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Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region
Am J Trop Med Hyg. 2023 Aug 21:tpmd230039. doi: 10.4269/ajtmh.23-0039. Online ahead of print.ABSTRACTTuberculosis remains a challenge in both rural and urban areas. Although a majority of countries display a higher burden in urban areas compared with rural areas, Panama continues to report the highest mortality rate in Central America. Urban areas, such as Panama City, report a high tuberculosis burden, whereas Panama's western region, including the provinces of Chiriquí, Bocas del Toro (both semiurban) and Ngäbe-Bugle (rural), show a lower burden. We aimed to identify highly transmitted Mycobacterium tuberculosis strain...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Fermin Acosta Ricardo Salda ña Sara Miranda Daniela Candanedo Dilcia Sambrano Mitchelle Mor án Saily Bejarano Yeraldine De Arriba Angel Reigosa Elizabeth De Dixon Mar ía Atencio Ram ón Castillo Amador Goodridge Source Type: research
Etiologic Investigation of Patients Diagnosed with Bacteriologically Unconfirmed Tuberculosis in Tanzania
Am J Trop Med Hyg. 2023 Aug 21:tpmd230023. doi: 10.4269/ajtmh.23-0023. Online ahead of print.ABSTRACTGlobally, half of patients with pulmonary tuberculosis (PTB) are diagnosed clinically without bacteriologic confirmation. In clinically diagnosed PTB patients, we assessed both the proportion in whom PTB could be bacteriologically confirmed by reference standard diagnostic tests and the prevalence of diseases that mimic PTB. We recruited adult patients beginning treatment of bacteriologically unconfirmed PTB in Moshi, Tanzania, in 2019. We performed mycobacterial smear, Xpert MTB/RIF Ultra, and mycobacterial culture, fungal...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Michael J Maze Gissela Nyakunga Philoteus A Sakasaka Kajiru G Kilonzo Elisha Luhwago Manase Chelangwa John A Crump Riziki M Kisonga Deng B Madut Josephine Rogath Adnan Sadiq Rennae Thiessen Matthew P Rubach Source Type: research
Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region
Am J Trop Med Hyg. 2023 Aug 21:tpmd230039. doi: 10.4269/ajtmh.23-0039. Online ahead of print.ABSTRACTTuberculosis remains a challenge in both rural and urban areas. Although a majority of countries display a higher burden in urban areas compared with rural areas, Panama continues to report the highest mortality rate in Central America. Urban areas, such as Panama City, report a high tuberculosis burden, whereas Panama's western region, including the provinces of Chiriquí, Bocas del Toro (both semiurban) and Ngäbe-Bugle (rural), show a lower burden. We aimed to identify highly transmitted Mycobacterium tuberculosis strain...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Fermin Acosta Ricardo Salda ña Sara Miranda Daniela Candanedo Dilcia Sambrano Mitchelle Mor án Saily Bejarano Yeraldine De Arriba Angel Reigosa Elizabeth De Dixon Mar ía Atencio Ram ón Castillo Amador Goodridge Source Type: research
Etiologic Investigation of Patients Diagnosed with Bacteriologically Unconfirmed Tuberculosis in Tanzania
Am J Trop Med Hyg. 2023 Aug 21:tpmd230023. doi: 10.4269/ajtmh.23-0023. Online ahead of print.ABSTRACTGlobally, half of patients with pulmonary tuberculosis (PTB) are diagnosed clinically without bacteriologic confirmation. In clinically diagnosed PTB patients, we assessed both the proportion in whom PTB could be bacteriologically confirmed by reference standard diagnostic tests and the prevalence of diseases that mimic PTB. We recruited adult patients beginning treatment of bacteriologically unconfirmed PTB in Moshi, Tanzania, in 2019. We performed mycobacterial smear, Xpert MTB/RIF Ultra, and mycobacterial culture, fungal...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Michael J Maze Gissela Nyakunga Philoteus A Sakasaka Kajiru G Kilonzo Elisha Luhwago Manase Chelangwa John A Crump Riziki M Kisonga Deng B Madut Josephine Rogath Adnan Sadiq Rennae Thiessen Matthew P Rubach Source Type: research
