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Infectious Disease: Hepatitis B
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Total 12607 results found since Jan 2013.
Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
World J Gastroenterol. 2023 Aug 21;29(31):4706-4735. doi: 10.3748/wjg.v29.i31.4706.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy with a high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection is one of the most important risk factors for its occurrence and development. Early detection of HBV-associated HCC (HBV-HCC) can improve clinical decision-making and patient outcomes. Biomarkers are extremely helpful, not only for early diagnosis, but also for the development of therapeutics. MicroRNAs (miRNAs), a subset of non-coding RNAs approximately 22 nucleotides in length, have increasingly attrac...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Ming-He Zhang Yu-Feng Yuan Li-Juan Liu Yu-Xin Wei Wan-Yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxvn Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxun Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research
Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking
Medicine (Baltimore). 2023 Sep 1;102(35):e34945. doi: 10.1097/MD.0000000000034945.ABSTRACTAccording to current research, the primary active ingredients of Radix Astragali (RA), such as saponins, flavonoids, and polysaccharides, play an important role in anti-inflammatory effects. However, the exact molecular mechanism underlying the action was not elucidated to date. Our research attempted to determine the active components in RA and to investigate the interaction between the active components and targets involved in the anti-inflammation activity by network pharmacology and molecular docking. The active components and tar...
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Jianwei Ren Yuetian Ding Shangze Li Ming Lei Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Current Cancer Drug Targets - September 1, 2023 Category: Cancer & Oncology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Seroprevalence of Hepatitis C Virus Infection in North Korean Defectors Residing in Korea
CONCLUSION: This is the first prospective study to investigate the prevalence rate of HCV infection among North Korean defectors residing in South Korea. As North Korean defectors are a vulnerable group concerning HCV infection, they may benefit from HCV screening policies and educational interventions for HCV infection.PMID:37644684 | DOI:10.3346/jkms.2023.38.e270
Source: J Korean Med Sci - August 30, 2023 Category: General Medicine Authors: Young Mi Hong Ki Tae Yoon Young Joo Park Hyun Young Woo Jeong Heo Source Type: research
Arbidol: The current demand, strategies, and antiviral mechanisms
CONCLUSION: ARB is a broad-spectrum antiviral drug that inhibits several viruses in vivo and in vitro, with high safety profile and low resistance; the antiviral mechanisms of ARB deserve to be further explored and more high-quality clinical studies are required to establish the efficacy and safety of ARB.PMID:37647451 | DOI:10.1002/iid3.984
Source: Herpes - August 30, 2023 Category: Infectious Diseases Authors: Yue Kang Yin Shi Silu Xu Source Type: research
Survey of blood collection and transfusion practices among institutions in Africa
This study highlights significant variability and restrictions in blood product availability, pre-transfusion testing, and blood donor infectious disease testing across Africa. Further studies are needed to ascertain barriers to improving blood donor availability, blood product safety, and infectious disease testing.PMID:37646070 | DOI:10.1111/trf.17501
Source: Transfusion - August 30, 2023 Category: Hematology Authors: Jeremy W Jacobs Laura D Stephens Danny A Milner Evan M Bloch Ruchika Goel Aaron A R Tobian Aaron Lunda Shibemba Quentin Eichbaum Vanderbilt Pathology Program in Global Health (VPPIGH) Source Type: research
