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Infectious Disease: Tuberculosis
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Total 20175 results found since Jan 2013.
"Uncommon location for a common disease, simulating cervical cancer: A rare case report"
CONCLUSION: Hence, cervical tuberculosis should be kept in the differential diagnosis of cervical cancer especially in an infertile woman from a developing country.PMID:37608615 | DOI:10.2174/1871526523666230822155148
Source: Infectious Disorders Drug Targets - August 23, 2023 Category: Infectious Diseases Authors: Naina Kumar Kanikaram Poojitha Kalyani Abhimanyu Sharma Sumitra Sivakoti Mishu Mangla Source Type: research
Broadening access to tenofovir alafenamide for the treatment and prevention of HIV-1 infection
Expert Rev Clin Pharmacol. 2023 Aug 23. doi: 10.1080/17512433.2023.2251387. Online ahead of print.ABSTRACTINTRODUCTION: Tenofovir alafenamide (TAF), a prodrug of tenofovir achieves higher intracellular concentrations of tenofovir-diphosphate and 90% lower plasma concentrations of tenofovir compared to tenofovir disoproxil fumarate (TDF). TAF is associated with improved renal and bone safety outcomes.AREAS COVERED: We review the efficacy and safety of TAF-containing regimens in adults and pediatrics. We highlight safety data during pregnancy, drug interactions during co-administration with tuberculosis treatment, and critic...
Source: Pharmacological Reviews - August 23, 2023 Category: Drugs & Pharmacology Authors: Emmanuella Chinonso Osuala Anushka Naidoo Kelly E Dooley Kogieleum Naidoo Rubeshan Perumal Source Type: research
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and < em > in vivo < /em > efficacy
Antimicrob Agents Chemother. 2023 Aug 23:e0047423. doi: 10.1128/aac.00474-23. Online ahead of print.ABSTRACTNitro-containing compounds have emerged as important agents in the control of tuberculosis (TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) growth inhibitors, 10 nitro-containing compounds were prioritized for characterization and mechanism of action studies. HC2209, HC2210, and HC2211 are nitrofuran-based prodrugs that need the cofactor F420 machinery for activation. Unlike pretomanid which depends only on deazaflavin-dependent nitroreductase (Ddn), these nitrofurans depend on Ddn ...
Source: Antimicrobial Agents and Chemotherapy - August 23, 2023 Category: Microbiology Authors: Ifeanyichukwu E Eke John T Williams Elizabeth R Haiderer Veronica J Albrecht Heather M Murdoch Bassel J Abdalla Robert B Abramovitch Source Type: research
Broadening access to tenofovir alafenamide for the treatment and prevention of HIV-1 infection
Expert Rev Clin Pharmacol. 2023 Aug 23. doi: 10.1080/17512433.2023.2251387. Online ahead of print.ABSTRACTINTRODUCTION: Tenofovir alafenamide (TAF), a prodrug of tenofovir achieves higher intracellular concentrations of tenofovir-diphosphate and 90% lower plasma concentrations of tenofovir compared to tenofovir disoproxil fumarate (TDF). TAF is associated with improved renal and bone safety outcomes.AREAS COVERED: We review the efficacy and safety of TAF-containing regimens in adults and pediatrics. We highlight safety data during pregnancy, drug interactions during co-administration with tuberculosis treatment, and critic...
Source: Expert Review of Clinical Pharmacology - August 23, 2023 Category: Drugs & Pharmacology Authors: Emmanuella Chinonso Osuala Anushka Naidoo Kelly E Dooley Kogieleum Naidoo Rubeshan Perumal Source Type: research
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and < em > in vivo < /em > efficacy
Antimicrob Agents Chemother. 2023 Aug 23:e0047423. doi: 10.1128/aac.00474-23. Online ahead of print.ABSTRACTNitro-containing compounds have emerged as important agents in the control of tuberculosis (TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) growth inhibitors, 10 nitro-containing compounds were prioritized for characterization and mechanism of action studies. HC2209, HC2210, and HC2211 are nitrofuran-based prodrugs that need the cofactor F420 machinery for activation. Unlike pretomanid which depends only on deazaflavin-dependent nitroreductase (Ddn), these nitrofurans depend on Ddn ...