Bacterial dissemination in < em > Mycobacterium tuberculosis < /em > by CD+ T-cells & amp; proinflammatory cytokines
CONCLUSIONS: Our findings imply that increased bacilli in the spleen at the 8th wk of infection may be caused by the overexpression of CD4+ T-cell lymphocyte subsets and cytokines that generated inflammation during the 4th wk of infection. This is a pilot study with a small sample size and less assertive inference. Larger studies would be helpful to validate the results of the present investigation.PMID:37602585 | DOI:10.4103/ijmr.ijmr_2143_21
Source: Indian J Med Res - August 21, 2023 Category: Research Authors: Kusuma Sai Davuluri Shoor Vir Singh D S Chauhan Source Type: research
Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region
Am J Trop Med Hyg. 2023 Aug 21:tpmd230039. doi: 10.4269/ajtmh.23-0039. Online ahead of print.ABSTRACTTuberculosis remains a challenge in both rural and urban areas. Although a majority of countries display a higher burden in urban areas compared with rural areas, Panama continues to report the highest mortality rate in Central America. Urban areas, such as Panama City, report a high tuberculosis burden, whereas Panama's western region, including the provinces of Chiriquí, Bocas del Toro (both semiurban) and Ngäbe-Bugle (rural), show a lower burden. We aimed to identify highly transmitted Mycobacterium tuberculosis strain...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Fermin Acosta Ricardo Salda ña Sara Miranda Daniela Candanedo Dilcia Sambrano Mitchelle Mor án Saily Bejarano Yeraldine De Arriba Angel Reigosa Elizabeth De Dixon Mar ía Atencio Ram ón Castillo Amador Goodridge Source Type: research
Etiologic Investigation of Patients Diagnosed with Bacteriologically Unconfirmed Tuberculosis in Tanzania
Am J Trop Med Hyg. 2023 Aug 21:tpmd230023. doi: 10.4269/ajtmh.23-0023. Online ahead of print.ABSTRACTGlobally, half of patients with pulmonary tuberculosis (PTB) are diagnosed clinically without bacteriologic confirmation. In clinically diagnosed PTB patients, we assessed both the proportion in whom PTB could be bacteriologically confirmed by reference standard diagnostic tests and the prevalence of diseases that mimic PTB. We recruited adult patients beginning treatment of bacteriologically unconfirmed PTB in Moshi, Tanzania, in 2019. We performed mycobacterial smear, Xpert MTB/RIF Ultra, and mycobacterial culture, fungal...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Michael J Maze Gissela Nyakunga Philoteus A Sakasaka Kajiru G Kilonzo Elisha Luhwago Manase Chelangwa John A Crump Riziki M Kisonga Deng B Madut Josephine Rogath Adnan Sadiq Rennae Thiessen Matthew P Rubach Source Type: research
Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region
Am J Trop Med Hyg. 2023 Aug 21:tpmd230039. doi: 10.4269/ajtmh.23-0039. Online ahead of print.ABSTRACTTuberculosis remains a challenge in both rural and urban areas. Although a majority of countries display a higher burden in urban areas compared with rural areas, Panama continues to report the highest mortality rate in Central America. Urban areas, such as Panama City, report a high tuberculosis burden, whereas Panama's western region, including the provinces of Chiriquí, Bocas del Toro (both semiurban) and Ngäbe-Bugle (rural), show a lower burden. We aimed to identify highly transmitted Mycobacterium tuberculosis strain...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Fermin Acosta Ricardo Salda ña Sara Miranda Daniela Candanedo Dilcia Sambrano Mitchelle Mor án Saily Bejarano Yeraldine De Arriba Angel Reigosa Elizabeth De Dixon Mar ía Atencio Ram ón Castillo Amador Goodridge Source Type: research
