Filtered By:
Infectious Disease: Tuberculosis
This page shows you your search results in order of date.
Order by Relevance | Date
Total 20175 results found since Jan 2013.
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species
Chembiochem. 2023 Sep 20:e202300570. doi: 10.1002/cbic.202300570. Online ahead of print.ABSTRACTFidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram-positive bacteria such as Mycobacterium tuberculosis. Only few Fdx derivatives have been synthesized and examined for their biological activity in the 50 years since its discovery. Fdx has a well-studied mechanism of action, namely inhibition of the bacterial RNA polymerase. Yet, the targeted organisms harbor different target protein sequences, which poses a challenge for the rational development of new semisynt...
Source: Chembiochem - September 20, 2023 Category: Biochemistry Authors: Erik Jung Anastassia Kraimps Silvia Dittmann Tizian Griesser Jordan Costafrolaz Yves Mattenberger Simon Jurt Patrick H Viollier Peter Sander Susanne Sievers Karl Gademann Source Type: research
AHL score for predicting mortality risk in patients with pulmonary tuberculosis
Chest. 2023 Sep 17:S0012-3692(23)05434-X. doi: 10.1016/j.chest.2023.09.008. Online ahead of print.ABSTRACTBACKGROUND: A clinically applicable mortality-risk prediction system for pulmonary tuberculosis may improve treatment outcomes, but no easy-to-calculate and accurate score has yet been reported. We aimed to construct a simple and objective disease-severity score for patients with pulmonary tuberculosis.RESEARCH QUESTION: Does a clinical score consisting of simple objective factors predict the mortality risk of patients with pulmonary tuberculosis?STUDY DESIGN AND METHODS: The dataset from our previous prospective study...
Source: Chest - September 19, 2023 Category: Respiratory Medicine Authors: Takeshi Osawa Masato Watanabe Kozo Morimoto Takashi Yoshiyama Shuichi Matsuda Keiji Fujiwara Koji Furuuchi Masafumi Shimoda Masashi Ito Tatsuya Kodama Fumiko Uesugi Masao Okumura Yoshiaki Tanaka Yuka Sasaki Hideo Ogata Hajime Goto Shoji Kudoh Ken Ohta Source Type: research
Upfront tofacitinib in patients with biological-na ïve ulcerative colitis - An Indian multicentric experience
CONCLUSION: Upfront tofacitinib is effective in biologic-naïve Indian patients with moderate-severe UC. Further randomized studies are required to validate the study findings.PMID:37726491 | DOI:10.1007/s12664-023-01434-9
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Suprabhat Giri Sukanya Bhrugumalla Abhishek Kamuni Debakanta Mishra Girish Kumar Pati Dhiraj Agrawal Govind Verma Rohit Wagh Shamshersingh Chauhan Meghraj Ingle Sanjay Chandnani Shubham Jain Pravin M Rathi Akash Shukla Aditya Kale Source Type: research
AHL score for predicting mortality risk in patients with pulmonary tuberculosis
Chest. 2023 Sep 17:S0012-3692(23)05434-X. doi: 10.1016/j.chest.2023.09.008. Online ahead of print.ABSTRACTBACKGROUND: A clinically applicable mortality-risk prediction system for pulmonary tuberculosis may improve treatment outcomes, but no easy-to-calculate and accurate score has yet been reported. We aimed to construct a simple and objective disease-severity score for patients with pulmonary tuberculosis.RESEARCH QUESTION: Does a clinical score consisting of simple objective factors predict the mortality risk of patients with pulmonary tuberculosis?STUDY DESIGN AND METHODS: The dataset from our previous prospective study...
