expression by HSP60-activated mTOR/autophagy pathway in male albino rats
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):109-117. doi: 10.14715/cmb/2023.69.7.18.ABSTRACTThe effect of bisphenol-A (BPA) on Klotho protein (aging-suppressing protein) expression in different body organs has not been sufficiently addressed by literature studies. The study investigated the impact of BPA on Klotho expression in multiple organs including the liver, kidney, and pancreas and suggested the involved molecular pathways. Twenty-seven male Wistar albino rats were divided into 3 equal groups: control, low-dose BPA (4.5 µg/L), and high-dose BPA (8 µg/L) groups in drinking water for 45 consecutive days. Liver...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ahmed A Morsi Ezat A Mersal Ahmed Othman Alsabih Shaimaa Alakabawy Riham G Elfawal Eman M Sakr Eman Mohamed Faruk Mohammed Abu-Rashed Fatimah Alhaddad Zahra Alkhawajah Abdulrahman Hasari Khalid Elfaki Ibrahim Ibrahim Ahmed M Abdelmoneim Source Type: research
γ-tocopherol methyltransferase gene sequencing and SNP discovery associated with olive oil quality
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):111-117. doi: 10.14715/cmb/2023.69.8.17.ABSTRACTγ-tocophérol methyltransferase (GTMT), a key enzyme in the tocopherols biosynthesis pathway, is involved in the conversion of δ- and l'γ-tocophérol to β- et l'α-tocophérol, respectively. In fact, it plays an important role in the α-tocopherol composition and the quality of olive oil. A total of 14 olive tree cultivars (Olea Europaea L.) were chosen and used in this study. They were sampled from different regions of Tunisia. Four cultivars from four Mediterranean regions (Greece, Algeria, Morocco, and Spain) were inclu...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Nadia Ayadi None Rayda Ben Ayed Sezai Ercisli Melekber Sulusoglu Durul Ebru Sakar Ahmed Rebai Source Type: research
Effect of Yifei Qinghua Granule on the Tumor Microenvironment in Lung Cancer by Regulating the Inflammatory Pathway
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):118-124. doi: 10.14715/cmb/2023.69.8.18.ABSTRACTTo investigate the mechanism of action of inflammatory molecules regulating the tumor microenvironment and anti-tumor through Yifei Qinghua granules and phloroglucinol-containing serum intervening in the changes of tumor microenvironment in vitro in the co-culture of lung cancer cells and bone marrow cells. A549 lung adenocarcinoma cell line and ST2 bone marrow stromal cell line were selected and a transwell chamber was used to establish the co-culture system of the two kinds of cells. They were divided into normal saline, phl...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: LiHong Zhang Zhijiang Zhuang Liang Geng G E Wang Yun Cui Tongde Tian Sheng Wang Bian Shi Source Type: research
Screening of natural products atlas for identification of lead molecule to treat angina pectoris using bioinformatics approaches
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):125-131. doi: 10.14715/cmb/2023.69.8.19.ABSTRACTAngina pectoris is amongst the most common diseases. There is a scarcity of effective treatments for this disease. As a result, there is a significant clinical and social interest in predicting and developing novel compounds to treat cardiovascular disorders. So, specific natural products have been screened in this study because they have protective effects against angiotensin-converting enzymes. When taken orally, natural products can help protect against or lessen the severity of angina and heart damage. Natural compounds in...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Aziz Unnisa Suresh B Jandrajupalli Badria A Elamine Omkalthoum A Mohamed Khetam Saad Alreshidi Aliyah Hamdan Alshammari Hajer Shaty Alshammari Norah Bandar Ramana Gangireddy Source Type: research
Characterization of Multiple Resistance Genes of Escherichia coli Strains Isolated from Food and Clinical Samples
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):118-126. doi: 10.14715/cmb/2023.69.7.19.ABSTRACTMulti-drug resistance (MDR), which is formed by the development of antimicrobial resistance, which is one of the defense mechanisms in bacteria, has pushed human beings to constantly seek new antimicrobial agents in the fight against these microorganisms. Speed and precision are very important in identifying resistance in strains with MDR that reach humans in an open system through the consumption of contaminated food or water. The main aim of this study was the molecular characterization of ESBL gene variants (blaTEM, blaOXA,...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Birg ül Yelimlibağ Muhsin Aydin Source Type: research
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Alth...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasan G ündoğar Hakan Özdemir Zeynep Deniz Şahin İnan Source Type: research
Anti-aging Effect of Allium pseudojaponicum in UVA-irradiated Human Epidermal Keratinocytes
This study was conducted to investigate the anti-aging effects of Allium pseudojaponicum extract on normal human epidermal keratinocytes (NHEKs). The effects were examined by analyzing gene expressions related to skin hydration using quantitative real-time polymerase chain reaction (qRT-PCR), hyaluronic acid (HA) production using HA-ELISA, cell viability using a cell viability assay, and a phospho-kinase array. Allium pseudojaponicum extract increased the gene expression levels of AQP3/HAS2 and HA protein production in NHEKs while decreasing the overexpressed mRNA levels of KRT1, 10 and FLG genes, known as differentiated k...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Joong Hyun Shim Source Type: research
Effect of Different Plant Extracts on Microbial Population in The Frozen African Catfish (Clarias gariepinus) Semen
This study sought to assess the potential of various plant extracts to function as natural antimicrobial agents in the frozen semen of African catfish (Clarias gariepinus). Diluted sperm was packaged in 0.25ml straws and left for 10min equilibration at 4°C. Following equilibration, the straws were exposed to liquid nitrogen vapor for 10 min and plunged into the liquid nitrogen (-196°C) and then thawed in a water bath at 35°C for 20s. Sperm samples were put into sterile 1.5 ml tubes immediately after thawing and the microbial count was detected with classical microbiological culture method. In the results of microbiologi...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Faik Sertel Secer Ilker Yavas Zafer Cantekin Yusuf Bozkurt Tugba Korkmaz Yavas Alexander Atanasoff Source Type: research
Relationship between Dental Caries Experience and the Levels of Streptococcus mutans and Lactobacillus in Saliva of Pregnant Women
This study aims to correlate dental caries experience with Streptococcus mutans and lactobacillus levels in saliva using real-time PCR. This case-control analytical study conducted in Erbil City, Iraq, between 2021 and 2023 used a Cariogram to assess tooth decay risk and a real-time PCR assay to detect oral bacteria. Kurdish chewing gum with oil extract was used to stimulate saliva production. The chance of preventing tooth decay was 50.57% in pregnant women and 60.26% in non-pregnant women, with a statistically significant difference. The correlation between caries risk categories and Streptococcus mutans and Lactobacillu...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Fighan Jalal Hussein Sazan Sherdl Saleem Khalid Abdulaziz Merdad Source Type: research
Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):84-88. doi: 10.14715/cmb/2023.69.8.13.ABSTRACTTo investigate the inhibitory mechanism of the KIF3A gene on nasopharyngeal carcinoma (NPC) tumor stem cells. Set up a blank control group (BCG), NPC group, and KIF3A silence (si-KIF3A) group. The BCG cells were nasopharyngeal normal epithelial cell line NP69, without any treatment, and were cultured routinely; The NPC group cells are human NPC cell line CNE2 cells, which are not subjected to any treatment and are cultured routinely; si-KIF3A group cells were cultured in the offspring of human NPC cell line CNE2 infected with Le...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Rongrong Liu Te Li Weitao Zhang Source Type: research
