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Infectious Disease: Hepatitis B
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Total 12607 results found since Jan 2013.
Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
World J Gastroenterol. 2023 Aug 21;29(31):4706-4735. doi: 10.3748/wjg.v29.i31.4706.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy with a high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection is one of the most important risk factors for its occurrence and development. Early detection of HBV-associated HCC (HBV-HCC) can improve clinical decision-making and patient outcomes. Biomarkers are extremely helpful, not only for early diagnosis, but also for the development of therapeutics. MicroRNAs (miRNAs), a subset of non-coding RNAs approximately 22 nucleotides in length, have increasingly attrac...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Ming-He Zhang Yu-Feng Yuan Li-Juan Liu Yu-Xin Wei Wan-Yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Source Type: research
Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study
Nat Cancer. 2023 Sep 4. doi: 10.1038/s43018-023-00618-8. Online ahead of print.ABSTRACTCurrent guidelines recommend hepatocellular carcinoma (HCC) surveillance for at-risk individuals, including individuals with hepatitis B virus infection. However, the performance and survival benefits of annual screening have not been evaluated through multicenter prospective studies in a Chinese population. Between 2017 and 2021, we included 14,426 participants with hepatitis B surface antigen seropositivity in an annual HCC screening study in China using a multicenter prospective design with ultrasonography and serum alpha-fetoprotein....
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Hongmei Zeng Maomao Cao Changfa Xia Dongmei Wang Kun Chen Zheng Zhu Ruiying Fu Shaokai Zhang Jinyi Zhou Huadong Wang Xianyun Qi Shuguang Dai Yong Chen Zhong Sun Hao Ding Qingwen Li Hui Zhao Xuehong Zhang Jakub Morze John S Ji Feng Sun Xueqin Yu Wanqing Ch Source Type: research
Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
World J Gastroenterol. 2023 Aug 21;29(31):4706-4735. doi: 10.3748/wjg.v29.i31.4706.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy with a high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection is one of the most important risk factors for its occurrence and development. Early detection of HBV-associated HCC (HBV-HCC) can improve clinical decision-making and patient outcomes. Biomarkers are extremely helpful, not only for early diagnosis, but also for the development of therapeutics. MicroRNAs (miRNAs), a subset of non-coding RNAs approximately 22 nucleotides in length, have increasingly attrac...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Ming-He Zhang Yu-Feng Yuan Li-Juan Liu Yu-Xin Wei Wan-Yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Source Type: research
Pharmacophore-Based Virtual Screening and Structural Modification of Novel Benzamide Derivatives as HBV Capsid Assembly Modulators
Biol Pharm Bull. 2023;46(9):1277-1288. doi: 10.1248/bpb.b23-00242.ABSTRACTHepatitis B virus (HBV) infection is the most common cause of death from liver disease worldwide. The use of capsid assembly modulators is considered a prominent strategy for the development of novel anti-HBV therapies. We performed a pharmacophore-based virtual screening strategy, and a benzamide scaffold hit, WAI-5, was chosen for further structural optimization. A series of novel HBV capsid assembly modulators (CAMs) were found. Compared with the lead hit, the representative compounds 11g and 11n exhibited a 10-fold increase in anti-HBV activity w...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yiyang Qin Shengdan Wang Yunwen Wang Yuan Wang Xuefen Tao Hui Zhao Hao Wang Shuang Yu Rong Sheng Source Type: research