Source: Chest - September 19, 2023 Category: Respiratory Medicine Authors: Takeshi Osawa Masato Watanabe Kozo Morimoto Takashi Yoshiyama Shuichi Matsuda Keiji Fujiwara Koji Furuuchi Masafumi Shimoda Masashi Ito Tatsuya Kodama Fumiko Uesugi Masao Okumura Yoshiaki Tanaka Yuka Sasaki Hideo Ogata Hajime Goto Shoji Kudoh Ken Ohta Source Type: research
Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase
Bioorg Med Chem. 2023 Sep 9;94:117466. doi: 10.1016/j.bmc.2023.117466. Online ahead of print.ABSTRACTA pyrazole-based compound, MS208, was previously identified as an inhibitor of UDP-Galactopyranose Mutase from Mycobacterium tuberculosis (MtUGM). Targeting this enzyme is a novel therapeutic strategy for the development of new antituberculosis agents because MtUGM is an essential enzyme for the bacterial cell wall synthesis and it is not present in human. It was proposed that MS208 targets an allosteric site in MtUGM as MS208 followed a mixed inhibition model. DA10, an MS208 analogue, showed competitive inhibition rather t...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Dalia M Ahmed David A R Sanders Source Type: research
A Very Unusual Presentation of Miliary Tuberculosis and Osteomyelitis as an Incidental Finding of Musculoskeletal Pain
Cureus. 2023 Aug 27;15(8):e44207. doi: 10.7759/cureus.44207. eCollection 2023 Aug.ABSTRACTTuberculosis (TB) is a highly infectious disease that takes the primary or latent route. In primary TB, the patient often presents with constitutional symptoms such as cough, fever, weight loss, and hemoptysis. This 83-year-old patient was sent to the emergency department (ED) by her primary care physician after abnormal imaging for acute back and neck pain. Imaging revealed pulmonary TB with possible tuberculosis osteomyelitis versus metastatic carcinoma to the cervical vertebrae. The case's unique presentation gives light to the nee...
Source: Pain Physician - September 18, 2023 Category: Anesthesiology Authors: Prachi B Patel Bhavi Purohit Source Type: research
Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase
Bioorg Med Chem. 2023 Sep 9;94:117466. doi: 10.1016/j.bmc.2023.117466. Online ahead of print.ABSTRACTA pyrazole-based compound, MS208, was previously identified as an inhibitor of UDP-Galactopyranose Mutase from Mycobacterium tuberculosis (MtUGM). Targeting this enzyme is a novel therapeutic strategy for the development of new antituberculosis agents because MtUGM is an essential enzyme for the bacterial cell wall synthesis and it is not present in human. It was proposed that MS208 targets an allosteric site in MtUGM as MS208 followed a mixed inhibition model. DA10, an MS208 analogue, showed competitive inhibition rather t...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Dalia M Ahmed David A R Sanders Source Type: research
Highlights 56th SEPAR Congress
Open Respir Arch. 2023 Sep 1;5(3):100265. doi: 10.1016/j.opresp.2023.100265. eCollection 2023 Jul-Sep.ABSTRACTThe Spanish Society of Pneumology and Thoracic Surgery (SEPAR) has held its 56th congress in Granada from 8 to 10 June 2023. The SEPAR congress has established itself as the leading scientific meeting for specialists in medicine and respiratory care, reaching a record of participation this year with 2600 attendees. Our society thus demonstrates its leadership in the management of respiratory diseases, as well as its growth and progress in order to achieve excellence. In this review, we offer a summary of some notab...