Source: Antimicrobial Agents and Chemotherapy - August 23, 2023 Category: Microbiology Authors: Ifeanyichukwu E Eke John T Williams Elizabeth R Haiderer Veronica J Albrecht Heather M Murdoch Bassel J Abdalla Robert B Abramovitch Source Type: research
Broadening access to tenofovir alafenamide for the treatment and prevention of HIV-1 infection
Expert Rev Clin Pharmacol. 2023 Aug 23. doi: 10.1080/17512433.2023.2251387. Online ahead of print.ABSTRACTINTRODUCTION: Tenofovir alafenamide (TAF), a prodrug of tenofovir achieves higher intracellular concentrations of tenofovir-diphosphate and 90% lower plasma concentrations of tenofovir compared to tenofovir disoproxil fumarate (TDF). TAF is associated with improved renal and bone safety outcomes.AREAS COVERED: We review the efficacy and safety of TAF-containing regimens in adults and pediatrics. We highlight safety data during pregnancy, drug interactions during co-administration with tuberculosis treatment, and critic...
Source: Expert Review of Clinical Pharmacology - August 23, 2023 Category: Drugs & Pharmacology Authors: Emmanuella Chinonso Osuala Anushka Naidoo Kelly E Dooley Kogieleum Naidoo Rubeshan Perumal Source Type: research
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and < em > in vivo < /em > efficacy
Antimicrob Agents Chemother. 2023 Aug 23:e0047423. doi: 10.1128/aac.00474-23. Online ahead of print.ABSTRACTNitro-containing compounds have emerged as important agents in the control of tuberculosis (TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) growth inhibitors, 10 nitro-containing compounds were prioritized for characterization and mechanism of action studies. HC2209, HC2210, and HC2211 are nitrofuran-based prodrugs that need the cofactor F420 machinery for activation. Unlike pretomanid which depends only on deazaflavin-dependent nitroreductase (Ddn), these nitrofurans depend on Ddn ...
Source: Antimicrobial Agents and Chemotherapy - August 23, 2023 Category: Microbiology Authors: Ifeanyichukwu E Eke John T Williams Elizabeth R Haiderer Veronica J Albrecht Heather M Murdoch Bassel J Abdalla Robert B Abramovitch Source Type: research
"Uncommon location for a common disease, simulating cervical cancer: A rare case report"
CONCLUSION: Hence, cervical tuberculosis should be kept in the differential diagnosis of cervical cancer especially in an infertile woman from a developing country.PMID:37608615 | DOI:10.2174/1871526523666230822155148
Source: Infectious Disorders Drug Targets - August 23, 2023 Category: Infectious Diseases Authors: Naina Kumar Kanikaram Poojitha Kalyani Abhimanyu Sharma Sumitra Sivakoti Mishu Mangla Source Type: research
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and < em > in vivo < /em > efficacy
Antimicrob Agents Chemother. 2023 Aug 23:e0047423. doi: 10.1128/aac.00474-23. Online ahead of print.ABSTRACTNitro-containing compounds have emerged as important agents in the control of tuberculosis (TB). From a whole-cell high-throughput screen for Mycobacterium tuberculosis (Mtb) growth inhibitors, 10 nitro-containing compounds were prioritized for characterization and mechanism of action studies. HC2209, HC2210, and HC2211 are nitrofuran-based prodrugs that need the cofactor F420 machinery for activation. Unlike pretomanid which depends only on deazaflavin-dependent nitroreductase (Ddn), these nitrofurans depend on Ddn ...
Source: Antimicrobial Agents and Chemotherapy - August 23, 2023 Category: Microbiology Authors: Ifeanyichukwu E Eke John T Williams Elizabeth R Haiderer Veronica J Albrecht Heather M Murdoch Bassel J Abdalla Robert B Abramovitch Source Type: research