Etiologic Investigation of Patients Diagnosed with Bacteriologically Unconfirmed Tuberculosis in Tanzania
Am J Trop Med Hyg. 2023 Aug 21:tpmd230023. doi: 10.4269/ajtmh.23-0023. Online ahead of print.ABSTRACTGlobally, half of patients with pulmonary tuberculosis (PTB) are diagnosed clinically without bacteriologic confirmation. In clinically diagnosed PTB patients, we assessed both the proportion in whom PTB could be bacteriologically confirmed by reference standard diagnostic tests and the prevalence of diseases that mimic PTB. We recruited adult patients beginning treatment of bacteriologically unconfirmed PTB in Moshi, Tanzania, in 2019. We performed mycobacterial smear, Xpert MTB/RIF Ultra, and mycobacterial culture, fungal...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Michael J Maze Gissela Nyakunga Philoteus A Sakasaka Kajiru G Kilonzo Elisha Luhwago Manase Chelangwa John A Crump Riziki M Kisonga Deng B Madut Josephine Rogath Adnan Sadiq Rennae Thiessen Matthew P Rubach Source Type: research
Bacterial dissemination in < em > Mycobacterium tuberculosis < /em > by CD+ T-cells & amp; proinflammatory cytokines
CONCLUSIONS: Our findings imply that increased bacilli in the spleen at the 8th wk of infection may be caused by the overexpression of CD4+ T-cell lymphocyte subsets and cytokines that generated inflammation during the 4th wk of infection. This is a pilot study with a small sample size and less assertive inference. Larger studies would be helpful to validate the results of the present investigation.PMID:37602585 | DOI:10.4103/ijmr.ijmr_2143_21
Source: The Indian Journal of Medical Research - August 21, 2023 Category: Biomedical Science Authors: Kusuma Sai Davuluri Shoor Vir Singh D S Chauhan Source Type: research
Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region
Am J Trop Med Hyg. 2023 Aug 21:tpmd230039. doi: 10.4269/ajtmh.23-0039. Online ahead of print.ABSTRACTTuberculosis remains a challenge in both rural and urban areas. Although a majority of countries display a higher burden in urban areas compared with rural areas, Panama continues to report the highest mortality rate in Central America. Urban areas, such as Panama City, report a high tuberculosis burden, whereas Panama's western region, including the provinces of Chiriquí, Bocas del Toro (both semiurban) and Ngäbe-Bugle (rural), show a lower burden. We aimed to identify highly transmitted Mycobacterium tuberculosis strain...
Source: Rural Remote Health - August 21, 2023 Category: Rural Health Authors: Fermin Acosta Ricardo Salda ña Sara Miranda Daniela Candanedo Dilcia Sambrano Mitchelle Mor án Saily Bejarano Yeraldine De Arriba Angel Reigosa Elizabeth De Dixon Mar ía Atencio Ram ón Castillo Amador Goodridge Source Type: research
Etiologic Investigation of Patients Diagnosed with Bacteriologically Unconfirmed Tuberculosis in Tanzania
Am J Trop Med Hyg. 2023 Aug 21:tpmd230023. doi: 10.4269/ajtmh.23-0023. Online ahead of print.ABSTRACTGlobally, half of patients with pulmonary tuberculosis (PTB) are diagnosed clinically without bacteriologic confirmation. In clinically diagnosed PTB patients, we assessed both the proportion in whom PTB could be bacteriologically confirmed by reference standard diagnostic tests and the prevalence of diseases that mimic PTB. We recruited adult patients beginning treatment of bacteriologically unconfirmed PTB in Moshi, Tanzania, in 2019. We performed mycobacterial smear, Xpert MTB/RIF Ultra, and mycobacterial culture, fungal...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Michael J Maze Gissela Nyakunga Philoteus A Sakasaka Kajiru G Kilonzo Elisha Luhwago Manase Chelangwa John A Crump Riziki M Kisonga Deng B Madut Josephine Rogath Adnan Sadiq Rennae Thiessen Matthew P Rubach Source Type: research