Source: Respiratory Care - September 18, 2023 Category: Respiratory Medicine Authors: Pablo S ánchez-Salcedo Ana Bel én Llanos-González Sandra Dorado Arenas Noelia Carri ón Collado Agust ín Roberto García Marta S ánchez Zaballos Tamara Alonso P érez Source Type: research
The relevance of clinical and epidemiological correlation in the early diagnosis of histoplasmosis: report of two clinical cases in Popay án, Colombia
Biomedica. 2023 Aug 31;43(Sp. 1):20-31. doi: 10.7705/biomedica.6782.ABSTRACTHistoplasmosis is an endemic mycosis in Colombia. Here we present two cases in the Cauca department, to indicate the clinical impact of histoplasmosis delayed diagnosis and treatment when its epidemiology is unknown. Informed consent was requested to review patients’ medical records and case report publication. The first case was a patient diagnosed with human immunodeficiency virus and generalized presence of skin lesions. Initially, these lesions were diagnosed as herpes, but a postmortem diagnosis confirmed histoplasmosis through fungal cultur...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Jorge Andr és Potosí Yina Marcela Guti érrez Fabiola Eugenia Gonz ález Source Type: research
La importancia de la correlaci ón clínico-epidemiológica en el diagnóstico temprano de la histoplasmosis: reporte de dos casos clínicos en Popayán, Colombia
Biomedica. 2023 Aug 31;43(Sp. 1):20-31. doi: 10.7705/biomedica.6782.ABSTRACTLa histoplasmosis es una micosis endémica en Colombia. Se presentan dos casos del departamento del Cauca, para mostrar el impacto clínico que conlleva un retraso en su diagnóstico y tratamiento. Se obtuvo el consentimiento informado para revisar las historias clínicas de los pacientes y publicar los casos. El primer caso se trata de un paciente con infección por el virus de inmunodeficiencia humana (Human Immunodeficiency Virus, HIV), quien presentaba lesiones cutáneas generalizadas atribuidas inicialmente al virus del herpes; post mortem y m...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Jorge Andr és Potosí Yina Marcela Guti érrez Fabiola Eugenia Gonz ález Source Type: research
A Very Unusual Presentation of Miliary Tuberculosis and Osteomyelitis as an Incidental Finding of Musculoskeletal Pain
Cureus. 2023 Aug 27;15(8):e44207. doi: 10.7759/cureus.44207. eCollection 2023 Aug.ABSTRACTTuberculosis (TB) is a highly infectious disease that takes the primary or latent route. In primary TB, the patient often presents with constitutional symptoms such as cough, fever, weight loss, and hemoptysis. This 83-year-old patient was sent to the emergency department (ED) by her primary care physician after abnormal imaging for acute back and neck pain. Imaging revealed pulmonary TB with possible tuberculosis osteomyelitis versus metastatic carcinoma to the cervical vertebrae. The case's unique presentation gives light to the nee...
Source: Pain Physician - September 18, 2023 Category: Anesthesiology Authors: Prachi B Patel Bhavi Purohit Source Type: research
Highlights 56th SEPAR Congress
Open Respir Arch. 2023 Sep 1;5(3):100265. doi: 10.1016/j.opresp.2023.100265. eCollection 2023 Jul-Sep.ABSTRACTThe Spanish Society of Pneumology and Thoracic Surgery (SEPAR) has held its 56th congress in Granada from 8 to 10 June 2023. The SEPAR congress has established itself as the leading scientific meeting for specialists in medicine and respiratory care, reaching a record of participation this year with 2600 attendees. Our society thus demonstrates its leadership in the management of respiratory diseases, as well as its growth and progress in order to achieve excellence. In this review, we offer a summary of some notab...
Source: Respiratory Care - September 18, 2023 Category: Respiratory Medicine Authors: Pablo S ánchez-Salcedo Ana Bel én Llanos-González Sandra Dorado Arenas Noelia Carri ón Collado Agust ín Roberto García Marta S ánchez Zaballos Tamara Alonso P érez Source Type: research
Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase
Bioorg Med Chem. 2023 Sep 9;94:117466. doi: 10.1016/j.bmc.2023.117466. Online ahead of print.ABSTRACTA pyrazole-based compound, MS208, was previously identified as an inhibitor of UDP-Galactopyranose Mutase from Mycobacterium tuberculosis (MtUGM). Targeting this enzyme is a novel therapeutic strategy for the development of new antituberculosis agents because MtUGM is an essential enzyme for the bacterial cell wall synthesis and it is not present in human. It was proposed that MS208 targets an allosteric site in MtUGM as MS208 followed a mixed inhibition model. DA10, an MS208 analogue, showed competitive inhibition rather t...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Dalia M Ahmed David A R Sanders Source Type: research
